STRINGSTRING
sefC sefC staA staA fimA fimA sifA sifA STY1271 STY1271 STY1450 STY1450 fliA fliA fliC fliC prgH prgH sipA sipA invA invA rpoS rpoS tolC tolC stgA stgA mgtC mgtC mgtB mgtB pilS pilS tviB tviB tviA tviA sefB sefB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sefCSimilar to Salmonella enteritidis outer membrane usher protein SefC precursor SW:SEFC_SALEN (P33388) (814 aa) fasta scores: E(): 0, 96.7% id in 838 aa, and to Salmonella typhimurium outer membrane usher protein FimD precursor fimD SW:FIMD_SALTY (P37924) (870 aa) fasta scores: E(): 0, 31.0% id in 836 aa. Identity with SefC is distrupted with Glycine-Valine repeat between codons 301 and 330. TTGGTG repeated 14 times. Possible effect on function. CDS DNA has a low GC content,35.71%. (838 aa)
staAPutative fimbrial protein; Similar to Klebsiella pneumoniae fimbrial subunit type 3 precursor mrkA SW:FM3_KLEPN (P12267) (202 aa) fasta scores: E(): 8.9e-05, 31.8% id in 214 aa, and to Salmonella typhimurium major fimbrial antigen subunit pefA TR:P72422 (EMBL:Y07657) (174 aa) fasta scores: E(): 0.00082, 30.8% id in 159 aa; Orthologue of E. coli yadN (YADN_ECOLI); Fasta hit to YADN_ECOLI (194 aa), 38% identity in 197 aa overlap. (194 aa)
fimAType-1 fimbrial protein, a chain precursor; Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs; Belongs to the fimbrial protein family. (184 aa)
sifAPutative virulence determinant; Similar to Salmonella typhimurium SifA protein sifA SW:SIFA_SALTY (Q56061) (336 aa) fasta scores: E(): 0, 93.5% id in 336 aa. (336 aa)
STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1450Putative phosphotransferase enzyme; Fasta hit to PTKC_ECOLI (451 aa), 42% identity in 431 aa overlap; Orthologue of E. coli yjhN (SGCC_ECOLI); Fasta hit to SGCC_ECOLI (437 aa), 95% identity in 437 aa overlap. (437 aa)
fliARNA polymerase sigma transcription factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (506 aa)
prgHPathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. (392 aa)
sipAPathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family. (685 aa)
invAPossible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (685 aa)
rpoSRNA polymerase sigma subunit RpoS (sigma-38); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
tolCSimilar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap. (491 aa)
stgAProbable fimbrial subunit protein; Similar to several including: Klebsiella pneumoniae Fimbrial subunit type 1 precursor Fim SW:FM12_KLEPN (P12903) (182 aa) fasta scores: E(): 8e-10, 38.2% id in 191 aa and Serratia marcescens type-1 fimbrial protein subunit precursor fimA SW:FM1A_SERMA (P22595) (180 aa) fasta scores: E(): 5.3e-09, 39.2% id in 194 aa; Fasta hit to SFMF_ECOLI (171 aa), 32% identity in 173 aa overlap; Fasta hit to FM1A_ECOLI (182 aa), 37% identity in 191 aa overlap; Fasta hit to FIMF_ECOLI (176 aa), 31% identity in 177 aa overlap; Paralogue of E. coli SFMA_ECOLI; Fasta hi [...] (191 aa)
mgtCConserved hyopthetical protein; Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity). Belongs to the MgtC/SapB family. (231 aa)
mgtBMagnesium transport ATPase, P-type 2; Similar to Salmonella typhimurium Magnesium transport ATPase MgtB SW:ATMB_SALTY (P22036) (908 aa) fasta scores: E(): 0, 99.2% id in 908 aa. Contains multiple possible membrane spanning hydrophobic domains. Note located within Salmonella pathogenicity island 3; Paralogue of E. coli mgtA (ATMA_ECOLI); Fasta hit to ATMA_ECOLI (898 aa), 53% identity in 877 aa overlap. (908 aa)
pilSPrepilin; Previously sequenced Salmonella typhi PilS protein TR:Q9ZIU9 (EMBL:AF000001) (206 aa) fasta scores: E(): 0, 100.0% id in 206 aa. Also similar to Escherichia coli plasmid IncI1 R64 type IV prepilin pilS TR:O88170 (EMBL:AB007463) (204 aa) fasta scores: E(): 1.6e-31, 49.2% id in 193 aa. (211 aa)
tviBSimilar to Salmonella typhi Vi polysaccharide biosynthesis protein VipA or TviB SW:VIPA_SALTI (Q04972) (425 aa) fasta scores: E(): 0, 99.8% id in 425 aa, and to Pseudomonas aeruginosa WbpO TR:Q9RHD7 (EMBL:AF035937) (422 aa) fasta scores: E(): 0, 66.8% id in 422 aa; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (425 aa)
tviASimilar to Salmonella typhi Vi polysaccharide biosynthesis protein TviA SW:TVIA_SALTI (Q04971) (179 aa) fasta scores: E(): 0, 100.0% id in 179 aa and to Salmonella paratyphi C VipR protein TR:BAA24231 (EMBL:AB006131) (179 aa) fasta scores: E(): 0, 100.0% id in 179 aa. (179 aa)
sefBSimilar to Salmonella enteritidis chaperone protein SefB precursor SW:SEFB_SALEN (P33387) (246 aa) fasta scores: E(): 0, 99.2% id in 246 aa, and to Yersinia pestis, and Yersinia pseudotuberculosis chaperone protein PsaB precursor SW:PSAB_YERPE (P31523) (273 aa) fasta scores: E(): 4e-25, 33.5% id in 257 aa, and to Escherichia coli chaperone protein AggD precursor SW:AGGD_ECOLI (P46004) (252 aa) fasta scores: E(): 2.1e-23, 33.5% id in 209 aa. CDS DNA has a low GC content, 28.81%. (250 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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