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STY3076 STY3076 STY3639 STY3639 STY3749 STY3749 STY3760 STY3760 soxR soxR STY1339 STY1339 btuE btuE STY1793 STY1793 STY2094 STY2094 STY2651 STY2651 STY2652 STY2652 STY2653 STY2653 STY2666 STY2666 STY2678 STY2678 STY2679 STY2679 STY2842 STY2842 cysC cysC soxS soxS STY4205 STY4205 STY0905 STY0905 STY0655 STY0655 STY0177 STY0177 cysD cysD STY3075 STY3075
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STY3076Sulfite reductase (NADPH) flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa)
STY3639Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (109 aa)
STY3749Hydrogen peroxide-inducible regulon activator; Fasta hit to YNFL_ECOLI (297 aa), 32% identity in 248 aa overlap; Fasta hit to CYNR_ECOLI (299 aa), 31% identity in 273 aa overlap; Orthologue of E. coli oxyR (OXYR_ECOLI); Fasta hit to OXYR_ECOLI (305 aa), 96% identity in 305 aa overlap; Belongs to the LysR transcriptional regulatory family. (305 aa)
STY3760Catalase (hydroperoxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)
soxRSoxR protein; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity). (152 aa)
STY1339Aconitate hydratase 1 (citrate hydro-lyase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
btuEPutative glutathione peroxidase/vitamin B12 transport periplasmic protein BtuE; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. (183 aa)
STY1793Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa)
STY2094Glucose 6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
STY2651Putative membrane protein; Orthologue of E. coli yfeA (P76529); Fasta hit to P76529 (768 aa), 69% identity in 722 aa overlap. N-terminal half contains hydrophobic, probable membrane-spanning regions. (729 aa)
STY2652Conserved hypothetical protein; Fasta hit to YFED_ECOLI (130 aa), 35% identity in 126 aa overlap; Orthologue of E. coli yfeC (YFEC_ECOLI); Fasta hit to YFEC_ECOLI (114 aa), 78% identity in 115 aa overlap. (120 aa)
STY2653Conserved hypothetical protein; Fasta hit to YFEC_ECOLI (114 aa), 40% identity in 124 aa overlap; Orthologue of E. coli yfeD (YFED_ECOLI); Fasta hit to YFED_ECOLI (130 aa), 70% identity in 129 aa overlap. (130 aa)
STY2666Cysteine synthase A; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product (By similarity). (323 aa)
STY2678Sulphate transport ATP-binding protein CysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (364 aa)
STY2679Sulphate transport system permease protein CysW; Fasta hit to CYST_ECOLI (277 aa), 37% identity in 259 aa overlap; Orthologue of E. coli cysW (CYSW_ECOLI); Fasta hit to CYSW_ECOLI (291 aa), 97% identity in 291 aa overlap. (291 aa)
STY2842Thioredoxin 2; Orthologue of E. coli yfiG (THI2_ECOLI); Fasta hit to THI2_ECOLI (139 aa), 94% identity in 139 aa overlap; Belongs to the thioredoxin family. (139 aa)
cysCAdenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
soxSRegulatory protein SoxS; Orthologue of E. coli soxS (SOXS_ECOLI); Fasta hit to SOXS_ECOLI (106 aa), 94% identity in 106 aa overlap. (107 aa)
STY4205Similar to Escherichia coli glutathione reductase gor SW:GSHR_ECOLI (P06715) (450 aa) fasta scores: E(): 0, 94.7% id in 450 aa, and to Haemophilus influenzae glutathione reductase HI0161 SW:GSHR_HAEIN (P43783) (456 aa) fasta scores: E(): 0, 74.8% id in 457 aa. (450 aa)
STY0905Glutaredoxin 1; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity); Belongs to the glutaredoxin family. (87 aa)
STY0655Alkyl hydroperoxide reductase F52A protein (subunit F); Orthologue of E. coli ahpF (AHPF_ECOLI); Fasta hit to AHPF_ECOLI (521 aa), 95% identity in 521 aa overlap. (521 aa)
STY0177Dihydrolipoamide dehydrogenase; Orthologue of E. coli lpdA (DLDH_ECOLI); Fasta hit to DLDH_ECOLI (473 aa), 98% identity in 473 aa overlap. (475 aa)
cysDATP sulfurylase (ATP:sulfate adenyltransferase); Orthologue of E. coli cysD (CYSD_ECOLI); Fasta hit to CYSD_ECOLI (302 aa), 97% identity in 302 aa overlap. (302 aa)
STY3075Sulfite reductase (NADPH) hemoprotein alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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