STRINGSTRING
STY1963 STY1963 STY2342 STY2342 mntH mntH STY3077 STY3077 STY3080 STY3080 STY3107 STY3107 STY3210 STY3210 STY3211 STY3211 STY3638 STY3638 STY3709 STY3709 mgtB mgtB STY0225 STY0225 ybaX ybaX STY0758 STY0758 STY0876 STY0876 STY1226 STY1226 mgtA mgtA STY4416 STY4416 STY1270 STY1270 STY1271 STY1271 STY1691 STY1691 STY1744 STY1744 STY2096 STY2096
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY1963Putative membrane protein; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. (206 aa)
STY2342Putative transporter protein; Fasta hit to YIEO_ECOLI (475 aa), 46% identity in 459 aa overlap; Orthologue of E. coli YEGB_ECOLI; Fasta hit to YEGB_ECOLI (471 aa), 86% identity in 469 aa overlap; Similar to many putative major facilitator family transporter proteins. Contains hydrophobic, probable membrane-spanning regions. (470 aa)
mntHManganese transport protein MntH; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (413 aa)
STY3077Highly similar to Escherichia coli putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM SW:PTPS_ECOLI (Q46903) (121 aa) fasta scores: E(): 0, 94.2% id in 120 aa; Orthologue of E. coli PTPS_ECOLI; Fasta hit to PTPS_ECOLI (121 aa), 94% identity in 120 aa overlap. (120 aa)
STY3080Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)
STY3107Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa)
STY3210Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
STY3211Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
STY3638Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
STY3709Phosphoribosylaminoimidazolecarboxamide formyltransferase; Orthologue of E. coli purH (PUR9_ECOLI); Fasta hit to PUR9_ECOLI (529 aa), 94% identity in 529 aa overlap. (529 aa)
mgtBMagnesium transport ATPase, P-type 2; Similar to Salmonella typhimurium Magnesium transport ATPase MgtB SW:ATMB_SALTY (P22036) (908 aa) fasta scores: E(): 0, 99.2% id in 908 aa. Contains multiple possible membrane spanning hydrophobic domains. Note located within Salmonella pathogenicity island 3; Paralogue of E. coli mgtA (ATMA_ECOLI); Fasta hit to ATMA_ECOLI (898 aa), 53% identity in 877 aa overlap. (908 aa)
STY0225Putative membrane protein; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa)
ybaXConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
STY0758Hypothetical protein; No database matches. (246 aa)
STY0876Transcriptional regulator (iron dependant repressor family); In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family. (157 aa)
STY1226Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1067 aa)
mgtAMg(2+) transport ATPase, P-type; Similar to Salmonella typhimurium Mg2+ transport ATPase MgtA mgtA SW:ATMA_SALTY (P36640) (902 aa) fasta scores: E(): 0, 99.2% id in 902 aa, and to Escherichia coli mg mgta or mgt or corB SW:ATMA_ECOLI (P39168) (898 aa) fasta scores: E(): 0, 90.4% id in 896 aa. (902 aa)
STY4416Similar to Escherichia coli lysine-sensitive aspartokinase III LysC SW:AK3_ECOLI (P08660) (449 aa) fasta scores: E(): 0, 93.3% id in 449 aa; Belongs to the aspartokinase family. (449 aa)
STY1270Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] (487 aa)
STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1691Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (193 aa)
STY1744Pyruvate kinase; Fasta hit to KPY2_ECOLI (479 aa), 38% identity in 480 aa overlap; Orthologue of E. coli pykF (KPY1_ECOLI); Fasta hit to KPY1_ECOLI (470 aa), 96% identity in 470 aa overlap. (470 aa)
STY2096Pyruvate kinase A; Fasta hit to KPY1_ECOLI (470 aa), 37% identity in 480 aa overlap; Orthologue of E. coli pykA (KPY2_ECOLI); Fasta hit to KPY2_ECOLI (479 aa), 98% identity in 479 aa overlap; Belongs to the pyruvate kinase family. (480 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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