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STY2996 STY2996 prgH prgH prgK prgK sprA sprA fliC fliC STY1352 STY1352 STY1236 STY1236 STY1233 STY1233 STY1223 STY1223 STY1222 STY1222 STY0153 STY0153 STY0121 STY0121 spaO spaO sipC sipC rpoS rpoS invA invA spaI spaI sipD sipD sipA sipA iagA iagA groEL groEL STY4416 STY4416 STY3638 STY3638 STY3560 STY3560 STY3390 STY3390
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STY2996AraC-family transcriptional regulator; Similar to several from Salmonella typhimurium including: TR:Q9X5C3 (EMBL:AF124398) HilD transcriptional regulator (309 aa) fasta scores: E(): 0, 99.4% id in 309 aa and SW:YGBG_SALTY (P41782) hypothetical 17.2 kDa protein found upstream of prgH fasta scores: E(): 0, 87.9% id in 132 aa. (309 aa)
prgHPathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. (392 aa)
prgKPathogenicity 1 island effector protein; Similar to several proteins essential for protein secretion by a type III system: Salmonella typhimurium protein precursor PrgK required for invasion of epithelial cells SW:PRGK_SALTY (P41786) (252 aa) fasta scores: E(): 0, 99.6% id in 252 aa and Shigella flexneri lipoprotein MxiJ secretion protein SW:MXIJ_SHIFL (Q06081) (241 aa) fasta scores: E(): 0, 46.1% id in 243 aa. Contains a possible N-terminal signal sequence. (252 aa)
sprAPossible AraC-family transcriptional regulator; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). (295 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (506 aa)
STY1352Enoyl-[acyl-carrier-protein] reductase (NADH); Orthologue of E. coli fabI (FABI_ECOLI); Fasta hit to FABI_ECOLI (261 aa), 98% identity in 261 aa overlap. (262 aa)
STY12363-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
STY1233Malonyl CoA-acyl carrier protein transacylase; Orthologue of E. coli fabD (FABD_ECOLI); Fasta hit to FABD_ECOLI (308 aa), 94% identity in 306 aa overlap. (309 aa)
STY1223Flagellar hook-associated protein 3; Orthologue of E. coli flgL (FLGL_ECOLI); Fasta hit to FLGL_ECOLI (317 aa), 82% identity in 317 aa overlap. (317 aa)
STY1222Flagellar hook-associated protein 1; Orthologue of E. coli flgK (FLGK_ECOLI); Fasta hit to FLGK_ECOLI (546 aa), 80% identity in 554 aa overlap. (553 aa)
STY0153Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
STY0121Arabinose operon regulatory protein; Orthologue of E. coli araC (ARAC_ECOLI); Fasta hit to ARAC_ECOLI (292 aa), 92% identity in 281 aa overlap. (281 aa)
spaOSurface presentation of antigens protein (associated with type III secretion and virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (303 aa)
sipCPathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity). (409 aa)
rpoSRNA polymerase sigma subunit RpoS (sigma-38); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
invAPossible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (685 aa)
spaISecretory apparatus ATP synthase (associated with virulence); Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells (By similarity). (431 aa)
sipDPathogenicity island 1 effector protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC (By similarity). (340 aa)
sipAPathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family. (685 aa)
iagAInvasion protein regulator; The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of invF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon (By similarity). (553 aa)
groELGroEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
STY4416Similar to Escherichia coli lysine-sensitive aspartokinase III LysC SW:AK3_ECOLI (P08660) (449 aa) fasta scores: E(): 0, 93.3% id in 449 aa; Belongs to the aspartokinase family. (449 aa)
STY3638Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
STY3560Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
STY3390RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (660 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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