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STY1179 STY1179 STY0139 STY0139 pagP pagP STY0814 STY0814 STY0815 STY0815 STY0816 STY0816 STY1271 STY1271 STY1355 STY1355 STY1356 STY1356 STY1542 STY1542 STY2133 STY2133 STY2134 STY2134 fliC fliC pqaB pqaB csrA csrA sprB sprB sprA sprA STY2996 STY2996 rpoS rpoS STY3390 STY3390
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY1179Putative regulatory protein; Orthologue of E. coli csgD (CSGD_ECOLI); Fasta hit to CSGD_ECOLI (216 aa), 92% identity in 208 aa overlap. (208 aa)
STY0139Conserved hypothetical protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (152 aa)
pagPAntimicrobial peptide resistance and lipid A acylation protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (190 aa)
STY0814Molybdate-binding periplasmic protein precursor; Orthologue of E. coli modA (MODA_ECOLI); Fasta hit to MODA_ECOLI (257 aa), 86% identity in 257 aa overlap. (257 aa)
STY0815Molybdenum transport system permease protein ModB; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa)
STY0816Molybdenum transport ATP-binding protein ModC; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1355Peptide transport system ATP-binding protein SapF; Fasta hit to YCFV_ECOLI (233 aa), 32% identity in 232 aa overlap; Fasta hit to YDDO_ECOLI (308 aa), 38% identity in 254 aa overlap; Fasta hit to YDDP_ECOLI (328 aa), 31% identity in 263 aa overlap; Fasta hit to YECC_ECOLI (250 aa), 30% identity in 257 aa overlap; Fasta hit to NIKE_ECOLI (268 aa), 33% identity in 234 aa overlap; Orthologue of E. coli sapF (SAPF_ECOLI); Fasta hit to SAPF_ECOLI (268 aa), 97% identity in 268 aa overlap. (268 aa)
STY1356Peptide transport system ATP-binding protein SapD; Fasta hit to OPPD_ECOLI (337 aa), 37% identity in 324 aa overlap; Fasta hit to YDDO_ECOLI (308 aa), 31% identity in 320 aa overlap; Fasta hit to YDDP_ECOLI (328 aa), 38% identity in 328 aa overlap; Fasta hit to OPPF_ECOLI (334 aa), 34% identity in 329 aa overlap; Fasta hit to DPPD_ECOLI (327 aa), 44% identity in 328 aa overlap; Orthologue of E. coli sapD (SAPD_ECOLI); Fasta hit to SAPD_ECOLI (330 aa), 96% identity in 330 aa overlap; Belongs to the ABC transporter superfamily. (330 aa)
STY1542Multiple antibiotic resistance protein MarB; Orthologue of E. coli marB (MARB_ECOLI); Fasta hit to MARB_ECOLI (72 aa), 47% identity in 71 aa overlap. (71 aa)
STY2133Flagellar transcriptional activator; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (194 aa)
STY2134Flagellar transcriptional activator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (116 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (506 aa)
pqaBMelittin resistance protein PqaB; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the glycosyltransferase 83 family. (548 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
sprBSimilar to Salmonella typhimurium transcriptional regulator SprB found on pathogenicity island 1 TR:Q9XC53 (EMBL:AF148689) (251 aa) fasta scores: E(): 0, 99.2% id in 251 aa. (251 aa)
sprAPossible AraC-family transcriptional regulator; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). (295 aa)
STY2996AraC-family transcriptional regulator; Similar to several from Salmonella typhimurium including: TR:Q9X5C3 (EMBL:AF124398) HilD transcriptional regulator (309 aa) fasta scores: E(): 0, 99.4% id in 309 aa and SW:YGBG_SALTY (P41782) hypothetical 17.2 kDa protein found upstream of prgH fasta scores: E(): 0, 87.9% id in 132 aa. (309 aa)
rpoSRNA polymerase sigma subunit RpoS (sigma-38); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
STY3390RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (660 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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