STRINGSTRING
STY0215 STY0215 STY3639 STY3639 STY3731 STY3731 STY3743 STY3743 steB steB STY2871 STY2871 stcC stcC STY1745 STY1745 STY1319 STY1319 STY1091 STY1091 STY1002 STY1002 STY0795 STY0795 fimD fimD safC safC lpxD lpxD yaeT yaeT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0215Penicillin-binding protein 1b; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (840 aa)
STY3639Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (109 aa)
STY3731DNA-directed RNA polymerase, beta'-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa)
STY3743Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (260 aa)
steBSimilar to Salmonella typhimurium outer membrane usher protein StfC TR:O87658 (EMBL:AF093503) (885 aa) fasta scores: E(): 0, 53.3% id in 891 aa. Contains a possible N-terminal signal sequence. (899 aa)
STY2871Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa)
stcCSimilar to many e.g. Escherichia coli outer membrane usher protein HtrE precursor htrE SW:HTRE_ECOLI (P33129) (865 aa) fasta scores: E(): 0, 33.0% id in 854 aa. Contains probable N-terminbal signal sequence; Fasta hit to YCBS_ECOLI (866 aa), 31% identity in 804 aa overlap; Fasta hit to FIMD_ECOLI (878 aa), 31% identity in 835 aa overlap; Fasta hit to HTRE_ECOLI (865 aa), 33% identity in 855 aa overlap; Fasta hit to SFMD_ECOLI (867 aa), 31% identity in 828 aa overlap; Orthologue of E. coli yehB (YEHB_ECOLI); Fasta hit to YEHB_ECOLI (826 aa), 75% identity in 829 aa overlap. (829 aa)
STY1745Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. (78 aa)
STY1319Putative outer membrane protein; Orthologue of E. coli yciD (OMPW_ECOLI); Fasta hit to OMPW_ECOLI (212 aa), 89% identity in 212 aa overlap. (212 aa)
STY1091Outer membrane protein A; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. (350 aa)
STY1002Outer membrane protein F precursor; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (363 aa)
STY0795Peptidoglycan-associated lipoprotein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (174 aa)
fimDSimilar to Salmonella typhimurium outer membrane usher protein FimD precursor fimD SW:FIMD_SALTY (P37924) (870 aa) fasta scores: E(): 0, 98.0% id in 870 aa, and to Escherichia coli outer membrane usher protein SfmD precursor sfmD SW:SFMD_ECOLI (P77468) (867 aa) fasta scores: E(): 0, 70.0% id in 853 aa, and to Escherichia coli outer membrane usher protein FimD precursor fimD SW:FIMD_ECOLI (P30130) (878 aa) fasta scores: E(): 0, 47.6% id in 867 aa; Fasta hit to YCBS_ECOLI (866 aa), 48% identity in 869 aa overlap; Fasta hit to YRAJ_ECOLI (838 aa), 38% identity in 848 aa overlap; Fasta hit [...] (870 aa)
safCSimilar to Escherichia coli aggregative adherence fimbria I usher protein AafC TR:Q9X4L5 (EMBL:AF114828) (856 aa) fasta scores: E(): 0, 49.9% id in 844 aa, and to Escherichia coli outer membrane usher protein AfaC precursor afaC SW:AFAC_ECOLI (P53517) (859 aa) fasta scores: E(): 0, 49.9% id in 849 aa; Fasta hit to YCBS_ECOLI (866 aa), 35% identity in 859 aa overlap; Fasta hit to YRAJ_ECOLI (838 aa), 36% identity in 843 aa overlap; Fasta hit to SFMD_ECOLI (867 aa), 35% identity in 846 aa overlap; Paralogue of E. coli fimD (FIMD_ECOLI); Fasta hit to FIMD_ECOLI (878 aa), 36% identity in 8 [...] (836 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
yaeTOuter membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (803 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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