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arcA arcA STY0432 STY0432 fimZ fimZ dpiA dpiA STY0743 STY0743 copR copR STY1271 STY1271 STY1285 STY1285 STY1297 STY1297 STY1647 STY1647 ssrA ssrA ssrB ssrB ttrR ttrR STY2125 STY2125 STY2126 STY2126 sirA sirA STY2344 STY2344 STY2388 STY2388 STY2472 STY2472 STY2495 STY2495 rcsC rcsC STY2545 STY2545 pgtA pgtA STY2809 STY2809 tctD tctD STY3096 STY3096 STY3354 STY3354 STY3507 STY3507 STY3711 STY3711 STY3812 STY3812 STY3876 STY3876 STY3951 STY3951 STY3992 STY3992 ompR ompR pmrA pmrA dcuR dcuR STY4935 STY4935 citB citB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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arcAGlobal response regulator; Similar to Escherichia coli aerobic respiration control protein ArcA SW:ARCA_ECOLI (P03026) (238 aa) fasta scores: E(): 0, 99.6% id in 238 aa, and to Haemophilus influenzae aerobic respiration control protein ArcA homolog ArcA or hi0884 SW:ARCA_HAEIN (P44918) (236 aa) fasta scores: E(): 0, 76.8% id in 237 aa. (238 aa)
STY0432Phosphate regulon transcriptional regulatory protein PhoB; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 231 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 41% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 34% identity in 220 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 36% identity in 223 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 39% identity in 232 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 227 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 35% identity in 230 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 229 aa overlap; Fasta [...] (229 aa)
fimZProbable transcriptional regulator (FimXZ protein); Similar to Salmonella typhimurium fimbriae z protein fimZ SW:FIMZ_SALTY (P26319) (210 aa) fasta scores: E(): 0, 99.0% id in 210 aa, and to Escherichia coli fimbriae z protein fimZ SW:FIMZ_ECOLI (P21502) (210 aa) fasta scores: E(): 0, 71.4% id in 210 aa, and to Bordetella pertussis, Bordetella bronchiseptica, and virulence factors putative positive transcription regulator BvgA bvgA SW:BVGA_BORPE (P16574) (209 aa) fasta scores: E(): 7.7e-28, 39.5% id in 205 aa, and to Escherichia coli putative positive transcription regulator EvgA evgA [...] (210 aa)
dpiATranscriptional regulator CriR; Similar to Escherichia coli, and Shigella flexneri transcriptional regulatory protein dpia dpia or citb or mpda or criR SW:DPIA_ECOLI (Q54149) (226 aa) fasta scores: E(): 0, 85.1% id in 208 aa, and to Klebsiella pneumoniae transcriptional regulatory protein CitB citB SW:CITB_KLEPN (P52688) (234 aa) fasta scores: E(): 0, 48.5% id in 204 aa; Orthologue of E. coli criR (DPIA_ECOLI); Fasta hit to DPIA_ECOLI (226 aa), 85% identity in 208 aa overlap. (226 aa)
STY0743KDP operon transcriptional regulatory protein; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 218 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 36% identity in 219 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 33% identity in 221 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 34% identity in 231 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 220 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 31% identity in 228 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 30% identity in 227 aa overlap; Fasta hit to PHOB [...] (225 aa)
copRResponse regulator; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 229 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 32% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 52% identity in 227 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 34% identity in 228 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 38% identity in 220 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 33% identity in 228 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 227 aa overlap; Fasta hit to PHOB_ECOLI (229 aa), 37% identi [...] (248 aa)
STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1285Nitrate/nitrite response regulator protein NarL; Fasta hit to UHPA_ECOLI (196 aa), 34% identity in 203 aa overlap; Fasta hit to NARP_ECOLI (215 aa), 44% identity in 214 aa overlap; Orthologue of E. coli narL (NARL_ECOLI); Fasta hit to NARL_ECOLI (216 aa), 95% identity in 216 aa overlap. (216 aa)
STY1297Putative regulatory protein; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. (337 aa)
STY1647Similar to Staphylococcus aureus response regulator YycF yycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 8.8e-28, 37.6% id in 234 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 213 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 229 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 32% identity in 232 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 33% identity in 235 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 233 aa overlap; Orthologue of E. coli rstA (RSTA_ECOLI); Fasta hit [...] (243 aa)
ssrAPutative two-component sensor kinase; Similar to Salmonella typhimurium SpiR TR:P74862 (EMBL:U51927) (823 aa) fasta scores: E(): 0, 98.1% id in 823 aa, and to Escherichia coli sensor protein TorS SW:TORS_ECOLI (P39453; P75887) (904 aa) fasta scores: E(): 1.3e-26, 27.8% id in 598 aa. (920 aa)
ssrBPutative two-component response regulator; Similar to Salmonella typhimurium SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 100.0% id in 193 aa, and to Streptococcus pneumoniae response regulator rr03 TR:Q9S1J7 (EMBL:AJ006393) (210 aa) fasta scores: E(): 1.4e-19, 34.5% id in 206 aa; Fasta hit to UHPA_ECOLI (196 aa), 33% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 32% identity in 198 aa overlap; Paralogue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 31% identity in 206 aa overlap. (212 aa)
ttrRPutative two-component response regulator; Similar to Salmonella typhimurium TtrR TR:Q9Z4T0 (EMBL:AJ224978) (206 aa) fasta scores: E(): 0, 100.0% id in 206 aa, and to Rhodobacter capsulatus c4-dicarboxylate transport transcriptional regulatory protein DctR SW:DCTR_RHOCA (P37740) (197 aa) fasta scores: E(): 2.1e-22, 39.1% id in 192 aa; Fasta hit to NARL_ECOLI (216 aa), 30% identity in 200 aa overlap; Paralogue of E. coli uhpA (UHPA_ECOLI); Fasta hit to UHPA_ECOLI (196 aa), 34% identity in 196 aa overlap. (206 aa)
STY2125Chemotaxis protein CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). (129 aa)
STY2126Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
sirAInvasion response-regulator; Similar to many response regulators e.g. Salmonella typhimurium quorum-sensor response-regulator controlling virulence functions SirA sirA TR:P96058 (EMBL:U67869) (218 aa) fasta scores: E(): 0, 99.5% id in 218 aa and Pseudomonas aeruginosa response regulator GacA gacA SW:GACA_PSEAE (Q51373; O06649) (214 aa) fasta scores: E(): 0, 59.8% id in 214 aa; Fasta hit to UHPA_ECOLI (196 aa), 35% identity in 188 aa overlap; Fasta hit to NARP_ECOLI (215 aa), 31% identity in 195 aa overlap; Orthologue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 97% i [...] (218 aa)
STY2344Putative two-component system response regulator; Fasta hit to TORR_ECOLI (230 aa), 37% identity in 231 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 35% identity in 223 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 33% identity in 228 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 35% identity in 222 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 37% identity in 241 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 32% identity in 233 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 225 aa overlap; Fasta hit to PHOB_ECOLI (229 aa), 40% identity in 224 aa overlap; Fasta hit to P [...] (240 aa)
STY2388Putative two-component system response regulator; Member of the two-component regulatory system BtsS/BtsR. BtsR regulates expression of btsT by binding to its promoter region. (239 aa)
STY2472Nitrate/nitrite response regulator protein NarP; Fasta hit to UHPA_ECOLI (196 aa), 37% identity in 195 aa overlap; Fasta hit to FIMZ_ECOLI (210 aa), 30% identity in 200 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 31% identity in 229 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 43% identity in 214 aa overlap; Fasta hit to UVRY_ECOLI (218 aa), 34% identity in 200 aa overlap; Orthologue of E. coli narP (NARP_ECOLI); Fasta hit to NARP_ECOLI (215 aa), 88% identity in 215 aa overlap. (215 aa)
STY2495Regulator of capsule synthesis B component; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
rcsCSensor protein RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (948 aa)
STY2545Putative receptor/regulator protein; Shows weak similarity to Bacillus subtilis chemotaxis CheV protein cheV SW:CHEV_BACSU (P37599) (303 aa) fasta scores: E(): 2.7e-17, 31.4% id in 299 aa and e.g. Vibrio parahaemolyticus chemotaxis CheV homolog cheV TR:Q9X9K3 (EMBL:U12817) (308 aa) fasta scores: E(): 5.7e-26, 32.6% id in 322 aa. (334 aa)
pgtASimilar to Salmonella typhimurium phosphoglycerate transport system transcriptional regulatory protein PgtA pgtA SW:PGTA_SALTY (P06184) (415 aa) fasta scores: E(): 0, 98.1% id in 415 aa. (415 aa)
STY2809Similar to many e.g. Escherichia coli transcriptional regulatory protein HydG hydG SW:HYDG_ECOLI (P14375) (441 aa) fasta scores: E(): 0, 44.6% id in 439 aa and Pseudomonas aeruginosa type 4 fimbriae expression regulatory protein PilR pilR SW:PILR_PSEAE (Q00934) (446 aa) fasta scores: E(): 0, 40.2% id in 443 aa; Fasta hit to HYDG_ECOLI (441 aa), 45% identity in 439 aa overlap; Fasta hit to NTRC_ECOLI (469 aa), 42% identity in 404 aa overlap; Fasta hit to YGAA_ECOLI (529 aa), 37% identity in 449 aa overlap; Fasta hit to ATOC_ECOLI (461 aa), 41% identity in 454 aa overlap; Orthologue of E [...] (445 aa)
tctDSimilar to Salmonella typhimurium transcriptional regulatory protein TctD SW:TCTD_SALTY (P22104) (224 aa) fasta scores: E(): 0, 99.1% id in 224 aa and Salmonella typhi AJB70 TctD protein TR:O68288 (EMBL:AF029846) (223 aa) fasta scores: E(): 0, 97.3% id in 224 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 226 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 33% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 38% identity in 226 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 220 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 36% identity in 228 aa overlap [...] (224 aa)
STY3096Sensor protein; Similar to Escherichia coli sensor protein BarA involved in adaptive response SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 90.0% id in 921 aa; Orthologue of E. coli barA (BARA_ECOLI); Fasta hit to BARA_ECOLI (918 aa), 90% identity in 921 aa overlap. (918 aa)
STY3354Probable two-component system response regulator; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity). (219 aa)
STY3507Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. (778 aa)
STY3711Transcriptional regulatory protein; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity). (441 aa)
STY3812Two-component response regulatory protein; Fasta hit to TORR_ECOLI (230 aa), 32% identity in 233 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 39% identity in 226 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 36% identity in 232 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 34% identity in 233 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 231 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 40% identity in 230 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 36% identity in 228 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 34% identity in 228 aa overlap; Fasta hit to PHOB_ECO [...] (232 aa)
STY3876Two-component system, response regulator; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
STY3951Two-component sensor protein histidine protein kinase; Orthologue of E. coli torS (TORS_ECOLI); Fasta hit to TORS_ECOLI (904 aa), 63% identity in 898 aa overlap. (911 aa)
STY3992Two-component system response regulator protein; Fasta hit to NARP_ECOLI (215 aa), 36% identity in 195 aa overlap; Fasta hit to UVRY_ECOLI (218 aa), 36% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 34% identity in 200 aa overlap; Orthologue of E. coli uhpA (UHPA_ECOLI); Fasta hit to UHPA_ECOLI (196 aa), 97% identity in 196 aa overlap. (196 aa)
ompRTwo-component response regulator OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in regulating expression of the outer membrane porins OmpC and OmpF as well as other genes. Unlike E.coli or S.typhimurium both porins are expressed constitutively. Involved in regulation of the biosynthesis of Vi polysaccharide, a capsular antigen thought to be involved in the virulence of S.typhi. Vi antigen is synthesized at low NaCl concentrations (under 0.4 M). Binds to the promoter of both ompC and ompF (By similarity). (239 aa)
pmrATwo-component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein PmrA or BasR SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 98.6% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 90.1% id in 222 aa. (222 aa)
dcuRTwo-component response regulator; Similar to Escherichia coli transcriptional regulatory protein DcuR SW:DCUR_ECOLI (P39271) (239 aa) fasta scores: E(): 0, 88.3% id in 239 aa, and to Bacillus subtilis two-component response regulator CitT TR:O34534 (EMBL:Z99108) (226 aa) fasta scores: E(): 5.2e-19, 31.4% id in 226 aa. Contains helix-turn-helix motif, residues 179 to 200, score 1148 (+3.10 SD). (239 aa)
STY4935Putative two-component response regulator; Similar to Escherichia coli transcriptional regulatory protein CreB SW:CREB_ECOLI (P08368) (229 aa) fasta scores: E(): 0, 83.4% id in 229 aa, and to Aeromonas jandaei response regulator protein BlrA TR:P97015 (EMBL:U67069) (223 aa) fasta scores: E(): 0, 62.8% id in 226 aa. (229 aa)
citBSimilar to Klebsiella pneumoniae transcriptional regulatory protein citb CITB SW:CITB_KLEPN (P52688) fasta scores: E(): 0, 84.6% id in 227 aa, and to Escherichia coli, and Shigella flexneri transcriptional regulatory protein dpia DPIA OR CITB OR MPDA OR CRIR SW:DPIA_ECOLI (Q54149) fasta scores: E(): 0, 47.3% id in 222 aa; Fasta hit to DCUR_ECOLI (239 aa), 30% identity in 225 aa overlap; Paralogue of E. coli criR (DPIA_ECOLI); Fasta hit to DPIA_ECOLI (226 aa), 47% identity in 222 aa overlap. (228 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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