STRINGSTRING
STY0426 STY0426 STY1655 STY1655 STY1785 STY1785 STY1789 STY1789 manX manX STY1960 STY1960 STY1961 STY1961 STY2193 STY2193 STY2292 STY2292 STY2293 STY2293 manB manB manC manC STY2320 STY2320 STY2321 STY2321 fbaB fbaB STY2439 STY2439 STY2441 STY2441 STY2519 STY2519 STY2521 STY2521 STY2564 STY2564 STY2953 STY2953 STY2954 STY2954 STY2955 STY2955 STY2956 STY2956 STY3113 STY3113 STY3116 STY3116 STY3117 STY3117 STY3226 STY3226 STY3436 STY3436 STY3437 STY3437 STY3785 STY3785 STY3789 STY3789 STY3809 STY3809 STY3826 STY3826 STY3827 STY3827 STY3925 STY3925 STY4110 STY4110 STY4111 STY4111 STY4137 STY4137 fbp fbp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0426Similar to Escherichia coli hypothetical 32.5 kDa protein in arom-araj intergenic region yajF SW:YAJF_ECOLI (P23917; P75705; P71316) (302 aa) fasta scores: E(): 0, 87.7% id in 300 aa, and to Staphylococcus xylosus glucokinase glkA SW:GLK_STAXY (Q56198) (328 aa) fasta scores: E(): 3.6e-16, 28.4% id in 320 aa; Fasta hit to YCFX_ECOLI (303 aa), 39% identity in 298 aa overlap; Orthologue of E. coli yajF (YAJF_ECOLI); Fasta hit to YAJF_ECOLI (302 aa), 88% identity in 300 aa overlap. (302 aa)
STY1655Mannose-6-phosphate isomerase; Orthologue of E. coli manA (MANA_ECOLI); Fasta hit to MANA_ECOLI (391 aa), 86% identity in 391 aa overlap; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa)
STY17856-phosphofructokinase isozyme; Fasta hit to K1PF_ECOLI (312 aa), 31% identity in 311 aa overlap; Orthologue of E. coli pfkB (K6P2_ECOLI); Fasta hit to K6P2_ECOLI (309 aa), 93% identity in 308 aa overlap; Belongs to the carbohydrate kinase PfkB family. (310 aa)
STY1789Putative hydrolase; Similar to Escherichia coli hypothetical 24.3 kDa protein in pfkB-cedA intergenic region yniC SW:YNIC_ECOLI (P77247) (222 aa) fasta scores: E(): 0, 89.6% id in 222 aa, and to Lactococcus lactis beta-phosphoglucomutase pgmB SW:PGMB_LACLA (P71447) (221 aa) fasta scores: E(): 1.7e-07, 26.5% id in 200 aa; Fasta hit to YQAB_ECOLI (188 aa), 33% identity in 184 aa overlap; Fasta hit to PGMB_ECOLI (219 aa), 30% identity in 195 aa overlap. (222 aa)
manXSimilar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 96.0% id in 322 aa. (322 aa)
STY1960Phosphotransferase enzyme II, C component; Orthologue of E. coli manY (PTNC_ECOLI); Fasta hit to PTNC_ECOLI (266 aa), 94% identity in 266 aa overlap. (266 aa)
STY1961Phosphotransferase enzyme II, D component; Fasta hit to PTPD_ECOLI (263 aa), 35% identity in 274 aa overlap; Orthologue of E. coli manZ (PTND_ECOLI); Fasta hit to PTND_ECOLI (286 aa), 93% identity in 282 aa overlap. (283 aa)
STY2193Conserved hypothetical protein; Orthologue of E. coli YEDP_ECOLI; Fasta hit to YEDP_ECOLI (271 aa), 76% identity in 269 aa overlap. (271 aa)
STY2292Phosphomannomutase; Similar to many e.g. Salmonella typhimurium phosphomannomutase SW:RFBK_SALTY (P26405) (477 aa) fasta scores: E(): 0, 98.7% id in 476 aa. (477 aa)
STY2293Similar to many e.g. Salmonella typhimurium mannose-1-phosphate guanylyltransferase SW:RFBM_SALTY (P26404) (479 aa) fasta scores: E(): 0, 98.7% id in 479 aa; Paralogue of E. coli cpsB (MANC_ECOLI); Fasta hit to MANC_ECOLI (478 aa), 59% identity in 469 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa)
manBPhosphomannomutase; Similar to Salmonella typhimurium LT2 phosphomannomutase manB or cpsG or rfbL SW:MANB_SALTY (P26341) (456 aa) fasta scores: E(): 0, 97.8% id in 456 aa; Orthologue of E. coli cpsG (MANB_ECOLI); Fasta hit to MANB_ECOLI (456 aa), 89% identity in 456 aa overlap. (456 aa)
manCSimilar to Salmonella typhimurium mannose-1-phosphate guanylyltransferase manC or cpsB or rfbM SW:MANC_SALTY (P26340) (480 aa) fasta scores: E(): 0, 99.8% id in 480 aa; Orthologue of E. coli cpsB (MANC_ECOLI); Fasta hit to MANC_ECOLI (478 aa), 91% identity in 478 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa)
STY2320GDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
STY2321GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa)
fbaBSimilar to Escherichia coli fructose-bisphosphate aldolase class I FbaB or DhnA SW:ALF1_ECOLI (P71295) (349 aa) fasta scores: E(): 0, 96.0% id in 349 aa; Orthologue of E. coli ALF1_ECOLI; Fasta hit to ALF1_ECOLI (349 aa), 96% identity in 349 aa overlap. (350 aa)
STY2439PTS system, fructose-specific IIBC component; Fasta hit to PTVB_ECOLI (485 aa), 34% identity in 478 aa overlap; Orthologue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 94% identity in 507 aa overlap. (562 aa)
STY24411-phosphofructokinase; Fasta hit to K6P2_ECOLI (309 aa), 31% identity in 310 aa overlap; Orthologue of E. coli fruK (K1PF_ECOLI); Fasta hit to K1PF_ECOLI (312 aa), 98% identity in 312 aa overlap; Belongs to the carbohydrate kinase PfkB family. (312 aa)
STY2519Putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa)
STY2521Putative MR-MLE-family protein; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). (405 aa)
STY2564Putative phosphatase; Similar to e.g. Saccharomyces cerevisiae GPP1 or RHR2 or YIL053W SW:GPP1_YEAST (P41277) (249 aa) fasta scores: E(): 3.9e-15, 34.2% id in 199 aa; Fasta hit to GPH_ECOLI (252 aa), 31% identity in 203 aa overlap; Orthologue of E. coli YFBT_ECOLI; Fasta hit to YFBT_ECOLI (222 aa), 87% identity in 221 aa overlap. (225 aa)
STY2953PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlA (PTHC_ECOLI); Fasta hit to PTHC_ECOLI (187 aa), 97% identity in 187 aa overlap. (187 aa)
STY2954PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlE (PTHB_ECOLI); Fasta hit to PTHB_ECOLI (319 aa), 93% identity in 323 aa overlap. (323 aa)
STY2955PTS system, glucitol/sorbitol-specific IIA component; Orthologue of E. coli srlB (PTHA_ECOLI); Fasta hit to PTHA_ECOLI (123 aa), 81% identity in 118 aa overlap. (120 aa)
STY2956Sorbitol-6-phosphate 2-dehydrogenase (glucitol-6-phosphate dehydrogenase); Fasta hit to YGFF_ECOLI (247 aa), 30% identity in 257 aa overlap; Fasta hit to HDHA_ECOLI (255 aa), 31% identity in 255 aa overlap; Orthologue of E. coli srlD (SRLD_ECOLI); Fasta hit to SRLD_ECOLI (259 aa), 97% identity in 259 aa overlap; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
STY3113Fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa)
STY3116L-fuculose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (576 aa)
STY3117L-fuculose kinase; Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family. (472 aa)
STY3226Fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
STY3436Possible carbohydrate kinase; Similar to Bacillus subtilis 1-phosphofructokinase fruk or fruB SW:K1PF_BACSU (O31714) (303 aa) fasta scores: E(): 9.9e-28, 31.8% id in 305 aa; Belongs to the carbohydrate kinase PfkB family. (304 aa)
STY3437Similar to Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (485 aa) fasta scores: E(): 0, 32.4% id in 475 aa. Note, like the example given, the predicted product of this CDS contains only one hydrophilic IIB domain. Contains possible membrane spanning hydrophobic domains; Fasta hit to PTVB_ECOLI (485 aa), 32% identity in 474 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 42% identity in 471 aa overlap. (475 aa)
STY3785Putative glycerol metabolic protein; Fasta hit to YGGF_ECOLI (321 aa), 57% identity in 318 aa overlap; Orthologue of E. coli glpX thought to be involved with glycerol metabolism (GLPX_ECOLI); Fasta hit to GLPX_ECOLI (336 aa), 95% identity in 336 aa overlap. (366 aa)
STY3789Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
STY38096-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
STY3826Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (489 aa)
STY3827L-rhamnose isomerase; Orthologue of E. coli rhaA (RHAA_ECOLI); Fasta hit to RHAA_ECOLI (419 aa), 94% identity in 418 aa overlap. (419 aa)
STY3925Similar to Escherichia coli PTS system, fructose-specific IIBC component SW:PTFB_ECOLI () (563 aa) fasta scores: E(): 0, 65.5% id in 458 aa. Note the product of this CDS lacks the first of the two E. coli EIIB transferase domains; Fasta hit to PTVB_ECOLI (485 aa), 35% identity in 450 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 66% identity in 458 aa overlap. (457 aa)
STY4110Mannitol-1-phosphate dehydrogenase; Orthologue of E. coli mtlD (MTLD_ECOLI); Fasta hit to MTLD_ECOLI (382 aa), 93% identity in 382 aa overlap. (382 aa)
STY4111Mannitol-specific enzyme II of phosphotransferase system; Orthologue of E. coli mtlA (PTMA_ECOLI); Fasta hit to PTMA_ECOLI (637 aa), 96% identity in 637 aa overlap. (638 aa)
STY4137D-xylose isomerase; Orthologue of E. coli xylA (XYLA_ECOLI); Fasta hit to XYLA_ECOLI (440 aa), 92% identity in 440 aa overlap; Belongs to the xylose isomerase family. (440 aa)
fbpFructose-1,6-bisphosphatase; Similar to Escherichia coli fructose-1,6-bisphosphatase fbp or fdP SW:F16P_ECOLI (P09200) (332 aa) fasta scores: E(): 0, 97.0% id in 332 aa, and to Haemophilus influenzae fructose-1,6-bisphosphatase fbp or hi1645 SW:F16P_HAEIN (P45292) (333 aa) fasta scores: E(): 0, 69.1% id in 333 aa. (332 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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