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STY0103 STY0103 STY0163 STY0163 STY0192 STY0192 STY0230 STY0230 STY0362 STY0362 STY0424 STY0424 STY0527 STY0527 STY0532 STY0532 STY0535 STY0535 allB allB STY0574 STY0574 allC allC allD allD arcC arcC STY0581 STY0581 STY0582 STY0582 STY0736 STY0736 STY1129 STY1129 STY1272 STY1272 STY1658 STY1658 STY1744 STY1744 STY1906 STY1906 STY2089 STY2089 STY2096 STY2096 STY2211 STY2211 STY2506 STY2506 STY2507 STY2507 STY2592 STY2592 STY2658 STY2658 STY2675 STY2675 STY2725 STY2725 STY2740 STY2740 STY2741 STY2741 STY2743 STY2743 STY2751 STY2751 STY2752 STY2752 STY2771 STY2771 STY2812 STY2812 STY2932 STY2932 STY2933 STY2933 STY3052 STY3052 cysC cysC cysN cysN cysD cysD STY3083 STY3083 relA relA STY3108 STY3108 STY3256 STY3256 STY3361 STY3361 STY3363 STY3363 STY3620 STY3620 STY3641 STY3641 STY3709 STY3709 STY3710 STY3710 STY3765 STY3765 spoT spoT STY4052 STY4052 yrfG yrfG yrfE yrfE purA purA cpdB cpdB nrdD nrdD STY4804 STY4804 STY4909 STY4909 deoB deoB deoD deoD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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STY0103Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (282 aa)
STY0163GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
STY0192Hypoxanthine phosphoribosyltransferase; Orthologue of E. coli hpt (HPRT_ECOLI); Fasta hit to HPRT_ECOLI (182 aa), 95% identity in 171 aa overlap; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa)
STY0230Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)
STY0362Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
STY0424Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
STY0527Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
STY0532Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
STY0535Inosine-guanosine kinase; Orthologue of E. coli gsk (INGK_ECOLI); Fasta hit to INGK_ECOLI (434 aa), 94% identity in 434 aa overlap. (434 aa)
allBPutative allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa)
STY0574Similar to Escherichia coli hypothetical 28.7 kDa protein in gip-fdra intergenic region (glxB6 TR:O54410 (EMBL:AE000157)) SW:YLBA_ECOLI (P75713) (261 aa) fasta scores: E(): 0, 92.3% id in 261 aa; Orthologue of E. coli YLBA_ECOLI; Fasta hit to YLBA_ECOLI (261 aa), 92% identity in 261 aa overlap. (261 aa)
allCSimilar to Escherichia coli allantoate amidohydrolase allc or glxb7 SW:ALLC_ECOLI (P77425) (411 aa) fasta scores: E(): 0, 88.1% id in 411 aa, and to Bacillus subtilis probable allantoate amidohydrolase yurH SW:ALLC_BACSU (O32149) (412 aa) fasta scores: E(): 0, 47.8% id in 404 aa; Orthologue of E. coli YLBB_ECOLI; Fasta hit to YLBB_ECOLI (411 aa), 88% identity in 411 aa overlap. (411 aa)
allDSimilar to Escherichia coli ureidoglycolate dehydrogenase alld or glxb8 SW:ALLD_ECOLI (P77555) (349 aa) fasta scores: E(): 0, 86.2% id in 349 aa, and to Methanothermus fervidus malate dehydrogenase mdH SW:MDH_METFE (P16142) (339 aa) fasta scores: E(): 0, 36.4% id in 343 aa; Orthologue of E. coli YLBC_ECOLI; Fasta hit to YLBC_ECOLI (349 aa), 86% identity in 349 aa overlap; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa)
arcCCarbamate kinase; Similar to Escherichia coli carbamate kinase arcC SW:ARCC_ECOLI (P37306; P77419) (297 aa) fasta scores: E(): 0, 86.9% id in 297 aa, and to Pseudomonas aeruginosa carbamate kinase arcC SW:ARCC_PSEAE (P13982) (310 aa) fasta scores: E(): 0, 52.7% id in 296 aa; Fasta hit to ARCM_ECOLI (316 aa), 40% identity in 317 aa overlap; Fasta hit to ARCL_ECOLI (310 aa), 40% identity in 315 aa overlap; Orthologue of E. coli ybcF (ARCC_ECOLI); Fasta hit to ARCC_ECOLI (297 aa), 87% identity in 297 aa overlap. (297 aa)
STY0581Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
STY0582Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
STY0736Phosphoglucomutase; Orthologue of E. coli pgm (PGMU_ECOLI); Fasta hit to PGMU_ECOLI (546 aa), 98% identity in 546 aa overlap. (546 aa)
STY1129Putative exported protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). (136 aa)
STY1272Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
STY1658Adenosine deaminase; Orthologue of E. coli add (ADD_ECOLI); Fasta hit to ADD_ECOLI (333 aa), 90% identity in 332 aa overlap; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
STY1744Pyruvate kinase; Fasta hit to KPY2_ECOLI (479 aa), 38% identity in 480 aa overlap; Orthologue of E. coli pykF (KPY1_ECOLI); Fasta hit to KPY1_ECOLI (470 aa), 96% identity in 470 aa overlap. (470 aa)
STY1906Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
STY2089Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa)
STY2096Pyruvate kinase A; Fasta hit to KPY1_ECOLI (470 aa), 37% identity in 480 aa overlap; Orthologue of E. coli pykA (KPY2_ECOLI); Fasta hit to KPY2_ECOLI (479 aa), 98% identity in 479 aa overlap; Belongs to the pyruvate kinase family. (480 aa)
STY2211AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (484 aa)
STY2506Ribonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa)
STY2507Similar to Salmonella typhimurium ribonucleoside-diphosphate reductase 1 beta chain nrdB SW:RIR2_SALTY (P37427) (375 aa) fasta scores: E(): 0, 99.7% id in 375 aa; Orthologue of E. coli nrdB (RIR2_ECOLI); Fasta hit to RIR2_ECOLI (375 aa), 98% identity in 375 aa overlap. (376 aa)
STY2592Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
STY2658Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (277 aa)
STY2675Putative amidotransferase; Similar, in part, to Salmonella typhimurium LT2 hypothetical protein yfeJ SW:YFEJ_SALTY (P40194) (170 aa) fasta scores: E(): 0, 89.0% id in 155 aa. The similarity ends due to a deletion in S. typhimurium with respect to S. typhi. Similar to Zymomonas mobilis hypothetical protein TR:Q9RQD2 (EMBL:AF117351) (251 aa) fasta scores: E(): 0, 53.1% id in 239 aa and Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:AAG03920 (EMBL:AE004489) (238 aa) fasta scores: E(): 2.1e-16, 31.9% id in 238 aa. (239 aa)
STY2725Phosphoribosylaminoimidazole-succinocarboxamide synthase; Orthologue of E. coli purC (PUR7_ECOLI); Fasta hit to PUR7_ECOLI (237 aa), 95% identity in 237 aa overlap; Belongs to the SAICAR synthetase family. (237 aa)
STY2740Phosphoribosylformylglycinamidine cyclo-ligase; Orthologue of E. coli purM (PUR5_ECOLI); Fasta hit to PUR5_ECOLI (344 aa), 91% identity in 344 aa overlap. (345 aa)
STY2741Phosphoribosylglycinamidine myltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
STY2743Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. (513 aa)
STY2751GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa)
STY2752Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
STY2771Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
STY2812Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
STY2932Ribonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa)
STY2933Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
STY3052Stationary-phase survival protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
cysCAdenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
cysNATP sulfurylase (ATP:sulfate adenyltransferase) subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
cysDATP sulfurylase (ATP:sulfate adenyltransferase); Orthologue of E. coli cysD (CYSD_ECOLI); Fasta hit to CYSD_ECOLI (302 aa), 97% identity in 302 aa overlap. (302 aa)
STY3083Conserved hypothetical protein; Orthologue of E. coli mazG (MAZG_ECOLI); Fasta hit to MAZG_ECOLI (263 aa), 94% identity in 262 aa overlap. (266 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa)
STY3108Conserved hypothetical protein; Orthologue of E. coli ygdH (YGDH_ECOLI); Fasta hit to YGDH_ECOLI (454 aa), 94% identity in 453 aa overlap. (454 aa)
STY3256Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
STY3361Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
STY3363Similar to Escherichia coli hypothetical protein YqiE SW:YQIE_ECOLI (P36651) (209 aa) fasta scores: E(): 0, 88.0% id in 208 aa. Also similar to Rhodobacter sphaeroides tellurite resistance protein TrgA TR:O07841 (EMBL:AF004296) (361 aa) fasta scores: E(): 3.8e-22, 38.3% id in 196 aa; Orthologue of E. coli YQIE_ECOLI; Fasta hit to YQIE_ECOLI (209 aa), 88% identity in 208 aa overlap. (210 aa)
STY3620Adenylate cyclase; Orthologue of E. coli cyaA (CYAA_ECOLI); Fasta hit to CYAA_ECOLI (848 aa), 96% identity in 848 aa overlap; Belongs to the adenylyl cyclase class-1 family. (848 aa)
STY3641Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (guanosine pentaphosphatase); Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (493 aa)
STY3709Phosphoribosylaminoimidazolecarboxamide formyltransferase; Orthologue of E. coli purH (PUR9_ECOLI); Fasta hit to PUR9_ECOLI (529 aa), 94% identity in 529 aa overlap. (529 aa)
STY3710Phosphoribosylglycineamide synthetase; Orthologue of E. coli purD (PUR2_ECOLI); Fasta hit to PUR2_ECOLI (429 aa), 94% identity in 429 aa overlap; Belongs to the GARS family. (429 aa)
STY3765Hypothetical protein; Similar to several 5' nucleosidase family proteins e.g. Thermotoga maritima UDP-sugar hydrolase TR:Q9X2J1 (EMBL:AE001824) (508 aa) fasta scores: E(): 1.1e-30, 32.6% id in 509 aa; Belongs to the 5'-nucleotidase family. (518 aa)
spoTGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa)
STY40525'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)
yrfGPutative hydrolase; Similar to Escherichia coli hypothetical 25.4 kDa protein in mrca-pcka intergenic region yrfG SW:YRFG_ECOLI (P45801) (222 aa) fasta scores: E(): 0, 85.5% id in 221 aa, and to Pseudomonas sp 2-haloalkanoic acid dehalogenase SW:HAD_PSESP (Q53464) (232 aa) fasta scores: E(): 0.0029, 27.8% id in 144 aa. (236 aa)
yrfEPutative NUDIX hydrolase; Similar to Escherichia coli hypothetical 21.2 kDa protein in mrca-pcka intergenic region yrfE SW:YRFE_ECOLI (P45799) (186 aa) fasta scores: E(): 0, 92.5% id in 186 aa. (198 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
cpdBSimilar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor cpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 0, 90.3% id in 647 aa; Belongs to the 5'-nucleotidase family. (647 aa)
nrdDSimilar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase nrdD SW:NRDD_ECOLI (P28903) (712 aa) fasta scores: E(): 0, 96.2% id in 712 aa. (712 aa)
STY4804Carbamate kinase; Similar to Pseudomonas aeruginosa carbamate kinase SW:ARCC_PSEAE (P13982) (310 aa) fasta scores: E(): 0, 54.6% id in 306 aa, and to Synechocystis sp carbamate kinase SW:ARCC_SYNY3 (P74733) (308 aa) fasta scores: E(): 0, 53.5% id in 301 aa. (310 aa)
STY4909Similar to Escherichia coli hypothetical 25.3 kDa protein in rimI-prfC intergenic region YjjG SW:YJJG_ECOLI (P33999; P76818) (225 aa) fasta scores: E(): 0, 90.7% id in 225 aa, and to Bacillus subtilis YfnB TR:O06480 (EMBL:D86418) (235 aa) fasta scores: E(): 6.9e-17, 28.6% id in 227 aa. (226 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoDSimilar to Escherichia coli purine nucleoside phosphorylase deod or puP SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 97.1% id in 238 aa. (239 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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