STRINGSTRING
STY0002 STY0002 STY0187 STY0187 STY0188 STY0188 mtn mtn STY0501 STY0501 STY0977 STY0977 STY1000 STY1000 STY1507 STY1507 STY1956 STY1956 STY1978 STY1978 STY2161 STY2161 STY2200 STY2200 STY2430 STY2430 STY2666 STY2666 STY2677 STY2677 STY2779 STY2779 luxS luxS STY2944 STY2944 STY3110 STY3110 STY3218 STY3218 STY3243 STY3243 STY3248 STY3248 STY3333 STY3333 tdcG tdcG STY3539 STY3539 STY3594 STY3594 STY3654 STY3654 STY3768 STY3768 STY3769 STY3769 cysE cysE STY4271 STY4271 metA metA STY4405 STY4405 STY4416 STY4416 STY4444 STY4444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0002Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
STY0187S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa)
STY0188Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (286 aa)
mtnMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa)
STY0501Putative lyase; Similar to Mycobacterium tuberculosis putative lyase rv3684 or mtv025.032 TR:O69652 (EMBL:AL022121) (346 aa) fasta scores: E(): 0, 61.5% id in 338 aa, and to Cyanidioschyzon merolae O-acetylserine cmoastl2 TR:Q9SSV8 (EMBL:AB031004) (390 aa) fasta scores: E(): 2.3e-16, 27.4% id in 329 aa, and to Emericella nidulans cysteine synthase cysB SW:CYSK_EMENI (P50867) (371 aa) fasta scores: E(): 1.7e-14, 25.6% id in 332 aa. (351 aa)
STY0977Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
STY1000Aspartate aminotransferase; Fasta hit to TYRB_ECOLI (397 aa), 43% identity in 397 aa overlap; Orthologue of E. coli aspC (AAT_ECOLI); Fasta hit to AAT_ECOLI (396 aa), 96% identity in 396 aa overlap; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
STY1507Putative aminotransferase; Orthologue of E. coli malY (MALY_ECOLI); Fasta hit to MALY_ECOLI (390 aa), 34% identity in 384 aa overlap. (393 aa)
STY1956L-serine deaminase 1; Orthologue of E. coli sdaA (SDHL_ECOLI); Fasta hit to SDHL_ECOLI (454 aa), 94% identity in 454 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
STY1978Similar to Escherichia coli hypothetical 20.3 kDa protein in prc-pphA intergenic region SW:YEBR_ECOLI (P76270) (183 aa) fasta scores: E(): 0, 83.8% id in 173 aa, and to Zymomonas mobilis hypothetical 17.7 kDa protein in lpd 3'region SW:YLP6_ZYMMO (O66116) (161 aa) fasta scores: E(): 2e-22, 41.5% id in 147 aa. (194 aa)
STY2161Putative deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa)
STY2200DNA-cytosine methyltransferase; Orthologue of E. coli dcm (DCM_ECOLI); Fasta hit to DCM_ECOLI (472 aa), 83% identity in 477 aa overlap. (476 aa)
STY2430Putative L-serine dehydratase; Fasta hit to SDHM_ECOLI (455 aa), 50% identity in 452 aa overlap; Fasta hit to TDCG_ECOLI (454 aa), 51% identity in 450 aa overlap; Paralogue of E. coli sdaA (SDHL_ECOLI); Fasta hit to SDHL_ECOLI (454 aa), 49% identity in 453 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
STY2666Cysteine synthase A; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product (By similarity). (323 aa)
STY2677Cysteine synthase B; Similar to Salmonella typhimurium LT2 cysteine synthase B cysM SW:CYSM_SALTY (P29848) (303 aa) fasta scores: E(): 0, 98.7% id in 303 aa; Fasta hit to CYSK_ECOLI (322 aa), 44% identity in 307 aa overlap; Orthologue of E. coli cysM (CYSM_ECOLI); Fasta hit to CYSM_ECOLI (303 aa), 93% identity in 303 aa overlap; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
STY2779Putative thiosulfate sulfurtransferase; Similar to many eukaryotic proteins e.g. Homo sapiens 3-mercaptopyruvate sulfurtransferase mpsT or tst2 SW:THTM_HUMAN (P25325) (296 aa) fasta scores: E(): 0, 41.1% id in 280 aa; Orthologue of E. coli sseA (THTR_ECOLI); Fasta hit to THTR_ECOLI (280 aa), 81% identity in 278 aa overlap. (280 aa)
luxSAutoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
STY2944Gamma-glutamylcysteine synthetase; Similar to Salmonella typhimurium LT2 glutamate--cysteine ligase SW:GSH1_SALTY (O68838) (518 aa) fasta scores: E(): 0, 98.6% id in 518 aa; Orthologue of E. coli gshA (GSH1_ECOLI); Fasta hit to GSH1_ECOLI (518 aa), 93% identity in 518 aa overlap; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
STY3110L-serine dehydratase 2 (L-serine deaminase 2); Fasta hit to TDCG_ECOLI (454 aa), 73% identity in 454 aa overlap; Fasta hit to SDHL_ECOLI (454 aa), 77% identity in 455 aa overlap; Orthologue of E. coli sdaB (SDHM_ECOLI); Fasta hit to SDHM_ECOLI (455 aa), 94% identity in 455 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
STY3218D-3-phosphoglycerate dehydrogenase; Orthologue of E. coli serA (SERA_ECOLI); Fasta hit to SERA_ECOLI (409 aa), 96% identity in 409 aa overlap; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
STY3243S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
STY3248Glutathione synthetase; Orthologue of E. coli gshB (GSHB_ECOLI); Fasta hit to GSHB_ECOLI (316 aa), 90% identity in 315 aa overlap. (315 aa)
STY3333Beta-cystathionase; Fasta hit to METB_ECOLI (386 aa), 32% identity in 398 aa overlap; Orthologue of E. coli metC (METC_ECOLI); Fasta hit to METC_ECOLI (395 aa), 87% identity in 395 aa overlap. (395 aa)
tdcGSimilar to Escherichia coli L-serine dehydratase TdcG SW:TDCG_ECOLI () (454 aa) fasta scores: E(): 0, 86.6% id in 454 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
STY3539Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
STY35945-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
STY3654Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. (309 aa)
STY3768Bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write; Fasta hit to AK1H_ECOLI (820 aa), 30% identity in 823 aa overlap; Orthologue of E. coli metL (AK2H_ECOLI); Fasta hit to AK2H_ECOLI (809 aa), 94% identity in 809 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
STY3769Cystathionine gamma-synthase; Fasta hit to METC_ECOLI (395 aa), 31% identity in 394 aa overlap; Orthologue of E. coli metB (METB_ECOLI); Fasta hit to METB_ECOLI (386 aa), 96% identity in 386 aa overlap. (386 aa)
cysESimilar to Escherichia coli serine acetyltransferase cysE SW:CYSE_ECOLI (P05796) (273 aa) fasta scores: E(): 0, 95.6% id in 273 aa; Belongs to the transferase hexapeptide repeat family. (273 aa)
STY4271Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
metAHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa)
STY4405B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
STY4416Similar to Escherichia coli lysine-sensitive aspartokinase III LysC SW:AK3_ECOLI (P08660) (449 aa) fasta scores: E(): 0, 93.3% id in 449 aa; Belongs to the aspartokinase family. (449 aa)
STY4444Similar to Salmonella typhimurium aromatic-amino-acid aminotransferase SW:TYRB_SALTY (P74861) (397 aa) fasta scores: E(): 0, 98.0% id in 397 aa, and to Escherichia coli aromatic-amino-acid aminotransferase tyrB SW:TYRB_ECOLI (P04693) (397 aa) fasta scores: E(): 0, 88.9% id in 397 aa. (397 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.