STRINGSTRING
STY0177 STY0177 STY0259 STY0259 STY0780 STY0780 STY1467 STY1467 STY2590 STY2590 STY2620 STY2620 STY2806 STY2806 STY2909 STY2909 STY2910 STY2910 STY2911 STY2911 STY2912 STY2912 yqeF yqeF STY3396 STY3396 STY3577 STY3577
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0177Dihydrolipoamide dehydrogenase; Orthologue of E. coli lpdA (DLDH_ECOLI); Fasta hit to DLDH_ECOLI (473 aa), 98% identity in 473 aa overlap. (475 aa)
STY0259Lysine decarboxylase; Fasta hit to ADI_ECOLI (755 aa), 35% identity in 720 aa overlap; Fasta hit to DCOS_ECOLI (732 aa), 32% identity in 694 aa overlap; Fasta hit to DCOR_ECOLI (731 aa), 35% identity in 626 aa overlap; Fasta hit to DCLY_ECOLI (715 aa), 71% identity in 710 aa overlap; Orthologue of E. coli ldcC (DCLZ_ECOLI); Fasta hit to DCLZ_ECOLI (713 aa), 91% identity in 712 aa overlap. (713 aa)
STY0780Dihydrolipoamide succinyltransferase component (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
STY1467Putative aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (481 aa)
STY2590Similar to Bacillus methanolicus diaminopimelate decarboxylase lysA SW:DCDA_BACMT (P41023) (432 aa) fasta scores: E(): 4.8e-21, 28.3% id in 438 aa and to many putative diaminopimelate decarboxylases. (465 aa)
STY2620Putative fatty acid oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa)
STY2806Similar to Salmonella typhimurium lysine decarboxylase, inducible SW:DCLY_SALTY (Q60002) (715 aa) fasta scores: E(): 0, 97.5% id in 715 aa; Fasta hit to DCOS_ECOLI (732 aa), 33% identity in 623 aa overlap; Fasta hit to ADI_ECOLI (755 aa), 36% identity in 740 aa overlap; Fasta hit to DCLZ_ECOLI (713 aa), 70% identity in 710 aa overlap; Fasta hit to DCOR_ECOLI (731 aa), 34% identity in 616 aa overlap; Orthologue of E. coli cadA (DCLY_ECOLI); Fasta hit to DCLY_ECOLI (715 aa), 92% identity in 714 aa overlap; Belongs to the Orn/Lys/Arg decarboxylase class-I family. (714 aa)
STY2909Gab protein homolog; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (328 aa)
STY2910Putative GAB DTP gene cluster repressor; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2 [...] (422 aa)
STY2911Succinate-semialdehyde dehydrogenase; Fasta hit to ALDA_ECOLI (478 aa), 39% identity in 464 aa overlap; Fasta hit to FEAB_ECOLI (499 aa), 36% identity in 480 aa overlap; Fasta hit to YNEI_ECOLI (462 aa), 32% identity in 445 aa overlap; Fasta hit to ALDB_ECOLI (512 aa), 33% identity in 490 aa overlap; Fasta hit to DHAB_ECOLI (489 aa), 37% identity in 481 aa overlap; Fasta hit to DHAL_ECOLI (495 aa), 34% identity in 485 aa overlap; Fasta hit to ASTD_ECOLI (492 aa), 32% identity in 470 aa overlap; Fasta hit to YDCW_ECOLI (474 aa), 37% identity in 477 aa overlap; Orthologue of E. coli gabD [...] (482 aa)
STY29124-aminobutyrate aminotransferase; Fasta hit to GSA_ECOLI (426 aa), 32% identity in 421 aa overlap; Fasta hit to ARGM_ECOLI (406 aa), 34% identity in 404 aa overlap; Fasta hit to ARGD_ECOLI (405 aa), 36% identity in 411 aa overlap; Fasta hit to BIOA_ECOLI (429 aa), 32% identity in 353 aa overlap; Fasta hit to GOAG_ECOLI (421 aa), 53% identity in 421 aa overlap; Orthologue of E. coli gabT (GABT_ECOLI); Fasta hit to GABT_ECOLI (426 aa), 89% identity in 426 aa overlap; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
yqeFSimilar to Escherichia coli probable acetyl-CoA acetyltransferase YqeF SW:YQEF_ECOLI (Q46939) (393 aa) fasta scores: E(): 0, 91.5% id in 388 aa; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
STY3396Probable aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (429 aa)
STY3577Large (alpha) subunit of the fatty acid-oxidizing multienzyme complex; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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