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STY0177 STY0177 STY0181 STY0181 gcl gcl hyi hyi garR garR glxK glxK STY0773 STY0773 STY1172 STY1172 STY1294 STY1294 STY1339 STY1339 STY1793 STY1793 STY2730 STY2730 STY2802 STY2802 STY3097 STY3097 STY3112 STY3112 yqeF yqeF STY3209 STY3209 STY3210 STY3210 STY3211 STY3211 STY3429 STY3429 garR-2 garR-2 STY3534 STY3534 STY3535 STY3535 STY3539 STY3539 STY3764 STY3764 fdoG fdoG STY3841 STY3841 STY3842 STY3842 STY3874 STY3874 STY4156 STY4156 gph gph STY4401 STY4401 STY4402 STY4402 acs acs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0177Dihydrolipoamide dehydrogenase; Orthologue of E. coli lpdA (DLDH_ECOLI); Fasta hit to DLDH_ECOLI (473 aa), 98% identity in 473 aa overlap. (475 aa)
STY0181Aconitate hydratase 2 (citrate hydro-lyase 2); Orthologue of E. coli acnB (ACO2_ECOLI); Fasta hit to ACO2_ECOLI (865 aa), 96% identity in 865 aa overlap; Belongs to the aconitase/IPM isomerase family. (865 aa)
gclSimilar to Escherichia coli glyoxylate carboligase SW:GCL_ECOLI () (592 aa) fasta scores: E(): 0, 95.8% id in 592 aa, and to Corynebacterium glutamicum acetolactate synthase large subunit ilvB SW:ILVB_CORGL (P42463) (626 aa) fasta scores: E(): 0, 37.8% id in 561 aa; Belongs to the TPP enzyme family. (593 aa)
hyiGlyoxylate-induced protein; Similar to Escherichia coli hydroxypyruvate isomerase hyi or giP SW:HYI_ECOLI (P30147) (258 aa) fasta scores: E(): 0, 84.1% id in 258 aa; Fasta hit to YGBM_ECOLI (258 aa), 39% identity in 258 aa overlap; Orthologue of E. coli gip (GIP_ECOLI); Fasta hit to GIP_ECOLI (258 aa), 84% identity in 258 aa overlap; Belongs to the hyi family. (258 aa)
garRSimilar to Escherichia coli 2-hydroxy-3-oxopropionate reductase garr or b3125 SW:GARR_ECOLI (P23523) (294 aa) fasta scores: E(): 0, 42.9% id in 289 aa; Fasta hit to YIHU_ECOLI (298 aa), 31% identity in 290 aa overlap; Fasta hit to YHAE_ECOLI (294 aa), 43% identity in 289 aa overlap; Orthologue of E. coli YBBQ_ECOLI; Fasta hit to YBBQ_ECOLI (292 aa), 91% identity in 292 aa overlap. (292 aa)
glxKGlycerate kinase; Similar to Escherichia coli glycerate kinase glxk or glxb5 SW:GLXK_ECOLI (P77364) (381 aa) fasta scores: E(): 0, 79.9% id in 379 aa, and to Escherichia coli glycerate kinase garK SW:GARK_ECOLI (P23524) (381 aa) fasta scores: E(): 0, 57.4% id in 376 aa; Fasta hit to YHAD_ECOLI (381 aa), 57% identity in 376 aa overlap; Orthologue of E. coli YBBZ_ECOLI; Fasta hit to YBBZ_ECOLI (381 aa), 80% identity in 379 aa overlap; Belongs to the glycerate kinase type-1 family. (382 aa)
STY0773Citrate synthase; Fasta hit to CISZ_ECOLI (389 aa), 31% identity in 369 aa overlap; Orthologue of E. coli gltA (CISY_ECOLI); Fasta hit to CISY_ECOLI (427 aa), 96% identity in 427 aa overlap; Belongs to the citrate synthase family. (427 aa)
STY1172Putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
STY1294Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa)
STY1339Aconitate hydratase 1 (citrate hydro-lyase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
STY1793Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa)
STY2730Similar to Bacillus subtilis hypothetical protein yxaA SW:YXAA_BACSU (P42100) (382 aa) fasta scores: E(): 0, 58.2% id in 378 aa and Haemophilus influenzae hypothetical protein HI0091 SW:YHAD_HAEIN (P44507) (378 aa) fasta scores: E(): 0, 58.9% id in 372 aa; Fasta hit to YBBZ_ECOLI (381 aa), 55% identity in 377 aa overlap; Paralogue of E. coli yhaD (YHAD_ECOLI); Fasta hit to YHAD_ECOLI (381 aa), 60% identity in 371 aa overlap; Belongs to the glycerate kinase type-1 family. (379 aa)
STY2802Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
STY3097Conserved hypothetical protein; Fasta hit to YBBZ_ECOLI (381 aa), 58% identity in 380 aa overlap; Paralogue of E. coli yhaD (YHAD_ECOLI); Fasta hit to YHAD_ECOLI (381 aa), 69% identity in 378 aa overlap; Belongs to the glycerate kinase type-1 family. (380 aa)
STY31121,2-propanediol oxidoreductase (lactaldehyde reductase); Fasta hit to EUTG_ECOLI (395 aa), 40% identity in 372 aa overlap; Fasta hit to ADH2_ECOLI (383 aa), 44% identity in 371 aa overlap; Orthologue of E. coli fucO (FUCO_ECOLI); Fasta hit to FUCO_ECOLI (383 aa), 91% identity in 382 aa overlap. (382 aa)
yqeFSimilar to Escherichia coli probable acetyl-CoA acetyltransferase YqeF SW:YQEF_ECOLI (Q46939) (393 aa) fasta scores: E(): 0, 91.5% id in 388 aa; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
STY3209Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
STY3210Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
STY3211Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
STY3429Conserved hypothetical protein; Fasta hit to YBBZ_ECOLI (381 aa), 56% identity in 376 aa overlap; Orthologue of E. coli yhaD (YHAD_ECOLI); Fasta hit to YHAD_ECOLI (381 aa), 86% identity in 381 aa overlap; Belongs to the glycerate kinase type-1 family. (381 aa)
garR-22-hydroxy-3-oxopropionate reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (294 aa)
STY3534Tartrate dehydratase; Orthologue of E. coli ttdB (TTDB_ECOLI); Fasta hit to TTDB_ECOLI (201 aa), 67% identity in 203 aa overlap. (205 aa)
STY3535Tartrate dehydratase; Orthologue of E. coli ttdA (TTDA_ECOLI); Fasta hit to TTDA_ECOLI (303 aa), 54% identity in 294 aa overlap. (299 aa)
STY3539Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
STY3764Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
fdoGHighly similar to Escherichia coli formate dehydrogenase-O, major subunit fdoG SW:FDOG_ECOLI (P32176; P78131) (1016 aa). Contains a stop codon (codon 196) which is encoded as a selenocysteine by the opal codon UGA. (1016 aa)
STY3841Formate dehydrogenase-O beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
STY3842Formate dehydrogenase-O gamma subunit; Fasta hit to FDNI_ECOLI (217 aa), 49% identity in 214 aa overlap; Orthologue of E. coli fdoI (FDOI_ECOLI); Fasta hit to FDOI_ECOLI (211 aa), 96% identity in 211 aa overlap. (211 aa)
STY3874Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
STY4156Putative 2-hydroxyacid dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (252 aa)
STY4401Similar to Escherichia coli malate synthase A AceB SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 90.8% id in 533 aa, and to Myxococcus xanthus malate synthase mls SW:MASY_MYXXA (P95329) (541 aa) fasta scores: E(): 0, 56.2% id in 511 aa. (533 aa)
STY4402Isocitrate lyase; Similar to Escherichia coli isocitrate lyase AceA SW:ACEA_ECOLI (P05313) (434 aa) fasta scores: E(): 0, 95.6% id in 434 aa, and to Vibrio cholerae isocitrate lyase VC0736 TR:Q9KTZ4 (EMBL:AE004159) (437 aa) fasta scores: E(): 0, 79.4% id in 433 aa. (434 aa)
acsAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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