STRINGSTRING
STY0008 STY0008 STY0102 STY0102 STY0208 STY0208 ybaX ybaX STY0836 STY0836 STY0837 STY0837 STY0838 STY0838 STY0840 STY0840 STY0885 STY0885 STY1237 STY1237 STY1340 STY1340 STY1954 STY1954 STY2108 STY2108 STY2427 STY2427 STY2596 STY2596 STY3077 STY3077 STY3078 STY3078 STY3080 STY3080 STY3107 STY3107 folB folB STY3473 STY3473 STY3886 STY3886 pabA pabA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0008Molybdopterin biosynthesis Mog protein; Orthologue of E. coli mog (MOG_ECOLI); Fasta hit to MOG_ECOLI (195 aa), 94% identity in 192 aa overlap. (196 aa)
STY0102Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
STY02082-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase; Orthologue of E. coli folK (HPPK_ECOLI); Fasta hit to HPPK_ECOLI (158 aa), 82% identity in 158 aa overlap. (159 aa)
ybaXConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
STY0836Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
STY0837Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
STY0838Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa)
STY0840Molybdopterin converting factor, subunit 2; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family. (150 aa)
STY0885Molybdopterin biosynthesis MoeA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (413 aa)
STY12374-amino-4-deoxychorismate lyase; Orthologue of E. coli pabC (PABC_ECOLI); Fasta hit to PABC_ECOLI (269 aa), 70% identity in 269 aa overlap. (269 aa)
STY1340GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa)
STY1954Para-aminobenzoate synthase component I; Orthologue of E. coli pabB (PABB_ECOLI); Fasta hit to PABB_ECOLI (453 aa), 76% identity in 452 aa overlap. (454 aa)
STY2108DATP pyrophosphohydrolase; Orthologue of E. coli ntpA (NTPA_ECOLI); Fasta hit to NTPA_ECOLI (150 aa), 88% identity in 146 aa overlap. (150 aa)
STY2427GTP cyclohydrolase I; Orthologue of E. coli folE (GCH1_ECOLI); Fasta hit to GCH1_ECOLI (221 aa), 96% identity in 220 aa overlap; Belongs to the GTP cyclohydrolase I family. (222 aa)
STY2596Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
STY3077Highly similar to Escherichia coli putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM SW:PTPS_ECOLI (Q46903) (121 aa) fasta scores: E(): 0, 94.2% id in 120 aa; Orthologue of E. coli PTPS_ECOLI; Fasta hit to PTPS_ECOLI (121 aa), 94% identity in 120 aa overlap. (120 aa)
STY3078MBL fold metallo-hydrolase; Similar to hypothetical proteins of archeal origin e.g. Pyrococcus abyssi hypothetical 30.2 kDa protein pab0518 TR:Q9V0M3 (EMBL:AJ248285) (272 aa) fasta scores: E(): 3.5e-26, 38.7% id in 261 aa, and to Methanobacterium thermoautotrophicum conserved protein mth1101 TR:O27173 (EMBL:AE000880) (260 aa) fasta scores: E(): 2.3e-16, 31.5% id in 251 aa, and to Methanococcus jannaschii hypothetical protein Mj0448 mj0448 SW:Y448_METJA (Q57890) (256 aa) fasta scores: E(): 7.3e-15, 29.4% id in 248 aa, and to Archaeoglobus fulgidus conserved hypothetical protein af0719 T [...] (265 aa)
STY3080Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)
STY3107Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
STY3473Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
STY3886Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa)
pabASimilar to Salmonella typhimurium para-aminobenzoate synthase glutamine amidotransferase component ii pabA SW:PABA_SALTY (P06193) (187 aa) fasta scores: E(): 0, 99.5% id in 187 aa, and to Escherichia coli para-aminobenzoate synthase glutamine amidotransferase component ii pabA SW:PABA_ECOLI (P00903) (187 aa) fasta scores: E(): 0, 85.0% id in 187 aa. (187 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.