STRINGSTRING
STY2124 STY2124 STY2125 STY2125 STY2126 STY2126 STY2127 STY2127 STY2128 STY2128 STY2129 STY2129 STY2130 STY2130 STY2131 STY2131 STY2132 STY2132 STY2178 STY2178 STY2184 STY2184 STY2185 STY2185 STY2424 STY2424 STY2545 STY2545 cheM cheM STY3395 STY3395 STY3894 STY3894 STY4168 STY4168 STY4234 STY4234 STY4425 STY4425
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY2124Chemotaxis protein CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (214 aa)
STY2125Chemotaxis protein CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). (129 aa)
STY2126Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
STY2127Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (288 aa)
STY2128Similar to Salmonella typhimurium methyl-accepting chemotaxis protein II tar SW:MCP2_SALTY (P02941) (553 aa) fasta scores: E(): 0, 98.7% id in 553 aa. Contains a possible N-terminal signal sequence and hydrophobic, probable membrane-spanning region; Fasta hit to MCP3_ECOLI (546 aa), 47% identity in 523 aa overlap; Fasta hit to MCP4_ECOLI (533 aa), 48% identity in 523 aa overlap; Fasta hit to MCP1_ECOLI (551 aa), 59% identity in 557 aa overlap; Orthologue of E. coli tar (MCP2_ECOLI); Fasta hit to MCP2_ECOLI (553 aa), 79% identity in 554 aa overlap. (553 aa)
STY2129Similar to many e.g. Salmonella typhimurium chemotaxis protein CheW cheW SW:CHEW_SALTY (P06110) (167 aa) fasta scores: E(): 0, 99.4% id in 167 aa; Orthologue of E. coli cheW (CHEW_ECOLI); Fasta hit to CHEW_ECOLI (167 aa), 92% identity in 167 aa overlap. (167 aa)
STY2130Chemotaxis protein CheA; Similar to many e.g. Salmonella typhimurium chemotaxis protein CheA cheA SW:CHEA_SALTY (P09384) (671 aa) fasta scores: E(): 0, 99.4% id in 671 aa; Orthologue of E. coli cheA (CHEA_ECOLI); Fasta hit to CHEA_ECOLI (654 aa), 85% identity in 672 aa overlap. (671 aa)
STY2131Motility protein B; Similar to e.g. Salmonella typhimurium chemotaxis motB protein SW:MOTB_SALTY (P55892) (309 aa) fasta scores: E(): 0, 99.7% id in 309 aa. Contains hydrophobic, probable membrane-spanning region; Orthologue of E. coli MotB (MOTB_ECOLI); Fasta hit to MOTB_ECOLI (308 aa), 90% identity in 309 aa overlap. (309 aa)
STY2132Motility protein A; Identical to Salmonella typhimurium chemotaxis MotA protein motA SW:MOTA_SALTY (P55891) (295 aa) fasta scores: E(): 0, 99.3% id in 295 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli motA (MOTA_ECOLI); Fasta hit to MOTA_ECOLI (295 aa), 93% identity in 295 aa overlap. (295 aa)
STY2178Flagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (331 aa)
STY2184Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (334 aa)
STY2185Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
STY2424Similar to Salmonella typhimurium D-galactose-binding periplasmic protein precursor mglB SW:DGAL_SALTY (P23905) (332 aa) fasta scores: E(): 0, 99.1% id in 332 aa; Orthologue of E. coli mglB (DGAL_ECOLI); Fasta hit to DGAL_ECOLI (332 aa), 93% identity in 332 aa overlap. (332 aa)
STY2545Putative receptor/regulator protein; Shows weak similarity to Bacillus subtilis chemotaxis CheV protein cheV SW:CHEV_BACSU (P37599) (303 aa) fasta scores: E(): 2.7e-17, 31.4% id in 299 aa and e.g. Vibrio parahaemolyticus chemotaxis CheV homolog cheV TR:Q9X9K3 (EMBL:U12817) (308 aa) fasta scores: E(): 5.7e-26, 32.6% id in 322 aa. (334 aa)
cheMSimilar to many including: Escherichia coli methyl-accepting chemotaxis protein II Tar or CheM SW:MCP2_ECOLI (P07017; P76301) (553 aa) fasta scores: E(): 0, 34.7% id in 519 aa; Fasta hit to MCP3_ECOLI (546 aa), 35% identity in 524 aa overlap; Fasta hit to MCP4_ECOLI (533 aa), 33% identity in 525 aa overlap; Fasta hit to MCP1_ECOLI (551 aa), 37% identity in 531 aa overlap; Paralogue of E. coli tar (MCP2_ECOLI); Fasta hit to MCP2_ECOLI (553 aa), 35% identity in 519 aa overlap. (522 aa)
STY3395Aerotaxis receptor protein; Orthologue of E. coli air (AER_ECOLI); Fasta hit to AER_ECOLI (506 aa), 84% identity in 506 aa overlap. (506 aa)
STY3894D-ribose-binding periplasmic protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. (296 aa)
STY4168Periplasmic dipeptide transport protein precursor; Fasta hit to SAPA_ECOLI (547 aa), 36% identity in 513 aa overlap; Orthologue of E. coli dppA (DPPA_ECOLI); Fasta hit to DPPA_ECOLI (535 aa), 93% identity in 535 aa overlap. (535 aa)
STY4234Similar to Salmonella typhimurium methyl-accepting chemotaxis citrate transducer tcp SW:MCPC_SALTY (Q02755) (547 aa) fasta scores: E(): 0, 99.8% id in 547 aa, and to Escherichia coli methyl-accepting chemotaxis protein I CheD SW:MCP1_ECOLI (P02942) (551 aa) fasta scores: E(): 0, 53.4% id in 554 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (547 aa)
STY4425Periplasmic maltose-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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