STRINGSTRING
STY0723 STY0723 STY0917 STY0917 STY0918 STY0918 STY1242 STY1242 STY1448 STY1448 STY1450 STY1450 STY1451 STY1451 STY1799 STY1799 celB celB STY1801 STY1801 manX manX STY1960 STY1960 STY1961 STY1961 STY2439 STY2439 STY2441 STY2441 STY2442 STY2442 STY2572 STY2572 STY2573 STY2573 STY2574 STY2574 STY2667 STY2667 STY2670 STY2670 STY2816 STY2816 STY2953 STY2953 STY2954 STY2954 STY2955 STY2955 STY3144 STY3144 STY3437 STY3437 STY3438 STY3438 STY3441 STY3441 STY3442 STY3442 STY3443 STY3443 ptsN ptsN STY3503 STY3503 STY3925 STY3925 STY3999 STY3999 STY4000 STY4000 STY4004 STY4004 STY4013 STY4013 STY4014 STY4014 STY4015 STY4015 STY4016 STY4016 STY4111 STY4111 sgaT sgaT sgaB sgaB sgaA sgaA treB treB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0723Pts system, N-acetylglucosamine-specific IIABC component; Orthologue of E. coli nagE (PTAA_ECOLI); Fasta hit to PTAA_ECOLI (648 aa), 93% identity in 648 aa overlap. (650 aa)
STY0917Possible transport protein; Similar to Escherichia coli putative transport protein SgaT sgaT SW:SGAT_ECOLI (P39301) (484 aa) fasta scores: E(): 0, 39.0% id in 431 aa, and to Mycoplasma pneumoniae sgat protein homolog SW:SGAT_MYCPN (P75291) (660 aa) fasta scores: E(): 4e-09, 29.0% id in 428 aa; Paralogue of E. coli yjfS (SGAT_ECOLI); Fasta hit to SGAT_ECOLI (484 aa), 39% identity in 431 aa overlap. (447 aa)
STY0918Similar to Escherichia coli unknown pentitol phosphotransferase enzyme ii, b component sgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.00016, 25.3% id in 99 aa, and to Borrelia burgdorferi pts system, cellobiose-specific iib component bbb06 TR:O50982 (EMBL:AE000792) (105 aa) fasta scores: E(): 0.92, 28.6% id in 105 aa. (106 aa)
STY1242PTS system, glucose-specific IIBC component; Fasta hit to PTOA_ECOLI (530 aa), 37% identity in 513 aa overlap; Orthologue of E. coli ptsG (PTGB_ECOLI); Fasta hit to PTGB_ECOLI (477 aa), 97% identity in 476 aa overlap. (477 aa)
STY1448Putative phosphotransferase enzyme; Fasta hit to PTXA_ECOLI (154 aa), 34% identity in 125 aa overlap; Fasta hit to PTYA_ECOLI (147 aa), 40% identity in 124 aa overlap; Orthologue of E. coli yjhL (SGCA_ECOLI); Fasta hit to SGCA_ECOLI (143 aa), 72% identity in 142 aa overlap. (145 aa)
STY1450Putative phosphotransferase enzyme; Fasta hit to PTKC_ECOLI (451 aa), 42% identity in 431 aa overlap; Orthologue of E. coli yjhN (SGCC_ECOLI); Fasta hit to SGCC_ECOLI (437 aa), 95% identity in 437 aa overlap. (437 aa)
STY1451Putative phosphotransferase enzyme; Paralogue of E. coli gatB (PTKB_ECOLI); Fasta hit to PTKB_ECOLI (94 aa), 35% identity in 92 aa overlap. (93 aa)
STY1799Phosphoenolpyruvate dependent phosphotransferase enzyme III-cellobiose; Orthologue of E. coli celC (PTCA_ECOLI); Fasta hit to PTCA_ECOLI (116 aa), 87% identity in 115 aa overlap. (115 aa)
celBPTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
STY1801PTS system, cellobiose-specific IIB component; Orthologue of E. coli celA (PTCB_ECOLI); Fasta hit to PTCB_ECOLI (106 aa), 96% identity in 106 aa overlap. (106 aa)
manXSimilar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 96.0% id in 322 aa. (322 aa)
STY1960Phosphotransferase enzyme II, C component; Orthologue of E. coli manY (PTNC_ECOLI); Fasta hit to PTNC_ECOLI (266 aa), 94% identity in 266 aa overlap. (266 aa)
STY1961Phosphotransferase enzyme II, D component; Fasta hit to PTPD_ECOLI (263 aa), 35% identity in 274 aa overlap; Orthologue of E. coli manZ (PTND_ECOLI); Fasta hit to PTND_ECOLI (286 aa), 93% identity in 282 aa overlap. (283 aa)
STY2439PTS system, fructose-specific IIBC component; Fasta hit to PTVB_ECOLI (485 aa), 34% identity in 478 aa overlap; Orthologue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 94% identity in 507 aa overlap. (562 aa)
STY24411-phosphofructokinase; Fasta hit to K6P2_ECOLI (309 aa), 31% identity in 310 aa overlap; Orthologue of E. coli fruK (K1PF_ECOLI); Fasta hit to K1PF_ECOLI (312 aa), 98% identity in 312 aa overlap; Belongs to the carbohydrate kinase PfkB family. (312 aa)
STY2442Pts system, fructose-specific IIA/FPR component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
STY2572Putative membrane protein; Similar to Streptomyces coelicolor putative integral membrane protein SCJ21.17C TR:Q9S1Z0 (EMBL:AL109747) (516 aa) fasta scores: E(): 0, 47.3% id in 457 aa and Escherichia coli putative transport protein SgaT sgaT SW:SGAT_ECOLI (P39301) (484 aa) fasta scores: E(): 0, 27.6% id in 460 aa. Contains hydrophobic, probable membrane-spanning regions. (463 aa)
STY2573Similar to Escherichia coli unknown pentitol phosphotransferase enzyme II, B component sgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.0058, 28.7% id in 87 aa, and to the C-termini of pts system proteins e.g. Escherichia coli pts system, mannitol cmtA SW:PTYC_ECOLI (P32059) (462 aa) fasta scores: E(): 0.061, 30.9% id in 81 aa. (90 aa)
STY2574Putative sugar phosphotransferase component II A; Fasta hit to PTYA_ECOLI (147 aa), 41% identity in 146 aa overlap; Paralogue of E. coli ptxA (PTXA_ECOLI); Fasta hit to PTXA_ECOLI (154 aa), 40% identity in 140 aa overlap. (147 aa)
STY2667Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
STY2670Pts system, glucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. (169 aa)
STY2816Putative PTS system IIBC component; Similar to Bacillus subtilis negative regulatory protein of SacY sacX or sacS SW:SACX_BACSU (P15400) (459 aa) fasta scores: E(): 0, 33.1% id in 472 aa and putative PTS components e.g. Bacillus halodurans putative PTS system, sucrose phosphotransferase enzyme II BC component BH3574 TR:Q9K700 (EMBL:AP001519) (453 aa) fasta scores: E(): 0, 47.4% id in 454 aa; Orthologue of E. coli P77272; Fasta hit to P77272 (474 aa), 39% identity in 470 aa overlap. (453 aa)
STY2953PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlA (PTHC_ECOLI); Fasta hit to PTHC_ECOLI (187 aa), 97% identity in 187 aa overlap. (187 aa)
STY2954PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlE (PTHB_ECOLI); Fasta hit to PTHB_ECOLI (319 aa), 93% identity in 323 aa overlap. (323 aa)
STY2955PTS system, glucitol/sorbitol-specific IIA component; Orthologue of E. coli srlB (PTHA_ECOLI); Fasta hit to PTHA_ECOLI (123 aa), 81% identity in 118 aa overlap. (120 aa)
STY3144Phosphoenolpyruvate-protein phosphotransferase; Orthologue of E. coli ptsP (PT1P_ECOLI); Fasta hit to PT1P_ECOLI (748 aa), 95% identity in 748 aa overlap; Belongs to the PEP-utilizing enzyme family. (748 aa)
STY3437Similar to Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (485 aa) fasta scores: E(): 0, 32.4% id in 475 aa. Note, like the example given, the predicted product of this CDS contains only one hydrophilic IIB domain. Contains possible membrane spanning hydrophobic domains; Fasta hit to PTVB_ECOLI (485 aa), 32% identity in 474 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 42% identity in 471 aa overlap. (475 aa)
STY3438This CDS is similar to the phosphotransferase enzyme IIA and HPr (phosphoryl carrier protein) domains of PTF family sugar transport proteins, e.g. the N-terminus of Xanthomonas campestris multiphosphoryl transfer protein FruB SW:PTF1_XANCP (P45597) (837 aa) fasta scores: E(): 2.9e-22, 36.0% id in 225 aa; Paralogue of E. coli fruB (PTFA_ECOLI); Fasta hit to PTFA_ECOLI (376 aa), 36% identity in 372 aa overlap. (268 aa)
STY3441PTS system, galactitol-specific IIA component; Orthologue of E. coli gatA (PTKA_ECOLI); Fasta hit to PTKA_ECOLI (150 aa), 63% identity in 150 aa overlap. (154 aa)
STY3442PTS system, galactitol-specific IIB component; Orthologue of E. coli gatB (PTKB_ECOLI); Fasta hit to PTKB_ECOLI (94 aa), 79% identity in 94 aa overlap. (94 aa)
STY3443PTS system, galactitol-specific IIC component; Fasta hit to SGCC_ECOLI (437 aa), 43% identity in 432 aa overlap; Orthologue of E. coli gatC (PTKC_ECOLI); Fasta hit to PTKC_ECOLI (451 aa), 85% identity in 446 aa overlap. Contains possible membrane spanning hydrophobic domains. (457 aa)
ptsNSimilar to Escherichia coli nitrogen regulatory IIA protein PtsN or RpoP SW:PTSN_ECOLI (P31222) (163 aa) fasta scores: E(): 0, 95.1% id in 163 aa. (163 aa)
STY3503Phosphocarrier protein (nitrogen related hpr); Fasta hit to PTHP_ECOLI (85 aa), 30% identity in 79 aa overlap; Orthologue of E. coli ptsO (PTSO_ECOLI); Fasta hit to PTSO_ECOLI (90 aa), 97% identity in 90 aa overlap. (90 aa)
STY3925Similar to Escherichia coli PTS system, fructose-specific IIBC component SW:PTFB_ECOLI () (563 aa) fasta scores: E(): 0, 65.5% id in 458 aa. Note the product of this CDS lacks the first of the two E. coli EIIB transferase domains; Fasta hit to PTVB_ECOLI (485 aa), 35% identity in 450 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 66% identity in 458 aa overlap. (457 aa)
STY3999Similar to Escherichia coli PTS system, galactitol-specific IIB component SW:PTKB_ECOLI () (94 aa) fasta scores: E(): 2.9e-09, 37.2% id in 94 aa. (95 aa)
STY4000Putative PTS system IIC component; Similar to Bacillus halodurans PTS system galactitol-specific enzyme IIC component gatC TR:Q9Z9U2 (EMBL:AB011837) (419 aa) fasta scores: E(): 0, 45.0% id in 422 aa, and to Escherichia coli PTS system, galactitol-specific IIC component SW:PTKC_ECOLI () (451 aa) fasta scores: E(): 0, 39.7% id in 443 aa; Fasta hit to SGCC_ECOLI (437 aa), 37% identity in 430 aa overlap. (452 aa)
STY4004Similar to Mycoplasma capricolum phosphocarrier protein ptsH SW:PTHP_MYCCA (P45611) (88 aa) fasta scores: E(): 3.3e-06, 32.9% id in 76 aa, and to Alcaligenes eutrophus phosphocarrier protein SW:PTHP_ALCEU (P23537) (89 aa) fasta scores: E(): 7.5e-06, 33.7% id in 89 aa. (89 aa)
STY4013Similar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0.0015, 35.0% id in 123 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIAB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 0.0035, 25.2% id in 103 aa. (141 aa)
STY4014Similar to Bacillus subtilis PTS system, fructose-specific IIB component SW:PTFB_BACSU (P26380) (163 aa) fasta scores: E(): 6.6e-15, 30.2% id in 159 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 1.6e-14, 31.8% id in 157 aa, and to Escherichia coli PTS system, mannose-specific IIAB component manX or ptsl or gptB SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 3.5e-13, 29.9% id in 157 aa. (161 aa)
STY4015Putative PTS system protein; Orthologue of E. coli agaC (PTPC_ECOLI); Fasta hit to PTPC_ECOLI (267 aa), 30% identity in 238 aa overlap. (249 aa)
STY4016Similar to Escherichia coli PTS system, mannose-specific IID component SW:PTND_ECOLI (P08188) (286 aa) fasta scores: E(): 0, 39.9% id in 273 aa, and to Klebsiella pneumoniae PTS system, sorbose-specific IID component sorM SW:PTRD_KLEPN (P37083) (274 aa) fasta scores: E(): 3.2e-29, 34.8% id in 276 aa. (285 aa)
STY4111Mannitol-specific enzyme II of phosphotransferase system; Orthologue of E. coli mtlA (PTMA_ECOLI); Fasta hit to PTMA_ECOLI (637 aa), 96% identity in 637 aa overlap. (638 aa)
sgaTPutative transport protein SgaT; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (476 aa)
sgaBPutative PTS system IIB protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (101 aa)
sgaAProbable sugar phosphotransferase; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa)
treBSimilar to Escherichia coli pts system, trehalose-specific IIBC component treB SW:PTTB_ECOLI (P36672) (473 aa) fasta scores: E(): 0, 89.0% id in 472 aa and to Bacillus subtilis probable pts system, trehalose-specific IIBC component TreP treP or treB SW:PTTB_BACSU (P39794) (470 aa) fasta scores: E(): 0, 41.0% id in 463 aa. (472 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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