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STY0052 STY0052 STY0239 STY0239 rpmE2 rpmE2 STY0513 STY0513 STY0981 STY0981 STY1230 STY1230 STY1775 STY1775 STY1776 STY1776 STY2461 STY2461 STY2860 STY2860 STY2863 STY2863 STY3388 STY3388 STY3464 STY3464 STY3482 STY3482 STY3483 STY3483 STY3524 STY3524 STY3525 STY3525 STY3733 STY3733 STY3734 STY3734 STY3735 STY3735 STY3736 STY3736 STY3774 STY3774 rpmH rpmH STY4066 STY4066 STY4067 STY4067 rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ rpsF rpsF rpsR rpsR rplI rplI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STY005230S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
STY023930S ribosomal protein S2; Orthologue of E. coli rpsB (RS2_ECOLI); Fasta hit to RS2_ECOLI (240 aa), 98% identity in 240 aa overlap; Belongs to the universal ribosomal protein uS2 family. (241 aa)
rpmE2Putative 50s ribosomal protein L31 (second copy); Similar to Escherichia coli hypothetical 9.9 kDa protein in intf-eaeh intergenic region ykgM SW:YKGM_ECOLI (P71302) (87 aa) fasta scores: E(): 1.6e-27, 74.4% id in 86 aa, and to Listeria monocytogenes 50s ribosomal protein l31 rpmE SW:RL31_LISMO (Q9ZH28) (81 aa) fasta scores: E(): 7.9e-12, 48.1% id in 79 aa, and to Borrelia burgdorferi 50s ribosomal protein l31 rpme or bb0229 SW:RL31_BORBU (O51247) (81 aa) fasta scores: E(): 7.8e-11, 43.6% id in 78 aa; Fasta hit to RL31_ECOLI (70 aa), 33% identity in 84 aa overlap; Orthologue of E. coli [...] (86 aa)
STY0513Similar to Guillardia theta chloroplast 50s ribosomal protein l36 rpl36 SW:RK36_GUITH (P28528; O46911) (48 aa) fasta scores: E(): 1.6e-09, 56.5% id in 46 aa, and to Rickettsia prowazekii 50s ribosomal protein l36 rpmj or rp456 SW:RL36_RICPR (Q9ZD87) (41 aa) fasta scores: E(): 4.9e-08, 56.1% id in 41 aa. (46 aa)
STY098130S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (557 aa)
STY123050S ribosomal protein L32; Orthologue of E. coli rpmF (RL32_ECOLI); Fasta hit to RL32_ECOLI (56 aa), 100% identity in 56 aa overlap; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
STY177550S ribosomal subunit protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (118 aa)
STY177650S ribosomal subunit protein L35; Orthologue of E. coli rpmI (RL35_ECOLI); Fasta hit to RL35_ECOLI (64 aa), 100% identity in 64 aa overlap; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
STY246150s ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (94 aa)
STY286050S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
STY286330S ribosomal subunit protein S16; In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity. (82 aa)
STY338830S ribosomal subunit protein S21; Orthologue of E. coli rpsU (RS21_ECOLI); Fasta hit to RS21_ECOLI (70 aa), 100% identity in 70 aa overlap; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
STY346430S ribosomal subunit protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
STY348250S ribosomal subunit protein L27; Orthologue of E. coli rpmA (RL27_ECOLI); Fasta hit to RL27_ECOLI (84 aa), 95% identity in 84 aa overlap; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
STY348350S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
STY352430S ribosomal subunit protein S9; Orthologue of E. coli rpsI (RS9_ECOLI); Fasta hit to RS9_ECOLI (129 aa), 99% identity in 129 aa overlap; Belongs to the universal ribosomal protein uS9 family. (130 aa)
STY352550S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
STY373350S ribosomal subunit protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. (121 aa)
STY373450S ribosomal subunit protein L10; Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA (By similarity); Belongs to the universal ribosomal protein uL10 family. (165 aa)
STY373550S ribosomal subunit protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (234 aa)
STY373650S ribosomal subunit protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
STY377450S ribosomal protein L31; Binds the 23S rRNA. (70 aa)
rpmHSimilar to Escherichia coli 50s ribosomal protein l34 RpmH SW:RL34_ECOLI (P02437) (46 aa) fasta scores: E(): 1.5e-19, 100.0% id in 46 aa; Belongs to the bacterial ribosomal protein bL34 family. (46 aa)
STY406650S ribosomal subunit protein L28; Orthologue of E. coli rpmB (RL28_ECOLI); Fasta hit to RL28_ECOLI (77 aa), 96% identity in 77 aa overlap; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
STY406750S ribosomal subunit protein L33; Orthologue of E. coli rpmG (RL33_ECOLI); Fasta hit to RL33_ECOLI (54 aa), 100% identity in 54 aa overlap; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
rpsL30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy. (124 aa)
rpsG30S ribosomal subunit protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJ30S ribosomal subunit protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplC50S ribosomal subunit protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa)
rplD50S ribosomal subunit protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. Forms part of the polypeptide exit tunnel. Belongs to the universal ribosomal protein uL4 family. (201 aa)
rplW50S ribosomal subunit protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplB50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rpsS30S ribosomal subunit protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplV50S ribosomal subunit protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa)
rpsC30S ribosomal subunit protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity). Belongs to the universal ribosomal protein uS3 family. (233 aa)
rplP50S ribosomal subunit protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpmC50S ribosomal subunit protein L29; Orthologue of E. coli rpmC (RL29_ECOLI); Fasta hit to RL29_ECOLI (63 aa), 98% identity in 63 aa overlap; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rpsQ30S ribosomal subunit protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rplN50S ribosomal subunit protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rplX50S ribosomal subunit protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa)
rplE50S ribosomal subunit protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsN30S ribosomal subunit protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpsH30S ribosomal subunit protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rplF50S ribosomal subunit protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rplR50S ribosomal subunit protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rpsE30S ribosomal subunit protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (167 aa)
rpmD50S ribosomal subunit protein L30; Orthologue of E. coli rpmD (RL30_ECOLI); Fasta hit to RL30_ECOLI (58 aa), 97% identity in 58 aa overlap. (59 aa)
rplO50S ribosomal subunit protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmJ50S ribosomal subunit protein L36; Orthologue of E. coli rpmJ (RL36_ECOLI); Fasta hit to RL36_ECOLI (38 aa), 100% identity in 38 aa overlap; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsM30S ribosomal subunit protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa)
rpsK30S ribosomal subunit protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsD30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rplQ50S ribosomal subunit protein L17; Orthologue of E. coli rplQ (RL17_ECOLI); Fasta hit to RL17_ECOLI (127 aa), 99% identity in 127 aa overlap. (127 aa)
rpsF30s ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (131 aa)
rpsR30s ribosomal subunit protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplI50s ribosomal subunit protein L9; Binds to the 23S rRNA. (149 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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