STRINGSTRING
STY0254 STY0254 STY0285 STY0285 STY0463 STY0463 STY0528 STY0528 STY0697 STY0697 STY1014 STY1014 STY1240 STY1240 STY2082 STY2082 STY2084 STY2084 STY2276 STY2276 STY2663 STY2663 STY2753 STY2753 STY3033 STY3033 STY3148 STY3148 STY3198 STY3198 STY3608 STY3608 STY3667 STY3667 STY3941 STY3941 dam dam ssb ssb ssB ssB STY4636 STY4636 mutL mutL holC holC holD holD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0254DNA polymerase III, alpha chain; Orthologue of E. coli dnaE (DP3A_ECOLI); Fasta hit to DP3A_ECOLI (1160 aa), 97% identity in 1160 aa overlap. (1160 aa)
STY0285DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'- 5' exonuclease (By similarity). (243 aa)
STY0463Exodeoxyribonuclease small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
STY0528DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (642 aa)
STY0697DNA polymerase III, delta subunit; Orthologue of E. coli holA (HOLA_ECOLI); Fasta hit to HOLA_ECOLI (343 aa), 90% identity in 343 aa overlap. (343 aa)
STY1014Putative DNA methylase; Paralogue of E. coli dam (DMA_ECOLI); Fasta hit to DMA_ECOLI (278 aa), 46% identity in 266 aa overlap. (293 aa)
STY1240DNA polymerase III, delta' subunit; Orthologue of E. coli holB (HOLB_ECOLI); Fasta hit to HOLB_ECOLI (334 aa), 79% identity in 334 aa overlap. (334 aa)
STY2082DNA polymerase III, theta subunit; Orthologue of E. coli holE (HOLE_ECOLI); Fasta hit to HOLE_ECOLI (76 aa), 88% identity in 76 aa overlap. (76 aa)
STY2084Orthologue of E. coli EXOX_ECOLI; Fasta hit to EXOX_ECOLI (220 aa), 91% identity in 219 aa overlap. (232 aa)
STY2276Orthologue of E. coli sbcB (EX1_ECOLI); Fasta hit to EX1_ECOLI (475 aa), 93% identity in 468 aa overlap. (476 aa)
STY2663DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa)
STY2753Exodeoxyribonuclease large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (449 aa)
STY3033DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity). (855 aa)
STY3148DNA mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (231 aa)
STY3198Single-stranded DNA-specific exonuclease; Orthologue of E. coli recJ (RECJ_ECOLI); Fasta hit to RECJ_ECOLI (577 aa), 91% identity in 577 aa overlap. (577 aa)
STY3608DNA helicase II; Fasta hit to REP_ECOLI (673 aa), 38% identity in 666 aa overlap; Orthologue of E. coli uvrD (UVRD_ECOLI); Fasta hit to UVRD_ECOLI (720 aa), 98% identity in 720 aa overlap. (720 aa)
STY3667DNA adenine methylase; Highly similar to several including: Escherichia coli retron Ec67 DNA adenine methylase SW:DMA7_ECOLI (P21311) (285 aa) fasta scores: E(): 0, 97.5% id in 284 aa and to Serratia marcescens DNA adenine methylase Dam SW:DMA_SERMA (P45454) (270 aa) fasta scores: E(): 0, 47.2% id in 265 aa; Paralogue of E. coli dam (DMA_ECOLI); Fasta hit to DMA_ECOLI (278 aa), 47% identity in 263 aa overlap. (285 aa)
STY3941DNA polymerase III beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
damDNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. (278 aa)
ssbSingle-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (176 aa)
ssBPreviously sequenced Salmonella typhi single strand binding protein ssB TR:Q9RHF4 (EMBL:AF000001) (178 aa) fasta scores: E(): 0, 100.0% id in 178 aa. Also highly similar to other single-stranded DNA-binding proteins including: Escherichia coli SW:SSB_ECOLI () (177 aa) fasta scores: E(): 0, 71.8% id in 177 aa and Bacteriophage P1 single-stranded DNA-binding protein Ssb-p1 ssb-p1 TR:Q9XJG4 (EMBL:AF125376) (162 aa) fasta scores: E(): 0, 67.7% id in 164 aa. (178 aa)
STY4636DNA adenine methylase; Similar to Escherichia coli retron Ec67 DNA adenine methylase SW:DMA7_ECOLI (P21311) (285 aa) fasta scores: E(): 0, 82.7% id in 284 aa, and to Serratia marcescens DNA adenine methylase Dam SW:DMA_SERMA (P45454) (270 aa) fasta scores: E(): 0, 45.8% id in 262 aa. (286 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (618 aa)
holCSimilar to Escherichia coli DNA polymerase III, chi subunit HolC SW:HOLC_ECOLI (P28905) (147 aa) fasta scores: E(): 0, 95.2% id in 147 aa and to Haemophilus influenzae DNA polymerase III, chi subunit HolC SW:HOLC_HAEIN (P43749) (144 aa) fasta scores: E(): 1.4e-26, 48.6% id in 142 aa. (160 aa)
holDDNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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