STRINGSTRING
repA-2 repA-2 repB repB carB carB carA carA dut dut tmk tmk lp_0848 lp_0848 gmk2 gmk2 guaA guaA xpt xpt purK2 purK2 lp_1289 lp_1289 lp_1290 lp_1290 ribB ribB ribA ribA ribH ribH mltG mltG udk udk folD folD gmk1 gmk1 fhs fhs pyrR2 pyrR2 pyrAA2 pyrAA2 pyrAB2 pyrAB2 dfrA dfrA thyA thyA apt apt comEB comEB folC1 folC1 pyrP pyrP upp upp glyA glyA lp_2376 lp_2376 prmC prmC prfA prfA tdk tdk lp_2380 lp_2380 lp_2382 lp_2382 oroP oroP pyrE pyrE pyrF pyrF pyrD pyrD pyrAB pyrAB pyrAA pyrAA pyrC pyrC pyrB pyrB pyrR1 pyrR1 lp_2710 lp_2710 lp_2712 lp_2712 purD purD purH purH purN purN purM purM purF purF purL purL purQ purQ purS purS purC purC purK1 purK1 purE purE guaB guaB lp_3251 lp_3251 purB purB purA purA guaC guaC folP folP folQ folQ folC2 folC2 folE folE folK folK folB folB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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repA-2Copy-number control protein. (52 aa)
repBReplication protein. (219 aa)
carBCarbamoyl-phosphate synthase, large subunit. (1020 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (355 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (178 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (221 aa)
lp_0848Purine transport protein. (435 aa)
gmk2Guanylate kinase. (193 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (518 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (195 aa)
purK2Phosphoribosylaminoimidazole carboxylase,ATPase subunit; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (389 aa)
lp_1289Purine/pyrimidine phosphoribosyltransferase. (180 aa)
lp_1290Purine/pyrimidine permease. (357 aa)
ribBRiboflavin synthase, alpha chain. (139 aa)
ribA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. (404 aa)
ribHRiboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (159 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (401 aa)
udkUridine kinase. (209 aa)
folDBifunctional protein: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
gmk1Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
fhsFormate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (551 aa)
pyrR2Pyrimidine operon regulator; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (174 aa)
pyrAA2Carbamoyl-phosphate synthase (glutamine-hydrolysing), small chain; Belongs to the CarA family. (360 aa)
pyrAB2Carbamoyl-phosphate synthase (glutamine-hydrolysing), large chain; Belongs to the CarB family. (853 aa)
dfrADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (316 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
comEBComE operon protein 1, dCMP deaminase. (161 aa)
folC1formylTHF-polyglutamate synthase / folyl-polyglutamate synthase / hydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (444 aa)
pyrPUracil transport protein. (426 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
lp_2376Translation factor, SUA5 family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (339 aa)
prmCS-adenosyl-L-methionine-dependent N(5)-glutamine methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (288 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (360 aa)
tdkThymidine kinase. (192 aa)
lp_2380UDP-N-acetylmuramyl tripeptide synthase. (448 aa)
lp_2382Glutamine amidotransferase, CobQ-like domain. (240 aa)
oroPOrotate transport protein. (369 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (305 aa)
pyrABCarbamoyl-phosphate synthase,pyrimidine-specific, large chain. (1058 aa)
pyrAACarbamoyl-phosphate synthase,pyrimidine-specific, small chain; Belongs to the CarA family. (364 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
pyrR1Pyrimidine operon regulator; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (180 aa)
lp_2710Xanthine permease. (446 aa)
lp_2712Xanthine/uracil permease. (427 aa)
purDPhosphoribosylamine-glycine ligase. (413 aa)
purHBifunctional protein: phosphoribosylaminoimidazolecarboxamide formyltransferase; Unknown EC_number=2.1.2.3. (510 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (484 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (739 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase,PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is though [...] (84 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (243 aa)
purK1Phosphoribosylaminoimidazole carboxylase,ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purEPhosphoribosylaminoimidazole carboxylase,catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
guaBInosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (383 aa)
lp_32513',5'-cyclic-nucleotide phosphodiesterase. (284 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa)
folPDihydropteroate synthase. (382 aa)
folQDihydroneopterin triphosphate pyrophosphohydrolase. (195 aa)
folC2Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (454 aa)
folEGTP cyclohydrolase I. (189 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. (170 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa)
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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