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pyrF pyrF pyrE pyrE guaA guaA pyrH pyrH ctsR ctsR clpC clpC hrcA hrcA purB purB purM purM purN purN purH purH purD purD infB infB carB carB pyrG pyrG htrA htrA pyrR1 pyrR1 pyrB pyrB pyrD pyrD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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Your Input:
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (518 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa)
ctsRTranscription repressor of class III stress genes; Binds to the ftsH promoter region, leading to repression of its expression. (155 aa)
clpCATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (837 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (347 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa)
purHBifunctional protein: phosphoribosylaminoimidazolecarboxamide formyltransferase; Unknown EC_number=2.1.2.3. (510 aa)
purDPhosphoribosylamine-glycine ligase. (413 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (858 aa)
carBCarbamoyl-phosphate synthase, large subunit. (1020 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
htrASerine protease HtrA. (420 aa)
pyrR1Pyrimidine operon regulator; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (180 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (305 aa)
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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