STRINGSTRING
OB0035 OB0035 OB0084 OB0084 OB0086 OB0086 OB0226 OB0226 OB0230 OB0230 OB0430 OB0430 OB0465 OB0465 OB0497 OB0497 OB0519 OB0519 OB0521 OB0521 OB0522 OB0522 OB0524 OB0524 OB0547 OB0547 OB0549 OB0549 OB0550 OB0550 OB0614 OB0614 OB0680 OB0680 OB0681 OB0681 OB0740 OB0740 OB0741 OB0741 OB0938 OB0938 OB0971 OB0971 OB1097 OB1097 OB1107 OB1107 cysK cysK metC metC OB1132 OB1132 hemE hemE hemH hemH OB1191 OB1191 OB1343 OB1343 pyrF pyrF OB1504 OB1504 OB1518 OB1518 OB1519 OB1519 OB1656 OB1656 OB1657 OB1657 hemD hemD citB citB OB1703 OB1703 dapA dapA OB1710 OB1710 nth nth panD panD OB1767 OB1767 aroB aroB aroF aroF lysA lysA OB1927 OB1927 OB1928 OB1928 dra dra OB2005 OB2005 pheA pheA hemB hemB OB2067 OB2067 mutM mutM OB2176 OB2176 OB2214 OB2214 OB2215 OB2215 OB2220 OB2220 aroG aroG OB2267 OB2267 OB2268 OB2268 OB2284 OB2284 pckA pckA OB2323 OB2323 OB2404 OB2404 OB2420 OB2420 eno eno OB2523 OB2523 OB2616 OB2616 leuD leuD leuC leuC ilvD ilvD OB2686 OB2686 OB2687 OB2687 OB2697 OB2697 OB2703 OB2703 OB2741 OB2741 OB2751 OB2751 OB2803 OB2803 OB2804 OB2804 OB2806 OB2806 OB2836 OB2836 OB2841 OB2841 OB2843 OB2843 OB2845 OB2845 OB2867 OB2867 OB2883 OB2883 OB2946 OB2946 OB2949 OB2949 OB2965 OB2965 OB3004 OB3004 OB3005 OB3005 OB3046 OB3046 argH argH OB3203 OB3203 OB3214 OB3214 OB3218 OB3218 OB3230 OB3230 aroC aroC OB3245 OB3245 OB3254 OB3254 OB3351 OB3351 OB3382 OB3382 OB3399 OB3399 OB3411 OB3411
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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OB0035Lysine decarboxylase; CDS_ID OB0035. (472 aa)
OB0084Cysteine synthase A; CDS_ID OB0084; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
OB0086Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)
OB0226Mevalonate diphosphate decarboxylase; CDS_ID OB0226. (324 aa)
OB0230Hypothetical conserved protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (273 aa)
OB04303-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (257 aa)
OB0465Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
OB0497Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (278 aa)
OB0519Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (128 aa)
OB0521Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
OB0522Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
OB0524Indole-3-glycerol phosphate synthase; CDS_ID OB0524; Belongs to the TrpC family. (261 aa)
OB0547Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
OB0549Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
OB0550Imidazoleglycerol-phosphate dehydratase; CDS_ID OB0550. (194 aa)
OB0614Glucokinase regulatory protein-related protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (294 aa)
OB0680Unknown conserved protein (divided with OB0680 and OB0681); CDS_ID OB0680; Belongs to the ComB family. (90 aa)
OB0681Unknown conserved protein (divided with OB0680 and OB0681); CDS_ID OB0681; Belongs to the ComB family. (156 aa)
OB0740Phosphoribosylaminoimidazole carboxylase II; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (377 aa)
OB0741Adenylosuccinate lyase; CDS_ID OB0741; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
OB0938Hypothetical conserved protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (126 aa)
OB0971Phosphonate metabolism protein; CDS_ID OB0971. (289 aa)
OB1097Carbonic anhydrase; CDS_ID OB1097. (186 aa)
OB1107Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (153 aa)
cysKCysteine synthase; CDS_ID OB1108. (309 aa)
metCCystathionine beta-lyase; CDS_ID OB1109. (377 aa)
OB1132Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (345 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (312 aa)
OB1191Hypothetical conserved protein; CDS_ID OB1191. (87 aa)
OB1343hydroxymethylglutaryl-CoA lyase; CDS_ID OB1343. (300 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
OB1504Pantothenate metabolism (flavoprotein); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa)
OB1518L-serine dehydratase beta subunit; CDS_ID OB1518; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa)
OB1519L-serine dehydratase alpha subunit; CDS_ID OB1519; Belongs to the iron-sulfur dependent L-serine dehydratase family. (291 aa)
OB1656Hypothetical conserved protein; CDS_ID OB1656. (248 aa)
OB1657uroporphyrin-III C-methyltransferase (siroheme synthase); CDS_ID OB1657. (209 aa)
hemDuroporphyrinogen-III synthase; CDS_ID OB1658. (268 aa)
citBAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
OB1703Cysteine synthase; CDS_ID OB1703; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
OB1710Hypothetical conserved protein; CDS_ID OB1710. (392 aa)
nthEndonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
OB1767Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (140 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa)
aroFChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa)
lysADiaminopimelate decarboxylase (dap decarboxylase); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (435 aa)
OB1927Hypothetical protein; CDS_ID OB1927. (113 aa)
OB1928Hypothetical conserved protein; CDS_ID OB1928. (59 aa)
draDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa)
OB2005Hypothetical conserved protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (372 aa)
pheAPrephenate dehydratase; CDS_ID OB2041. (284 aa)
hemBPorphobilinogen synthase (delta-aminolevulinic acid dehydratase); CDS_ID OB2066; Belongs to the ALAD family. (328 aa)
OB2067uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (252 aa)
mutMformamidopyrimidine-DNA glycosidase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (280 aa)
OB2176Malate dehydrogenase (malic enzyme); CDS_ID OB2176. (411 aa)
OB22142-dehydro-3-deoxyphosphogluconate aldolase; CDS_ID OB2214. (210 aa)
OB2215Unknown conserved protein (partial); CDS_ID OB2215. (382 aa)
OB2220Hypothetical conserved protein; CDS_ID OB2220. (156 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase : chorismate mutase; CDS_ID OB2227. (357 aa)
OB2267Carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (301 aa)
OB2268Hypothetical conserved protein; CDS_ID OB2268. (478 aa)
OB2284Spore photoproduct lyase; CDS_ID OB2284. (357 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa)
OB2323Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (272 aa)
OB2404Isocitrate lyase; CDS_ID OB2404. (428 aa)
OB2420Spore coat polysaccharide synthesis (dTDP-glucose 4,6-dehydratase) (EC 4.2.1.46); CDS_ID OB2420; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (345 aa)
enoEnolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
OB2523Hypothetical protein; CDS_ID OB2523. (163 aa)
OB2616Threonine dehydratase (partial); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (338 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (192 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
ilvDDihydroxy-acid dehydratase; CDS_ID OB2624; Belongs to the IlvD/Edd family. (561 aa)
OB2686Amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (191 aa)
OB2687Superoxide-inducible protein 7(SOI7); Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa)
OB2697D-arabino 3-hexulose 6-phosphate formaldehyde lyase; CDS_ID OB2697. (181 aa)
OB27032-keto-3-deoxy-6-phospho-gluconate aldolase; CDS_ID OB2703. (210 aa)
OB2741Hypothetical conserved protein; CDS_ID OB2741. (135 aa)
OB2751Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
OB2803Coenzyme PQQ synthesis; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (240 aa)
OB28046-pyruvoyl tetrahydrobiopterin synthase; CDS_ID OB2804. (147 aa)
OB28063-hexulose-6-phosphate synthase; CDS_ID OB2806. (210 aa)
OB2836Glucarate dehydratase; CDS_ID OB2836. (454 aa)
OB28415-dehydro-4-deoxyglucarate dehydratase; CDS_ID OB2841; Belongs to the DapA family. (308 aa)
OB2843Muconate cycloisomerase; Catalyzes the regioselective dehydration of galactarate into 2-keto-D-threo-4,5-dihydroxyadipate ((2S,3R)-dihydroxy-5- oxohexanedioate). Is not active on other acid sugars. (391 aa)
OB2845Dihydrodipicolinate synthase; CDS_ID OB2845; Belongs to the DapA family. (304 aa)
OB2867Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa)
OB2883Nucleotide sugar epimerase; CDS_ID OB2883. (340 aa)
OB2946Hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
OB2949Cystathionine gamma-synthase; CDS_ID OB2949. (401 aa)
OB2965Muconate cycloisomerase; CDS_ID OB2965. (368 aa)
OB3004Transaldolase (pentose phosphate); Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (213 aa)
OB3005Fructose-bisphosphate aldolase; CDS_ID OB3005. (284 aa)
OB3046Methionine gamma-lyase; CDS_ID OB3046. (392 aa)
argHArgininosuccinate lyase; CDS_ID OB3128. (459 aa)
OB3203Hypothetical protein; CDS_ID OB3203. (246 aa)
OB32143, 4-dihydroxy-2-butanone 4-phosphate synthase (EC 5.4.99.-) (partial) (riboflavin biosynthesis); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (207 aa)
OB3218Malate oxidoreductase (NAD) (malic enzyme); CDS_ID OB3218. (396 aa)
OB3230hydroxymethylglutaryl-CoA lyase; CDS_ID OB3230. (318 aa)
aroC3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa)
OB3245Fructose-bisphosphate aldolase; CDS_ID OB3245; Belongs to the class I fructose-bisphosphate aldolase family. (294 aa)
OB3254L-fuculose-phosphate aldolase; CDS_ID OB3254. (214 aa)
OB3351Hypothetical conserved protein; CDS_ID OB3351. (228 aa)
OB3382Hypothetical conserved protein; CDS_ID OB3382; Belongs to the D-glutamate cyclase family. (252 aa)
OB3399Hypothetical conserved protein; CDS_ID OB3399. (392 aa)
OB3411D-mannonate dehydrolase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (349 aa)
Your Current Organism:
Oceanobacillus iheyensis
NCBI taxonomy Id: 221109
Other names: O. iheyensis HTE831, Oceanobacillus iheyensis HTE831, Oceanobacillus iheyensis str. HTE831, Oceanobacillus iheyensis strain HTE831, marine firmicute HTE831
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