STRINGSTRING
AAO53646.1 AAO53646.1 AAO53742.1 AAO53742.1 gcvT-1 gcvT-1 gcvH-1 gcvH-1 glnA-1 glnA-1 AAO53938.1 AAO53938.1 AAO53939.1 AAO53939.1 AAO53940.1 AAO53940.1 AAO53941.1 AAO53941.1 etfA-1 etfA-1 etfB-1 etfB-1 AAO53945.1 AAO53945.1 AAO53946.1 AAO53946.1 AAO53954.1 AAO53954.1 folA folA fdhA-1 fdhA-1 purU-1 purU-1 soxG-1 soxG-1 soxA-1 soxA-1 soxD-1 soxD-1 soxB-1 soxB-1 glyA-1 glyA-1 AAO54506.1 AAO54506.1 murI murI AAO54664.1 AAO54664.1 AAO54710.1 AAO54710.1 gcvT-2 gcvT-2 gcvP gcvP gcvH-2 gcvH-2 amiE amiE AAO54975.1 AAO54975.1 purT purT adhC adhC AAO55079.1 AAO55079.1 AAO55360.1 AAO55360.1 AAO55407.1 AAO55407.1 gabT-3 gabT-3 AAO55410.1 AAO55410.1 AAO55439.1 AAO55439.1 gltX gltX nasA nasA AAO55816.1 AAO55816.1 AAO55818.1 AAO55818.1 nasT nasT AAO55821.1 AAO55821.1 AAO55822.1 AAO55822.1 AAO55936.1 AAO55936.1 soxG-2 soxG-2 soxA-2 soxA-2 soxD-2 soxD-2 soxB-2 soxB-2 folD-1 folD-1 purU-2 purU-2 glsA glsA fdhA-2 fdhA-2 AAO56196.1 AAO56196.1 AAO56464.1 AAO56464.1 AAO56551.1 AAO56551.1 AAO56553.1 AAO56553.1 AAO56554.1 AAO56554.1 AAO56555.1 AAO56555.1 AAO56556.1 AAO56556.1 AAO56685.1 AAO56685.1 nirB nirB nirD nirD folD-2 folD-2 AAO57226.1 AAO57226.1 folC folC fmdA fmdA purU-3 purU-3 glyA-2 glyA-2 gltD gltD gltB gltB thyA thyA AAO58734.1 AAO58734.1 AAO58735.1 AAO58735.1 AAO58736.1 AAO58736.1 AAO58817.1 AAO58817.1 rubB rubB rubA rubA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AAO53646.1Aldehyde dehydrogenase family protein; Similar to SP:P23883, GB:M11147, GB:M10119, GB:M12938, GB:X03742, GB:X03743, SP:P02792, PID:1340145, PID:1340146, PID:182514, PID:182516, PID:182518, PID:2230869, and PID:28519; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P23883, GB:M11147, GB:M10119, GB:M12938, GB:X03742, GB:X03743, SP:P02792, PID:1340145, PID:1340146, PID:182514, PID:182516, PID:182518, PID:2230869, and PID:28519, identified by sequence similarity, putative; Belongs to the aldehyde dehydrogenase family. (497 aa)
AAO53742.1Nitrilase, putative; Similar to GP:15143035, and SP:Q03217; identified by sequence similarity; putative. (347 aa)
gcvT-1Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
gcvH-1Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
glnA-1Glutamine synthetase, type I; Identified by match to TIGR protein family HMM TIGR01692; see PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01692. (468 aa)
AAO53938.1Renal dipeptidase family protein. (325 aa)
AAO53939.1Conserved hypothetical protein; Identified by Glimmer2; putative. (176 aa)
AAO53940.1NADH:flavin oxidoreductase/NADH oxidase family protein. (686 aa)
AAO53941.1Iron-sulfur cluster-binding protein. (669 aa)
etfA-1Electron transfer flavoprotein, alpha subunit. (328 aa)
etfB-1Electron transfer flavoprotein, beta subunit. (265 aa)
AAO53945.1Iron-sulfur cluster-binding protein, Rieske family; Identified by match to PFAM protein family HMM PF00848. (410 aa)
AAO53946.1Iron-sulfur cluster-binding protein; Similar to GP:15073802; identified by sequence similarity; putative. (366 aa)
AAO53954.1Threonine aldolase, low-specificity; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (170 aa)
fdhA-1Glutathione-independent formaldehyde dehydrogenase; See PMID:20190049 for expression data; similar to SP:P46154, GB:X64318, GB:U26173, GB:S79880, PID:1237118, and PID:30956; identified by sequence similarity; putative. (399 aa)
purU-1Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
soxG-1Sarcosine oxidase, gamma subunit; Similar to SP:Q46338, GB:U11053, GB:U17298, GB:L36130, SP:P41145, PID:532060, PID:595933, PID:596070, PID:598185, and PID:722618; identified by sequence similarity; putative. (210 aa)
soxA-1Sarcosine oxidase, alpha subunit; Similar to SP:Q46337; identified by sequence similarity; putative; Belongs to the GcvT family. (1006 aa)
soxD-1Sarcosine oxidase, delta subunit; Similar to SP:Q46336, GB:U11053, GB:U17298, GB:L36130, SP:P41145, PID:532060, PID:595933, PID:596070, PID:598185, and PID:722618; identified by sequence similarity; putative. (98 aa)
soxB-1Sarcosine oxidase, beta subunit; Similar to GP:14023472, and SP:P40875; identified by sequence similarity; putative. (416 aa)
glyA-1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
AAO54506.1Iron-sulfur cluster-binding protein, Rieske family; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00355. (110 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (275 aa)
AAO54664.1Homocysteine S-methyltransferase family protein; See PMID:20190049 for expression data. (298 aa)
AAO54710.1Oxidoreductase, short chain dehydrogenase/reductase family; See PMID:20190049 for expression data; similar to GB:X68505, GB:X68505, GB:X63381, GB:X63381, SP:Q02078, SP:Q02080, PID:1197538, PID:34536, and PID:432656; identified by sequence similarity; putative. (236 aa)
gcvT-2Glycine cleavage system T protein; See PMID:20190049 for expression data. (409 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
amiEAliphatic amidase; Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. (338 aa)
AAO54975.1Conserved hypothetical protein; Identified by match to PFAM protein family HMM PF01244. (329 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
adhCAlcohol dehydrogenase, class III; See PMID:20190049 for expression data. (370 aa)
AAO55079.1Esterase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa)
AAO55360.1Threonine aldolase, low-specificity; See PMID:20190049 for expression data; similar to SP:P75823; identified by sequence similarity; putative. (334 aa)
AAO55407.1Conserved hypothetical protein; Similar to GP:15979446, and GP:15979446; identified by sequence similarity; putative. (461 aa)
gabT-34-aminobutyrate aminotransferase; Similar to SP:P22256; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
AAO55410.1Conserved hypothetical protein; Similar to GP:15157750; identified by sequence similarity; putative. (429 aa)
AAO55439.1Glutamine synthetase; Identified by match to TIGR protein family HMM TIGR00653; Belongs to the glutamine synthetase family. (447 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (493 aa)
nasANitrate reductase; Similar to GP:15159397, and SP:Q06457; identified by sequence similarity; putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (908 aa)
AAO55816.1Assimilatory nitrate reductase electron transfer subunit domain protein; Similar to GP:15159393, and SP:P42435; identified by sequence similarity; putative. (409 aa)
AAO55818.1Nitrate transporter. (403 aa)
nasTResponse regulator NasT. (191 aa)
AAO55821.1Conserved hypothetical protein. (403 aa)
AAO55822.1Hypothetical protein; Identified by Glimmer2; putative. (65 aa)
AAO55936.1Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. (364 aa)
soxG-2Sarcosine oxidase, gamma subunit; Similar to SP:Q46338; identified by sequence similarity; putative. (190 aa)
soxA-2Sarcosine oxidase, alpha subunit; Similar to SP:Q46337; identified by sequence similarity; putative; Belongs to the GcvT family. (968 aa)
soxD-2Sarcosine oxidase, delta subunit; Similar to GP:13241963, and SP:Q46336; identified by sequence similarity; putative. (101 aa)
soxB-2Sarcosine oxidase, beta subunit; Similar to SP:P40875; identified by sequence similarity; putative. (413 aa)
folD-1Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
glsAGlutaminase, putative; Similar to SP:P77470, SP:P37828, and PID:901847; identified by sequence similarity; putative; Belongs to the glutaminase family. (302 aa)
fdhA-2Glutathione-independent formaldehyde dehydrogenase; Similar to SP:P46154; identified by sequence similarity; putative. (379 aa)
AAO56196.1Conserved hypothetical protein; Similar to SP:P37906; identified by sequence similarity; putative. (427 aa)
AAO56464.1Oxidoreductase, 2-nitropropane dioxygenase family; Similar to GP:17430775; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to GP:17430775, identified by sequence similarity, putative. (359 aa)
AAO56551.1Iron-sulfur cluster-binding protein, rieske family; Similar to GP:15155696; identified by sequence similarity; putative. (416 aa)
AAO56553.1Aldehyde dehydrogenase family protein; Similar to SP:P23883; identified by sequence similarity; putative; Belongs to the aldehyde dehydrogenase family. (505 aa)
AAO56554.1Conserved hypothetical protein; Identified by Glimmer2; putative. (448 aa)
AAO56555.1Membrane protein; Similar to GP:15073108; identified by sequence similarity; putative. (194 aa)
AAO56556.1Hypothetical protein; Identified by Glimmer2; putative. (230 aa)
AAO56685.1Oxidoreductase, 2-nitropropane dioxygenase family; Identified by match to PFAM protein family HMM PF03060. (323 aa)
nirBNitrite reductase [NAD(P)H], large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (853 aa)
nirDNitrite reductase [NAD(P)H], small subunit. (128 aa)
folD-2Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
AAO57226.1Conserved protein of unknown function; Identified by match to PFAM protein family HMM PF02812; see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF02812. (1618 aa)
folCFolylpolyglutamate synthase/dihydrofolate synthase; Similar to GP:146009, and SP:P08192; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to GP:146009, and SP:P0819, identified by sequence similarity, putative; Belongs to the folylpolyglutamate synthase family. (434 aa)
fmdAFormamidase; Similar to GP:4774513, and SP:Q50228; identified by sequence similarity; putative. (410 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
gltDGlutamate synthase, small subunit; See PMID:20190049 for expression data. (472 aa)
gltBGlutamate synthase, large subunit; See PMID:20190049 for expression data. (1481 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa)
AAO58734.1Aminotransferase, class III; See PMID:20190049 for expression data; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
AAO58735.1Glutamine synthetase; See PMID:20190049 for expression data; Belongs to the glutamine synthetase family. (452 aa)
AAO58736.1Glutamine synthetase; See PMID:20190049 for expression data; Belongs to the glutamine synthetase family. (458 aa)
AAO58817.1Aminotransferase, class III; Similar to GP:15140985; identified by sequence similarity; putative. (970 aa)
rubBRubredoxin reductase; See PMID:20190049 for expression data; Belongs to the FAD-dependent oxidoreductase family. (382 aa)
rubARubredoxin; See PMID:20190049 for expression data. (55 aa)
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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