STRINGSTRING
phoD phoD yddT yddT ydhF ydhF phoB phoB ygxB ygxB phoA phoA cgeD cgeD phy phy pstBB pstBB pstBA pstBA pstA pstA pstC pstC pstS pstS phoR phoR phoP phoP yusU yusU yvyE yvyE yvhJ yvhJ tagO tagO tuaH tuaH tuaG tuaG tuaF tuaF tuaE tuaE tuaD tuaD tuaC tuaC tuaB tuaB mnaA mnaA ggaB ggaB ggaA ggaA tagH tagH tagG tagG tagF tagF tagE tagE tagD tagD tagA tagA tagB tagB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoDAlkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. (583 aa)
yddTPutative phage protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. (228 aa)
ydhFPutative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. (236 aa)
phoBAlkaline phosphatase III; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. (462 aa)
ygxBPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (552 aa)
phoAAlkaline phosphatase A; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. (461 aa)
cgeDProtein involved in maturation of the outermost layer of the spore; May be involved in maturation of the outermost layer of the spore. (426 aa)
phyPhytase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (382 aa)
pstBBPhosphate ABC transporter (ATP-binding protein); Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (260 aa)
pstBAPhosphate ABC transporter (ATP-binding protein); Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (269 aa)
pstAPhosphate ABC transporter (permease); Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (294 aa)
pstCPhosphate ABC transporter (permease); Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (309 aa)
pstSPhosphate ABC transporter (binding lipoprotein); Part of the ABC transporter complex PstSACB involved in phosphate import. (300 aa)
phoRTwo-component sensor histidine kinase; Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. (579 aa)
phoPTwo-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. (240 aa)
yusUConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (95 aa)
yvyEPutative translation regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the IMPACT family. (217 aa)
yvhJPutative membrane bound transcriptional regulator; May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG). Belongs to the LytR/CpsA/Psr (LCP) family. (391 aa)
tagOUDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase; Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to the peptidoglycan of B.subtilis; may also be involved in teichuronic acid biosynthesis (Probable); Belongs to the glycosyltransferase 4 family. (358 aa)
tuaHPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (397 aa)
tuaGPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (252 aa)
tuaFPutative hydrolase involved in teichuronic acid synthesis; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (226 aa)
tuaEPutative polymerase of teichuronic acid repeating units; Might be involved in the polymerization of teichuronic acid repeating units after their translocation to the outer surface of the membrane. (488 aa)
tuaDUDP-glucose 6-dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (461 aa)
tuaCPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (389 aa)
tuaBPutative exporter involved in biosynthesis of teichuronic acid; Might be involved in the translocation of teichuronic acid repeating units from the inner to the outer surface of the membrane. (483 aa)
mnaAUDP-N-acetylmannosamine 2-epimerase; Catalyzes the conversion of UDP-N-acetylglucosamine into UDP- N-acetylmannosamine, a precursor of the teichoic acid linkage unit. (380 aa)
ggaBPutative teichoic acid translocation permease protein tagG (fragment); Involved in the biosynthesis of galactosamine-containing minor teichoic acid, a non-essential cell wall polymer in B.subtilis 168; Belongs to the glycosyltransferase 2 family. (900 aa)
ggaAPoly(glucosyl N-acetylgalactosamine 1-phosphate) glucosyltransferase; Involved in the biosynthesis of galactosamine-containing minor teichoic acid, a non-essential cell wall polymer in B.subtilis 168; Belongs to the glycosyltransferase 2 family. (446 aa)
tagHTeichoic acids export ATP-binding protein TagH; Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system. (527 aa)
tagGTeichoic acid precursors permease; Part of the ABC transporter complex TagGH (TC 3.A.1.34.1) involved in exporting the two types of intracellularly synthesized teichoic acids. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. (275 aa)
tagFTeichoic acid poly(glycerol phosphate) polymerase; Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit. Synthesizes polymers of approximately 35 glycerol phosphate units in length. (746 aa)
tagEUDP-glucose:polyglycerol phosphate alpha-glucosyltransferase; Catalyzes the addition of glucose to the C-2 hydroxy group of the glycerol units in teichoic acid. (673 aa)
tagDGlycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the cytidylyl group of CTP to sn- glycerol 3-phosphate so the activated glycerol 3-phosphate can be used for teichoic acid synthesis, via incorporation into both the linkage unit and the teichoic acid polymer by TagB and TagF. Belongs to the cytidylyltransferase family. (129 aa)
tagAN-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily. (256 aa)
tagBTeichoic acid glycerol-phosphate primase; Catalyzes the addition of a single glycerol phosphate residue to the prenoldiphosphate-linked disaccharide, as a primer for polymerisation by TagF; Belongs to the CDP-glycerol glycerophosphotransferase family. (381 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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