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| | nasF | uroporphyrin-III C-methyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the precorrin methyltransferase family. (483 aa) |
| | rimI | Ribosomal protein S18 alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (151 aa) |
| | hmoA | Heme-degrading monooxygenase; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron; Belongs to the antibiotic biosynthesis monooxygenase family. (108 aa) |
| | yfiQ | Putative membrane component involved in biofilm formation; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (362 aa) |
| | yfhH | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (104 aa) |
| | gsaB | Glutamate-1-semialdehyde aminotransferase, class III aminotransferase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (429 aa) |
| | ygzB | Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (117 aa) |
| | ygaN | Putative sulfur-related oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (178 aa) |
| | hemZ | Coproporphyrinogen III oxidase; Involved in the biosynthesis of porphyrin-containing compound; Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemZ subfamily. (501 aa) |
| | yhaR | Putative dehydratase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (255 aa) |
| | yhaA | Putative amidohydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (396 aa) |
| | yhfA | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa) |
| | yhgB | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (104 aa) |
| | hmoB | Heme-degrading monooxygenase; Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron; Belongs to the antibiotic biosynthesis monooxygenase family. (166 aa) |
| | hemE | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (353 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family. (310 aa) |
| | hemY | Protoporphyrinogen IX and coproporphyrinogen III oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III. (470 aa) |
| | yjcF | Putative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (140 aa) |
| | yjcG | Putative RNA ligase or phosphoesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (171 aa) |
| | yjcH | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (240 aa) |
| | ctaO | Minor protoheme IX farnesyltransferase 1 (heme O synthase); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (329 aa) |
| | yjjA | Putative enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (270 aa) |
| | ykkB | Putative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (172 aa) |
| | ylaH | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (105 aa) |
| | ylaL | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (161 aa) |
| | ctaA | heme-A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group. Also involved in the sporulation. (306 aa) |
| | ctaB | Protoheme IX farnesyltransferase 2; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (305 aa) |
| | ctaC | Cytochrome caa3 oxidase (subunit II); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (356 aa) |
| | ctaD | Cytochrome caa3 oxidase (subunit I); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. (622 aa) |
| | ctaE | Cytochrome caa3 oxidase (subunit III); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the cytochrome c oxidase subunit 3 family. (207 aa) |
| | ctaF | Cytochrome caa3 oxidase (subunit IV); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the cytochrome c oxidase bacterial subunit 4 family. (110 aa) |
| | ctaG | Cytochrome aa(3) assembly factor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (297 aa) |
| | ylbA | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (120 aa) |
| | ymfC | Putative transcriptional regulator (GntR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (241 aa) |
| | yneK | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (142 aa) |
| | yozB | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (178 aa) |
| | scuA | Assembly factor BSco of the Cu(A) site of cytochrome c oxidase; Necessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling; Belongs to the SCO1/2 family. (193 aa) |
| | ypzF | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (48 aa) |
| | ypbS | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (85 aa) |
| | dynA | Dynamin-like GTPase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (1193 aa) |
| | qcrC | Menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit); Component of the menaquinol-cytochrome c reductase complex. (255 aa) |
| | qcrB | Menaquinol:cytochrome c oxidoreductase (cytochrome b subunit); Component of the menaquinol-cytochrome c reductase complex. (224 aa) |
| | qcrA | Menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit); Component of the menaquinol-cytochrome c reductase complex. The Rieske protein is a high potential 2Fe-2S protein. (167 aa) |
| | ypiF | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (148 aa) |
| | resE | Two-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. (589 aa) |
| | resD | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa) |
| | resC | Factor required for cytochrome c synthesis; Required for the biogenesis of c-type cytochromes. (391 aa) |
| | resB | Factor required for cytochrome c synthesis; Required for the biogenesis of c-type cytochromes. (542 aa) |
| | resA | Extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein); Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation. Belongs to the thioredoxin family. ResA subfamily. (179 aa) |
| | yqzF | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (78 aa) |
| | yqgY | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (81 aa) |
| | cccA | Cytochrome c550; Not essential for growth on minimal or rich media. (120 aa) |
| | hemN | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine (By similarity). (379 aa) |
| | lepA | Ribosomal elongation factor, GTPase; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (612 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminotransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (430 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). (324 aa) |
| | hemD | Uroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. Belongs to the uroporphyrinogen-III synthase family. (262 aa) |
| | hemC | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (314 aa) |
| | hemX | Negative effector of the concentration of glutamyl-tRNA reductase HemA; Required for HemL synthesis; To M.leprae U1620K. (276 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (455 aa) |
| | ysxD | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (165 aa) |
| | acuA | Protein acetyltransferase; Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue. (210 aa) |
| | acuB | Component of the acetoin degradation regulation pathway; Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source. (214 aa) |
| | acuC | Protein deacetylase; Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source; Belongs to the histone deacetylase family. (387 aa) |
| | ytkA | Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein. (145 aa) |
| | yugN | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (134 aa) |
| | yugM | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (123 aa) |
| | kapD | Putative exoribonuclease (3'-5'); Specifically inhibits the KinA pathway to sporulation. (205 aa) |
| | yuxK | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the DCC thiol-disulfide oxidoreductase family. (137 aa) |
| | yuiB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (106 aa) |
| | yuiA | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (47 aa) |
| | yutF | Putative p-nitrophenyl phosphatase; Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro; Belongs to the HAD-like hydrolase superfamily. NagD family. (256 aa) |
| | yutE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0331 family. (144 aa) |
| | yutD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 12770717. (91 aa) |
| | yutC | Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein. (210 aa) |
| | cccB | Cytochrome c551; Electron carrier protein. (112 aa) |
| | ywpJ | Putative phosphatase; Catalyzes the dephosphorylation of phosphorylated 5-6 carbon sugars and monophosphate nucleotides (NMP) in vitro (By similarity). To a lesser extent, dephosphorylates flavin mononucleotide (FMN) in vitro. (285 aa) |
| | glcR | Transcriptional regulator (DeoR family); Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars. (258 aa) |
| | ywpG | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (127 aa) |
| | ywpF | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (136 aa) |
| | ywjG | Putative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (173 aa) |
| | ywhD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (172 aa) |
| | ywhC | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase M50B family. (219 aa) |
| | ywhB | 1,3-keto-enol tautomerase; Catalyzes both 1,3- and 1,5-keto-enol tautomerization of the diacid 2-hydroxymuconate (2-hydroxy-2,4-hexadienedioate) to produce 2- oxo-4-hexenedioate. This reaction is highly stereoselective and produces a mixture of stereoisomers, where the (3S)-isomer of 2-oxo-4- hexenedioate predominates. Also catalyzes the tautomerization of 2- hydroxymuconate to 2-oxo-3-hexenedioate, however this reaction is slower and occurs after the tautomerization of 2-hydroxymuconate to 2- oxo-4-hexenedioate. Using 2-hydroxy-2,4-pentadienoate, phenylenolpyruvate, (p-hydroxyphenyl)- [...] (62 aa) |
| | hemQ | Essential component of heme biosynthesis; May function as heme-dependent peroxidase. (254 aa) |
| | qoxD | Cytochrome aa3-600 quinol oxidase (subunit IV); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (124 aa) |
| | qoxC | Cytochrome aa3-600 quinol oxidase (subunit III); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (204 aa) |
| | qoxB | Cytochrome aa3-600 quinol oxidase (subunit I); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (649 aa) |
| | qoxA | Cytochrome aa3-600 quinol oxidase (subunit II); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I (By similarity). (321 aa) |
| | ywcB | Putative phage protein (superinfection immunity); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. (102 aa) |
| | ywcA | Putative acetate Na+-dependent symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (513 aa) |
| | yybF | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (404 aa) |
| | yybE | Putative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the LysR transcriptional regulatory family. (292 aa) |
| | yybD | Putative acetyltransferase; Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. (147 aa) |
| | yybC | Putative integral membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (159 aa) |
