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yfhH yfhH ygzB ygzB ygaN ygaN ctaO ctaO ylaL ylaL ctaA ctaA ctaB ctaB ctaC ctaC ctaD ctaD ctaE ctaE ctaF ctaF ctaG ctaG ylbA ylbA yozB yozB scuA scuA qcrC qcrC qcrB qcrB qcrA qcrA ypiF ypiF resE resE resD resD resC resC resB resB resA resA yqzF yqzF yqgY yqgY cccA cccA ytkA ytkA yuiB yuiB yuiA yuiA cccB cccB ywpF ywpF ywjG ywjG qoxD qoxD qoxC qoxC qoxB qoxB qoxA qoxA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yfhHConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (104 aa)
ygzBPutative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (117 aa)
ygaNPutative sulfur-related oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (178 aa)
ctaOMinor protoheme IX farnesyltransferase 1 (heme O synthase); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (329 aa)
ylaLConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (161 aa)
ctaAheme-A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group. Also involved in the sporulation. (306 aa)
ctaBProtoheme IX farnesyltransferase 2; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (305 aa)
ctaCCytochrome caa3 oxidase (subunit II); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (356 aa)
ctaDCytochrome caa3 oxidase (subunit I); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. (622 aa)
ctaECytochrome caa3 oxidase (subunit III); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the cytochrome c oxidase subunit 3 family. (207 aa)
ctaFCytochrome caa3 oxidase (subunit IV); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the cytochrome c oxidase bacterial subunit 4 family. (110 aa)
ctaGCytochrome aa(3) assembly factor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (297 aa)
ylbAConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (120 aa)
yozBPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (178 aa)
scuAAssembly factor BSco of the Cu(A) site of cytochrome c oxidase; Necessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling; Belongs to the SCO1/2 family. (193 aa)
qcrCMenaquinol:cytochrome c oxidoreductase (cytochrome cc subunit); Component of the menaquinol-cytochrome c reductase complex. (255 aa)
qcrBMenaquinol:cytochrome c oxidoreductase (cytochrome b subunit); Component of the menaquinol-cytochrome c reductase complex. (224 aa)
qcrAMenaquinol:cytochrome c oxidoreductase (iron-sulfur subunit); Component of the menaquinol-cytochrome c reductase complex. The Rieske protein is a high potential 2Fe-2S protein. (167 aa)
ypiFConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (148 aa)
resETwo-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. (589 aa)
resDTwo-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa)
resCFactor required for cytochrome c synthesis; Required for the biogenesis of c-type cytochromes. (391 aa)
resBFactor required for cytochrome c synthesis; Required for the biogenesis of c-type cytochromes. (542 aa)
resAExtracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein); Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation. Belongs to the thioredoxin family. ResA subfamily. (179 aa)
yqzFConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (78 aa)
yqgYConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (81 aa)
cccACytochrome c550; Not essential for growth on minimal or rich media. (120 aa)
ytkAPutative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein. (145 aa)
yuiBConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (106 aa)
yuiAConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (47 aa)
cccBCytochrome c551; Electron carrier protein. (112 aa)
ywpFConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (136 aa)
ywjGPutative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (173 aa)
qoxDCytochrome aa3-600 quinol oxidase (subunit IV); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (124 aa)
qoxCCytochrome aa3-600 quinol oxidase (subunit III); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (204 aa)
qoxBCytochrome aa3-600 quinol oxidase (subunit I); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity). (649 aa)
qoxACytochrome aa3-600 quinol oxidase (subunit II); Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I (By similarity). (321 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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