(27 nodes) Mixed, incl. Bacterial periplasmic substrate-binding proteins, and Amino acid ABC transporter, permease protein, 3-TM domain network (Bacillus subtilis 168)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	yckA	Putative ABC transporter (permease); Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. (226 aa)
	yckB	Putative ABC transporter (binding lipoprotein); Probably part of a binding-protein-dependent transport system; Belongs to the bacterial solute-binding protein 3 family. (287 aa)
	tcyC	Cystine ABC transporter (ATP-binding protein); Part of the ABC transporter complex TcyABC involved in L- cystine import. Responsible for energy coupling to the transport system (Probable). (247 aa)
	tcyB	Cystine ABC transporter (permease); Part of the ABC transporter complex TcyABC involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. (234 aa)
	tcyA	Cystine ABC transporter (substrate-binding lipoprotein); Part of the ABC transporter complex TcyABC involved in L- cystine import. (268 aa)
	ssuB	Aliphatic sulfonate ABC transporter (ATP-binding protein); Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable). Is also involved in taurine transport. (255 aa)
	ssuA	Aliphatic sulfonate ABC transporter (binding lipoprotein); Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein. (332 aa)
	ssuC	Aliphatic sulfonate ABC transporter (permease); Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane. (276 aa)
	ssuD	FMNH2-dependent aliphatic sulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. (376 aa)
	glnQ	Glutamine ABC transporter (ATP-binding protein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for energy coupling to the transport system (By similarity). (242 aa)
	glnH	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family. (273 aa)
	glnM	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. (216 aa)
	glnP	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. (218 aa)
	ytoI	Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (439 aa)
	ytnM	Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (300 aa)
	ytnL	Putative aminohydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase M20 family. (416 aa)
	rbfK	RNA-binding cryptic riboflavin kinase regulatory protein; May be directly involved in the regulation of the rib genes. C-terminal part of RibR specifically binds to RFN of the rib leader of the riboflavin biosynthetic operon. The RFN element is a sequence within the rib-leader mRNA reported to serve as a receptor for an FMN- dependent riboswitch. Possibly, RibR produces the comodulator FMN through its own N-terminal flavokinase activity. FMN-activated RibR may stabilize the anti-anti terminator structure of RFN mRNA, causing transcription termination of the rib genes in trans. (230 aa)
	ytnJ	Putative monooxygenase; May play a role in methionine degradation. May play a role in a sulfur salvage pathway. (442 aa)
	ytnI	Putative redoxin; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glutaredoxin family. (93 aa)
	ytmO	Putative monooxygenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To bacterial alkanal monooxygenase alpha and beta chains. (334 aa)
	tcyN	Sulfur-containing amino-acid ABC transporter (ATP-binding protein); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Responsible for energy coupling to the transport system (Probable). Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the ABC transporter superfamily. L-cystine importer (TC 3.A.1.3.13) family. (259 aa)
	tcyM	Sulfur-containing amino acid ABC transporter (permease); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport. (235 aa)
	tcyL	Sulfur-containing amino acid ABC transporter (permease); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport. (239 aa)
	tcyK	Sulfur-containing amino acid ABC transporter binding lipoprotein; Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the bacterial solute-binding protein 3 family. (270 aa)
	tcyJ	Sulfur containing amino acid ABC transporter binding lipoprotein; Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the bacterial solute-binding protein 3 family. (269 aa)
	ytmI	Putative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (178 aa)
	ytlI	Transcriptional regulator (LysR family); Positively regulates the expression of ytmI operon in response to the availability of sulfur sources. (308 aa)

Your Current Organism:

Bacillus subtilis 168

NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
glnH	glnM	BSU27440	BSU27450	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	0.999
glnH	glnP	BSU27440	BSU27460	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	0.999
glnH	glnQ	BSU27440	BSU27430	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Glutamine ABC transporter (ATP-binding protein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for energy coupling to the transport system (By similarity).	0.999
glnH	tcyB	BSU27440	BSU03600	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Cystine ABC transporter (permease); Part of the ABC transporter complex TcyABC involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family.	0.949
glnH	tcyC	BSU27440	BSU03590	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Cystine ABC transporter (ATP-binding protein); Part of the ABC transporter complex TcyABC involved in L- cystine import. Responsible for energy coupling to the transport system (Probable).	0.799
glnH	tcyK	BSU27440	BSU29370	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Sulfur-containing amino acid ABC transporter binding lipoprotein; Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the bacterial solute-binding protein 3 family.	0.474
glnH	tcyL	BSU27440	BSU29360	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Sulfur-containing amino acid ABC transporter (permease); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport.	0.906
glnH	tcyM	BSU27440	BSU29350	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Sulfur-containing amino acid ABC transporter (permease); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport.	0.877
glnH	tcyN	BSU27440	BSU29340	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Sulfur-containing amino-acid ABC transporter (ATP-binding protein); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Responsible for energy coupling to the transport system (Probable). Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the ABC transporter superfamily. L-cystine importer (TC 3.A.1.3.13) family.	0.770
glnH	yckA	BSU27440	BSU03370	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Putative ABC transporter (permease); Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.	0.964
glnH	yckB	BSU27440	BSU03380	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	Putative ABC transporter (binding lipoprotein); Probably part of a binding-protein-dependent transport system; Belongs to the bacterial solute-binding protein 3 family.	0.479
glnM	glnH	BSU27450	BSU27440	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Glutamine ABC transporter (glutamine-binding lipoprotein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport; Belongs to the bacterial solute-binding protein 3 family.	0.999
glnM	glnP	BSU27450	BSU27460	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	0.994
glnM	glnQ	BSU27450	BSU27430	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Glutamine ABC transporter (ATP-binding protein); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for energy coupling to the transport system (By similarity).	0.999
glnM	tcyA	BSU27450	BSU03610	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Cystine ABC transporter (substrate-binding lipoprotein); Part of the ABC transporter complex TcyABC involved in L- cystine import.	0.977
glnM	tcyB	BSU27450	BSU03600	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Cystine ABC transporter (permease); Part of the ABC transporter complex TcyABC involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family.	0.475
glnM	tcyC	BSU27450	BSU03590	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Cystine ABC transporter (ATP-binding protein); Part of the ABC transporter complex TcyABC involved in L- cystine import. Responsible for energy coupling to the transport system (Probable).	0.885
glnM	tcyJ	BSU27450	BSU29380	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Sulfur containing amino acid ABC transporter binding lipoprotein; Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the bacterial solute-binding protein 3 family.	0.799
glnM	tcyK	BSU27450	BSU29370	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Sulfur-containing amino acid ABC transporter binding lipoprotein; Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Is also involved in cystathionine, djenkolate, and S- methylcysteine transport; Belongs to the bacterial solute-binding protein 3 family.	0.753
glnM	tcyL	BSU27450	BSU29360	Glutamine ABC transporter (permease); Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family.	Sulfur-containing amino acid ABC transporter (permease); Part of the ABC transporter complex TcyJKLMN involved in L- cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport.	0.512

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