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| | salA | Mrp family regulator; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (352 aa) |
| | ybbP | Putative enzyme with DAC domain protein; One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di- AMP synthesis. Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis. In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess. (273 aa) |
| | ybbR | Conserved hypothetical protein; Upon coexpression in E.coli stimulates the diadenylate cyclase activity of CdaA about 20-fold. In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess. (483 aa) |
| | ndhF | Putative NADH dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the complex I subunit 5 family. (505 aa) |
| | ybcC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0753 family. (871 aa) |
| | ybcF | Putative carbonic anhydrase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the beta-class carbonic anhydrase family. (175 aa) |
| | ybcH | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (96 aa) |
| | ybcI | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (124 aa) |
| | ybeC | Putative H+/amino acid transporter; Uptake of an yet unknown amino-acid with the concomitant import of a proton; Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family. (539 aa) |
| | gltP | Proton/glutamate symport protein; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (414 aa) |
| | opuAA | Glycine betaine ABC transporter (ATP-binding protein); Involved in a multicomponent binding-protein-dependent transport system for glycine betaine. Probably responsible for energy coupling to the transport system. (418 aa) |
| | opuAB | Glycine betaine ABC transporter (permease); Involved in a multicomponent binding-protein-dependent transport system for glycine betaine; probably responsible for the translocation of the substrate across the membrane. (282 aa) |
| | opuAC | Glycine betaine ABC transporter (glycine betaine-binding lipoprotein); Involved in a multicomponent binding-protein-dependent transport system for glycine betaine. (293 aa) |
| | putB | Proline oxidase; Converts proline to delta-1-pyrroline-5-carboxylate. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (303 aa) |
| | putC | 1-pyrroline-5-carboxylate dehydrogenase; Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (515 aa) |
| | putP | Proline permease; Catalyzes the high-affinity uptake of extracellular proline. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (473 aa) |
| | putR | Transcriptional activator of proline degradation operon; Activates transcription of the putBCP operon. Requires proline as a coactivator. (411 aa) |
| | yclG | Putative uronase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (584 aa) |
| | ycsF | Putative nitrogen-containing heterocycle degradation enzyme; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Belongs to the LamB/PxpA family. (257 aa) |
| | ycsG | Putative branched chain amino acids transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (404 aa) |
| | ycsI | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 9334321; Belongs to the D-glutamate cyclase family. (257 aa) |
| | kipI | Putative inhibitor of the autophosphorylation reaction of KinA; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. In addition, is a potent inhibitor of the autophosphorylation reaction of kinase A (kinA) and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. Is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is non- competitive with re [...] (240 aa) |
| | kipA | Putative hydrolase subunit antagonist of KipI; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. In addition, counteracts the inhibitory action of PxpB (KipI) on sporulation, by binding to PxpB and preventing its function as an inhibitor of kinase A. (335 aa) |
| | kipR | Transcriptional regulator (IclR family); Transcriptional repressor of the kip gene-containing operon. (250 aa) |
| | lipC | Spore coat phospholipase B; Lipase involved in spore germination. Belongs to the 'GDSL' lipolytic enzyme family. (213 aa) |
| | yczI | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (81 aa) |
| | ydaB | Putative acyl-CoA ligase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the ATP-dependent AMP-binding enzyme family. (503 aa) |
| | ydaO | Putative metabolite transporter; High-affinity potassium transporter. (607 aa) |
| | ydeD | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (319 aa) |
| | fra | Frataxin; Possible global iron distributor for the cell. Promotes the biosynthesis of iron-sulfur clusters by delivering Fe to the iron- sulfur cluster assembly scaffold protein SufU. In the presence of SufS and L-cysteine reconstitutes Fe-S clusters on SufU, which when further incubated with apo-aconitase (citB) reconstitutes aconitase activity. Able to reconstitute an Fe-S cluster on Thermotoga maritima IscU. (123 aa) |
| | gabP | Gamma-aminobutyrate (GABA) permease; High-affinity uptake system for GABA. Functions also as a low-affinity proline importer; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (469 aa) |
| | ydzX | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (95 aa) |
| | yeaC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the MoxR family. (320 aa) |
| | yeaD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (398 aa) |
| | yebA | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (737 aa) |
| | yecA | Putative amino acid/polyamine permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (424 aa) |
| | opuE | Proline transporter; Catalyzes the uptake of extracellular proline under high- osmolarity growth conditions. Essential for the use of proline present in the environment as an osmoprotectant. (492 aa) |
| | yfnC | Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (409 aa) |
| | yfnB | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the HAD-like hydrolase superfamily. YjjG family. (235 aa) |
| | yfnA | Metabolite permease; Involved in import of methylthioribose (MTR) into the cell. (461 aa) |
| | yfmQ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (148 aa) |
| | yfkC | Putative mechanosensitive ion channel; May play a role in resistance to osmotic downshock. Belongs to the MscS (TC 1.A.23) family. (280 aa) |
| | yfkA | Putative Fe-S oxidoreductase, radical SAM superfamily; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (373 aa) |
| | yfjT | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (61 aa) |
| | yfiR | Transcriptional regulator (TetR/AcrR family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (205 aa) |
| | yfhJ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (89 aa) |
| | ygaE | Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (353 aa) |
| | bcaP | Branched-chain amino acid transporter; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (465 aa) |
| | yhdH | Putative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (451 aa) |
| | crcBA | Integral membrane protein possibly involved in chromosome condensation; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (118 aa) |
| | yhdV | Integral membrane protein possibly involved in chromosome condensation; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (131 aa) |
| | yhdX | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (35 aa) |
| | yhdY | Putative integral membrane protein; May play a role in resistance to osmotic downshock. (371 aa) |
| | nhaC | Na+/H+ antiporter; Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system. (453 aa) |
| | yhaJ | Putative bacteriocin; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (172 aa) |
| | yjcM | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (409 aa) |
| | yjcN | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (106 aa) |
| | yjiA | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (92 aa) |
| | ykbA | Putative amino acid permease; Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids. (438 aa) |
| | proG | Redundant pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (365 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | ykzB | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 10671441. (51 aa) |
| | ykoL | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 10671441. (60 aa) |
| | ykoM | Putative transcriptional regulator (MarR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (154 aa) |
| | ktrD | K+-transporting ATPase; Integral membrane subunit of the KtrCD potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress; Belongs to the TrkH potassium transport family. Ktr (TC 2.A.38.4) subfamily. (449 aa) |
| | ykuT | Putative small-conductance mechanosensitive channel; May play a role in resistance to osmotic downshock. Belongs to the MscS (TC 1.A.23) family. (267 aa) |
| | ktrC | Potassium uptake protein; Catalytic subunit of the KtrCD potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress. (221 aa) |
| | ynzL | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (41 aa) |
| | yneP | acyl-CoA thioesterase; Has acyl-CoA thioesterase activity. (121 aa) |
| | yneQ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (99 aa) |
| | yneT | Putative CoA-binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (135 aa) |
| | ynfC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (136 aa) |
| | alsT | Amino acid carrier protein; Evidence 2b: Function of strongly homologous gene; Product type t: transporter; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (465 aa) |
| | proJ | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa) |
| | proH | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (297 aa) |
| | yobO | Putative phage-related pre-neck appendage protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. (806 aa) |
| | yocR | Putative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (445 aa) |
| | yocS | Putative sodium-dependent transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (321 aa) |
| | yojJ | Putative enzyme with DAC domain; One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di- AMP synthesis. Overexpression of the hyperactive mutant (L44F) in the absence of c-di-AMP phosphodiesterase GdpP leads to growth defects in log phase (long curly cell filaments) that disappear upon sporulation; spore formation is normal, showing sporulation is insensitive to the excess c-di-AMP. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...] (207 aa) |
| | yoyD | Putative exported protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. (66 aa) |
| | yodF | Putative Na+/metabolite permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa) |
| | fer | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. This ferredoxin may act as a phosphodonor to cytochrome P450 BioI. (82 aa) |
| | proI | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (278 aa) |
| | yqfF | Putative membrane associate hydrolase; Probably has phosphodiesterase (PDE) activity against cyclic- di-AMP (c-di-AMP); may be the major c-di-AMP PDE in the cell. In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess. (711 aa) |
| | comER | Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase. (273 aa) |
| | yraH | Putative lyase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glyoxalase I family. (128 aa) |
| | yrbD | Sodium/proton-dependent alanine transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; transporter. (484 aa) |
| | braB | Branched-chain amino acid-Na+ symporter; Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force. (445 aa) |
| | opuD | Glycine betaine transporter; High-affinity uptake of glycine betaine. Does not mediate either carnitine or choline uptake; Belongs to the BCCT transporter (TC 2.A.15) family. (512 aa) |
| | ytnA | Putative amino acid permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa) |
| | gbsB | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine from choline; Belongs to the iron-containing alcohol dehydrogenase family. (402 aa) |
| | gbsA | Glycine betaine aldehyde dehydrogenase, NAD+-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine from choline. Catalyzes the oxidation of betaine aldehyde to betaine. Shows specificity for betaine aldehyde as substrate. Can use both NAD(+) and NADP(+), but NAD(+) is strongly preferred. (490 aa) |
| | yuaC | Putative transcriptional regulator; Negatively regulates the expression of the gbsAB and opuB operons. Required to control expression of these genes in response to choline availability. Also required to downregulate glycine betaine production once cellular adjustment to high osmolarity has been achieved; Belongs to the GbsR family. (180 aa) |
| | ktrA | Potassium uptake protein; Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress. (222 aa) |
| | ktrB | Potassium transporter ATPase; Integral membrane subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress. (445 aa) |
| | yugK | Putative NADH-dependent butanol dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (390 aa) |
| | yufS | Putative bacteriocin; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (71 aa) |
| | mrpA | Sodium transporter component of a Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs [...] (801 aa) |
| | mrpB | Na+/H+ antiporter complex; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporters (T [...] (143 aa) |
| | mrpC | Component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporte [...] (113 aa) |
| | mrpD | Proton transporter component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to [...] (493 aa) |
| | mrpE | Non essential component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the [...] (158 aa) |
| | mrpF | Efflux transporter for Na+ and cholate; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). (94 aa) |
| | mrpG | Non essential component of Na+/H+ antiporter; May enhance MrpA stability, assembly, or function. May play chaperone or assembly roles for MrpA and perhaps for other mrp proteins. (124 aa) |
| | yuiF | Amino acid transporter; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. (442 aa) |
| | yumC | ferredoxin-NADP+ reductase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the ferredoxin--NADP reductase type 2 family. (332 aa) |
| | yuzB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0349 family. (78 aa) |
| | putM | Proline dehydrogenase 1; Converts proline to delta-1-pyrroline-5-carboxylate. (302 aa) |
| | lysP | Lysine permease; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (469 aa) |
| | nhaK | Na+/H+ antiporter; Transporter involved in the efflux of sodium, potassium, lithium and rubidium. (670 aa) |
| | yvgT | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (202 aa) |
| | opuBD | Choline ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for choline; probably responsible for the translocation of the substrate across the membrane. (226 aa) |
| | opuBC | Choline ABC transporter (choline-binding lipoprotein); Member of a high affinity multicomponent binding-protein- dependent transport system for choline. (306 aa) |
| | opuBB | Choline ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for choline; probably responsible for the translocation of the substrate across the membrane. (217 aa) |
| | opuBA | Choline ABC transporter (ATP-binding protein); Involved in a high affinity multicomponent binding-protein- dependent transport system for choline. Probably responsible for energy coupling to the transport system. (381 aa) |
| | yvaV | Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the GbsR family. (177 aa) |
| | opuCD | Glycine betaine/carnitine/choline/choline sulfate ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa) |
| | opuCC | Glycine betaine/carnitine/choline-binding protein OpuCC; Member of a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine, and choline. Belongs to the OsmX family. (303 aa) |
| | opuCB | Glycine betaine/carnitine/choline/choline sulfate ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (217 aa) |
| | opuCA | Glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for energy coupling to the transport system. (380 aa) |
| | yvbF | Putative transcriptional regulator; Negatively regulates the transcription of the opuC operon. In the absence of GbsR, is also a negative regulator of the opuB operon. Binds to an inverted repeat in the promoter region of the operons. (185 aa) |
| | yvbW | Putative leucine permease; May participate in leucine metabolism. May transport leucine or a compound related to leucine metabolism; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (447 aa) |
| | yveA | L-aspartate/L-glutamate permease; Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency. (520 aa) |
| | yvdT | Putative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (194 aa) |
| | mscL | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell. (130 aa) |
| | ureC | Urease (alpha subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (569 aa) |
| | ureB | Urease (beta subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease beta subunit family. (124 aa) |
| | ureA | Urease (gamma subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the urease gamma subunit family. (105 aa) |
| | ywiB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (142 aa) |
| | rocC | Arginine/ornithine permease; Putative transport protein involved in arginine degradative pathway. Probably transports arginine or ornithine. (470 aa) |
| | rocB | Putative N-deacylase involved in arginine and ornithine utilization; Involved in arginine degradative pathway. (566 aa) |
| | yweA | Member of the processed secretome; Has a minor role in biofilm architecture. May contribute to the surface hydrophobicity. (154 aa) |
| | yxkD | Efflux transporter; Evidence 1a: Function experimentally demonstrated in the studied strain; transporter. (278 aa) |
| | hutP | Transcriptional antiterminator; Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization; Belongs to the HutP family. (148 aa) |
| | hutH | Histidine ammonia-lyase (histidase); Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (508 aa) |
| | hutU | Urocanase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate; Belongs to the urocanase family. (552 aa) |
| | hutI | Imidazolone-5-propionate hydrolase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (421 aa) |
| | hutG | Formiminoglutamate hydrolase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide. (319 aa) |
| | hutM | Histidine permease; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. (475 aa) |
| | argI | Arginase; Involved in the catabolism of arginine. Belongs to the arginase family. (296 aa) |
| | rocE | Arginine/ornithine/gamma-aminobutyrate permease; Putative transport protein involved in arginine degradative pathway. Probably transports arginine or ornithine. (467 aa) |
| | rocD | Ornithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. Controls arginine catabolism. (401 aa) |
| | rocR | Transcriptional regulator (NtrC/NifA family); Positive regulator of arginine catabolism. Controls the transcription of the two operons rocABC and rocDEF and probably acts by binding to the corresponding upstream activating sequences. (461 aa) |
| | cdnD | Phosphodiesterase acting on cyclic dinucleotides; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. Overexpression leads to increased sensitivity to methyl methanesulfonate (MMS) and H(2)O(2). Overexpression leads to extreme sensitivity to the beta-lactam antibiotic cefuroxime (CEF), probably dependent on PDE activity. May monitor cellular heme or NO levels. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...] (659 aa) |
