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| | yaaC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (315 aa) |
| | yaaH | Spore peptidoglycan hydrolase; N-acetylglucosaminidase involved in cortex peptidoglycan degradation during germination. Cleaves only partially degraded spore peptidoglycans. Recognizes muramic acid delta-lactam residues specific to spore peptidoglycans. (427 aa) |
| | bofA | Inhibitor of the pro-sigma(K) processing machinery; Involved in the mediation of the intercompartmental coupling of pro-sigma K processing to events in the forespore. Inhibits SpoIVFB- processing activity until a signal has been received from the forespore. Could inhibit SpoIVFB metalloprotease activity by coordinating a zinc in the SpoIVFB active site, preventing access of a water molecule and the sequence of pro-sigma K, which are necessary for peptide bond hydrolysis to produce sigma-K. (87 aa) |
| | csfB | Forespore-specific anti-sigma factor; An anti-sigma-G factor, prevents premature activation of sigma-G factor in the forespore; overexpression leads to 1000-fold reduction in spore formation, spore formation stops after engulfment. Overexpression also inhibits sigma- G transcription activation activity. When both Gin and sigma-G are expressed in E.coli Gin inhibits sigma-G, strongly suggesting Gin inhibits by direct physical interaction. (64 aa) |
| | sspF | Small acid-soluble spore protein (alpha/beta-type SASP); May play some important role in either sporulation or the dormant spore. (61 aa) |
| | spoVT | Transcriptional regulator; Transcriptional factor that regulates positively or negatively the expression of a large number of forespore-specific sigma G-dependent genes. May provide a mechanism of feedback control that is important for forespore development. SpoVT levels during spore formation have a major impact on the germination and the resistance of the resultant spores. To B.subtilis AbrB and Abh. (178 aa) |
| | yabP | Spore protein involved in the shaping of the spore coat; Required for sporulation. (100 aa) |
| | yabQ | Membrane protein of the forespore; Required for sporulation. Plays an important role in cortex and coat formation. (211 aa) |
| | spoIIE | SpoIIAA-phosphate serine phosphatase; Normally needed for pro-sigma E processing during sporulation but can be bypassed in vegetative cells. Activates SpoIIAA by dephosphorylation. (827 aa) |
| | yabS | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (245 aa) |
| | yabT | Putative serine/threonine-protein kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (338 aa) |
| | ybaK | Putative alkylated deoxynucleotide triphosphohydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (147 aa) |
| | cwlD | N-acetylmuramoyl-L-alanine amidase; Cleaves the peptide side chain from the N-acetylmuramic acid residues in peptidoglycan. This is a step in the formation of muramic delta-lactam residues in spore cortex. (237 aa) |
| | gerD | Lipoprotein with a role in spores' rapid response to nutrient germinants; May be involved in fructose recognition during germination. (185 aa) |
| | ybaN | Polysaccharide deacetylase involved in sporulation; Necessary to maintain spores after the late stage of sporulation. Might be involved in cortex formation. (254 aa) |
| | cwlJ | Cell wall hydrolase; Probable spore cortex-lytic enzyme involved in the depolymerization of cortex peptidoglycan during germination. (142 aa) |
| | ycgH | Putative amino acid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (446 aa) |
| | gerKA | Spore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the GerABKA family. (544 aa) |
| | gerKC | Spore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the GerABKC lipoprotein family. (407 aa) |
| | gerKB | Spore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (373 aa) |
| | glcU | Glucose uptake protein; Involved in the uptake of glucose. (287 aa) |
| | gdh | Glucose 1-dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa) |
| | ydcC | Putative lipoprotein; required for efficient sporulation. (338 aa) |
| | ydzR | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 19383706, 20709900; Belongs to the GerPA/GerPF family. (76 aa) |
| | ydfR | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (225 aa) |
| | ydfS | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (235 aa) |
| | ydhD | Spore cortex lytic enzyme; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type cp: cell process; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. (420 aa) |
| | yetF | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (231 aa) |
| | yfkT | Putative spore germination integral inner membrane protein; May be involved in spore germination. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (358 aa) |
| | yfkS | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (66 aa) |
| | yfkR | Putative spore germination protein; May be involved in spore germination. Belongs to the GerABKC lipoprotein family. (384 aa) |
| | yfkQ | Putative spore germination protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (513 aa) |
| | pdaA | Exported N-acetylmuramic acid deacetylase; Catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in glycan strands of peptidoglycan, leading to the formation of muramic delta-lactam residues in spore cortex, after transpeptidation of deacetylated muramic acid residues. PdaA probably carries out both deacetylation and lactam ring formation and requires the product of CwlD activity on peptidoglycan as a substrate. Is required for germination. Cannot use chitin oligomer (hexa-N- acetylchitohexaose) as a substrate; Belongs to the polysaccharide deacetylase family. (263 aa) |
| | sspH | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process; Belongs to the SspH family. (59 aa) |
| | yfhD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (63 aa) |
| | yfhE | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (36 aa) |
| | sspK | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process; Belongs to the SspK family. (50 aa) |
| | sspE | Small acid-soluble spore protein (gamma-type SASP); SASP are proteins degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. These proteins may be involved in dormant spore's high resistance to UV light. (84 aa) |
| | yhcM | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (151 aa) |
| | yhcN | Putative lipoprotein; Probably contributes, directly or indirectly, to early events in germination. May play a role in spore outgrowth. (189 aa) |
| | yhdB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (80 aa) |
| | yheN | Putative polysaccharide deacetylase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (282 aa) |
| | sspB | Small acid-soluble spore protein (beta-type SASP); SASP are bound to spore DNA. They are double-stranded DNA- binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light. (67 aa) |
| | yhaL | Sporulation factor; Required for efficient sporulation. (70 aa) |
| | yitF | Putative enolase superfamily enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (371 aa) |
| | yizC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (65 aa) |
| | yjaV | Putative NAD(P) binding enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (185 aa) |
| | yjbA | Putative nucleic acid binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor; Belongs to the UPF0736 family. (250 aa) |
| | sspD | Small acid-soluble spore protein (alpha/beta-type SASP); SASP are bound to spore DNA. They are double-stranded DNA- binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light. (64 aa) |
| | ykzP | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (51 aa) |
| | ykzE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (58 aa) |
| | ykvI | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (347 aa) |
| | ykvP | Spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (399 aa) |
| | ykzQ | Putative peptidoglycan binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. (75 aa) |
| | ykvQ | Putative sporulation-specific glycosylase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 18 family. (232 aa) |
| | ykzR | Putative spore-specific glycosyl hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 18 family. (83 aa) |
| | ykvT | Cell wall hydrolase related to spore cortex-lytic enzymes; Evidence 2b: Function of strongly homologous gene; enzyme. (208 aa) |
| | abh | Transcriptional regulator; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; To B.subtilis AbrB and SpoVT. (92 aa) |
| | ylaJ | Putative lipoprotein; Probably contributes, directly or indirectly, to early events in germination. (209 aa) |
| | ylbJ | Putative factor required for spore cortex formation; Required for spore cortex formation. (408 aa) |
| | gerR | DNA-binding regulator; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (193 aa) |
| | spoIIGA | Protease processing pro-sigma-E; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. (309 aa) |
| | sigE | RNA polymerase sporulation-specific sigma-29 factor (sigma-E); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. (239 aa) |
| | sigG | RNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes in the forespore. (260 aa) |
| | ylmC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 12429060. (81 aa) |
| | ylzA | Conserved hypothetical protein; Regulates the biosynthesis of the extracellular matrix and the biofilm formation. Activates the transcription of the matrix biosynthesis operons eps and tapA-sipW- tasA. Also activates expression of the opuA operon, involved in osmoprotection. Acts by binding specifically to the promoter region of the target genes. Acts in parallel to the pathway that governs SinR derepression. Required for endosporulation. (89 aa) |
| | spoVM | Factor required for normal spore cortex and coat synthesis (stage V sporulation); Coordinates cortex and coat assembly during sporulation. Associates with the spore coat protein SpoIVA and with the outer forespore membrane, thereby serving as a membrane anchor that tethers SpoIVA and the entire spore coat to the forespore surface. May also serve as a competitive inhibitor of FtsH activity during sporulation. (26 aa) |
| | ylxY | Putative sugar deacetylase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the polysaccharide deacetylase family. (319 aa) |
| | mlpA | Specific processing protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (409 aa) |
| | ymxH | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the YlmC/YmxH family. (85 aa) |
| | cotE | Morphogenic spore protein; Morphogenic protein required for the assembly of the outer coat of the endospore. Is also a regulatory protein for the expression of cotA, cotB, cotC, cotH and other genes encoding spore outer coat proteins. (181 aa) |
| | yndD | Putative spore germination protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (520 aa) |
| | yndE | Putative spore germination integral inner membrane protein; Involved in the germinative response to L-alanine. Could be an amino acid transporter (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (363 aa) |
| | yndF | Putative spore germination lipoprotein; May be involved in spore germination. Belongs to the GerABKC lipoprotein family. (404 aa) |
| | yndM | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (179 aa) |
| | sspP | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the SspP family. (48 aa) |
| | sspO | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the SspO family. (48 aa) |
| | sspN | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the SspN family. (48 aa) |
| | tlp | Small acid-soluble spore protein (thioredoxin-like protein); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the Tlp family. (83 aa) |
| | nrnB | Oligoribonuclease (nanoRNase); Degrades RNA oligonucleotides with a length of 5 nucleotides in a 3'- to 5'-direction. Less active on shorter RNA oligonucleotides and on those with a length of 24 nucleotides. Prefers RNA oligonucleotides containing adenines rather than cytosines. (399 aa) |
| | yozQ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (97 aa) |
| | yoyE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (41 aa) |
| | sspC | Small acid-soluble spore protein (alpha/beta-type SASP); SASP are bound to spore DNA. They are double-stranded DNA- binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light. (72 aa) |
| | sspL | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (42 aa) |
| | ypzG | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (50 aa) |
| | sspM | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (34 aa) |
| | ypjB | Spore formation membrane associated protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. (264 aa) |
| | ypjA | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (185 aa) |
| | spoIVA | Morphogenetic stage IV sporulation protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM. (492 aa) |
| | ypeB | Spore membrane component; Required for spore cortex hydrolysis during germination. Appears to be required for either expression, localization, activation or function of SleB. (450 aa) |
| | sleB | Spore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components. (305 aa) |
| | spoVAF | Stage V sporulation protein AF; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (493 aa) |
| | spoVAEA | Stage V sporulation germinant protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (203 aa) |
| | spoVAEB | Spore germinant protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (116 aa) |
| | spoVAD | Stage V sporulation protein AD; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (338 aa) |
| | spoVAC | Stage V sporulation protein AC; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (150 aa) |
| | spoVAB | Stage V sporulation protein AB; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (141 aa) |
| | spoVAA | Stage V sporulation protein AA; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (206 aa) |
| | sigF | RNA polymerase sporulation-specific sigma factor (sigma-F); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. Interaction with SpoIIAB inhibits sigma-F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. Responsible for expression of csfB (the anti-sigma-G factor Gin). (255 aa) |
| | spoIIAB | Anti-sigma factor (antagonist of sigma(F)) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa) |
| | spoIIAA | Anti-anti-sigma factor (antagonist of SpoIIAB); In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition; Belongs to the anti-sigma-factor antagonist family. (117 aa) |
| | spoIIM | Autolysin component for dissolution of the septal cell wall (stage II sporulation); Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane. (214 aa) |
| | bkdR | Transcriptional regulator; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (692 aa) |
| | spoIVB | Regulatory membrane-associated serine protease; Plays a central role in the sigma-K checkpoint which coordinates gene expression during the later stages of spore formation. The protease is activated by trans cleavage of the zymogen precursor producing SpoIVB-45 kDa. This undergoes further trimming by cis cleavage to form SpoIVB-43 kDa and SpoIVB-42 kDa. The protease then cleaves the C-terminus of the SpoIVFA metalloprotease activating the latter. (426 aa) |
| | spoIIIAH | Stage III sporulation ratchet engulfment protein; Involved in forespore engulfment. Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling. (218 aa) |
| | spoIIIAG | Stage III sporulation engulfment assembly protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (229 aa) |
| | spoIIIAF | Stage III sporulation protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (206 aa) |
| | spoIIIAE | Stage III sporulation protein; Required during sporulation for activation of sigma factor SpoIIIG/SigG after engulfment is completed in the prespore. Overexpression in the absence of SpoIIIJ is synthetically lethal. (399 aa) |
| | spoIIIAD | Stage III sporulation protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (133 aa) |
| | spoIIIAC | Stage III sporulation protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (68 aa) |
| | spoIIIAB | Stage III sporulation protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (171 aa) |
| | spoIIIAA | ATP-binding stage III sporulation protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (307 aa) |
| | yqhV | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (93 aa) |
| | yqhO | Conserved hypothetical protein; Probable lipid hydrolase. (291 aa) |
| | yqhH | Putative RNA polymerase-associated helicase protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the SNF2/RAD54 helicase family. (557 aa) |
| | yqhG | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (264 aa) |
| | yqfX | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (129 aa) |
| | yqfD | Stage IV sporulation protein; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type cp: cell process. (398 aa) |
| | yqfC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 12662922. (93 aa) |
| | spoIIP | Spore autolysin (stage II sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (401 aa) |
| | gpr | Spore endopeptidase; Initiates the degradation of small, acid-soluble proteins during spore germination. (368 aa) |
| | yraG | Putative spore coat protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (81 aa) |
| | yraF | Putative spore coat protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (122 aa) |
| | yraE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (65 aa) |
| | yraD | Putative spore coat protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (99 aa) |
| | yrzQ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (43 aa) |
| | yrzR | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (63 aa) |
| | yrrD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (174 aa) |
| | spoVB | Putative putative translocase with flippase function for teichoic acid synthesis; Involved, directly or indirectly, in spore cortex biosynthesis. Affects only indirectly the expression of late sporulation genes. (518 aa) |
| | yrbG | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (218 aa) |
| | yrzE | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (150 aa) |
| | safA | Morphogenetic protein associated with SpoVID; Probably involved in the assembly of some coat protein components implicated in both lysozyme resistance and germination. Could be required for the assembly of CotG. Associates with SpoIVD during the early stage of coat assembly. (387 aa) |
| | spoIVFB | Membrane metalloprotease; Implicated in the coupling of mother cell to forespore gene expression. Required for spore formation. Processes the pro-sigma K factor. (288 aa) |
| | spoIVFA | Regulator of SpoIVFB (stage IV sporulation); Implicated in the coupling of mother cell to forespore gene expression. Required for spore formation at 37 degrees Celsius, but not at 30 degrees Celsius. SpoIVFA plays a central role in both maintaining the SpoIVFA/BofA/SpoIVFB complex and anchoring it to the outer forespore membrane. SpoIVFA brings BofA into close proximity to SpoIVFB, allowing BofA to inhibit SpoIVFB. Increased accumulation of SpoIVFA seems to inhibit the activity of SpoIVFB and thus regulates the activation of sigma-K. (264 aa) |
| | spoIIB | Stage II sporulation protein B; Involved in endospore development. (332 aa) |
| | ysxE | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (341 aa) |
| | spoVID | Morphogenetic spore protein (stage VI sporulation); Required for assembly of a normal spore coat. May be a component of the innermost layer of the spore coat that aids in its adherence to the prespore. (575 aa) |
| | lonB | LonB ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity); Belongs to the peptidase S16 family. (552 aa) |
| | gerM | Germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme; Unknown. Affects both sporulation and germination. (366 aa) |
| | gerE | Transcriptional regulator; Involved in the regulation of spore formation. Directs the transcription of several genes that encode structural components of the protein coat that encases the mature spore (CotB, CotC, CotG, CotS, CotV, CotW, CotX, CotY and CotZ). Controls also the cgeAB and cgeCDE operons. (74 aa) |
| | sspI | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the SspI family. (71 aa) |
| | ytaF | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (210 aa) |
| | ytvI | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (371 aa) |
| | ytrH | Membrane protein involved in a sporulation process; Involved in sporulation. May contribute to cortex formation or stability. (113 aa) |
| | ytrI | Protein involved in sporulation; Involved in sporulation. (167 aa) |
| | nrnA | Oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 3-mers. Directionality is controversial; shown to degrade 5-mers and less in a 3' to 5' direction , and 11-mers in a 5' to 3' direction. Converts 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. (313 aa) |
| | ytfJ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (151 aa) |
| | ytfI | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (226 aa) |
| | sspA | Small acid-soluble spore protein (alpha-type SASP); SASP are bound to spore DNA. They are double-stranded DNA- binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light. (69 aa) |
| | ytzC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (90 aa) |
| | ytzL | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (52 aa) |
| | yteA | Putative DksA homolog; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (239 aa) |
| | yuzA | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (78 aa) |
| | yutH | Spore coat-associated protein; Involved in sporulation; Belongs to the CotS family. (339 aa) |
| | lytH | Sporulation-specific L-Ala-D-Glu endopeptidase; L-Ala--D-Glu endopeptidase involved in production of single L-alanine side chains from tetrapeptides in the spore cortex peptidoglycan. Therefore, is required for the endospore cortex maturation. (326 aa) |
| | yunB | Putative protein involved in spore formation; Required for sporulation. (254 aa) |
| | yunC | Putative RNA binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. (101 aa) |
| | yurZ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (125 aa) |
| | yuzM | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (81 aa) |
| | yusN | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (110 aa) |
| | gerAA | Component of the GerA germination receptor; Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of GerD and GerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (482 aa) |
| | gerAB | Component of the germination receptor GerA; Involved in the germinative response to L-alanine. Could be an amino acid transporter. Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (365 aa) |
| | gerAC | Component of the germination receptor GerA; Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of GerD and GerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (373 aa) |
| | sspJ | Small acid-soluble spore protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (46 aa) |
| | yvbX | Putative epimerase modification of peptidoglycan; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 18 family. (344 aa) |
| | yvdQ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (170 aa) |
| | ctpB | Swarming motility protein; Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro- sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the pre-processed regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation. Belongs to the peptidase S41A family. (480 aa) |
| | gerBA | Component of germinant receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors respectively). (483 aa) |
| | gerBB | Component of germinant receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Could be an amino acid transporter. Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors, respectively). (368 aa) |
| | gerBC | Lipoprotein component of the germination receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors respectively). (374 aa) |
| | spoIIID | Transcriptional regulator; This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K). (93 aa) |
| | spoIIQ | Forespore protein required for alternative engulfment; Involved in forespore engulfment and required for anchoring membrane proteins on the forespore side of the septal membrane. Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling. (283 aa) |
| | spoIID | Autolysin required for complete dissolution of the asymmetric septum (stage II sporulation); May act at the level of sigma-G activity or its stability. SpoIID is probably required for engulfment. (343 aa) |
| | spoIIR | pro-sigma(E) endopeptidase (stage II sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (224 aa) |
| | rsfA | Prespore-specific regulatory gene; Seems to improve the efficiency of sporulation by fine-tuning the expression of genes in the sigma F regulon, particularly the timing of their expression. Negatively regulates spoIIR and its own synthesis. (258 aa) |
| | gerQ | Inner spore coat protein; Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA. (181 aa) |
| | ywaF | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (237 aa) |
| | yxjB | Putative ribosomal RNA methyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the methyltransferase superfamily. RlmA family. (282 aa) |
| | nupG | Purine nucleoside transporter; Involved in the uptake of the purine ribonucleosides inosine and guanosine. (397 aa) |
| | yxeD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (117 aa) |
| | yyaC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (205 aa) |
