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spoVT spoVT spoIIGA spoIIGA sigE sigE sigG sigG spoVAF spoVAF spoVAEA spoVAEA spoVAEB spoVAEB spoVAD spoVAD spoVAC spoVAC spoVAB spoVAB spoVAA spoVAA sigF sigF spoIIAB spoIIAB spoIIAA spoIIAA gpr gpr spoIIID spoIIID spoIIR spoIIR yyaC yyaC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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spoVTTranscriptional regulator; Transcriptional factor that regulates positively or negatively the expression of a large number of forespore-specific sigma G-dependent genes. May provide a mechanism of feedback control that is important for forespore development. SpoVT levels during spore formation have a major impact on the germination and the resistance of the resultant spores. To B.subtilis AbrB and Abh. (178 aa)
spoIIGAProtease processing pro-sigma-E; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. (309 aa)
sigERNA polymerase sporulation-specific sigma-29 factor (sigma-E); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. (239 aa)
sigGRNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes in the forespore. (260 aa)
spoVAFStage V sporulation protein AF; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (493 aa)
spoVAEAStage V sporulation germinant protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (203 aa)
spoVAEBSpore germinant protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (116 aa)
spoVADStage V sporulation protein AD; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (338 aa)
spoVACStage V sporulation protein AC; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (150 aa)
spoVABStage V sporulation protein AB; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (141 aa)
spoVAAStage V sporulation protein AA; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (206 aa)
sigFRNA polymerase sporulation-specific sigma factor (sigma-F); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. Interaction with SpoIIAB inhibits sigma-F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. Responsible for expression of csfB (the anti-sigma-G factor Gin). (255 aa)
spoIIABAnti-sigma factor (antagonist of sigma(F)) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)
spoIIAAAnti-anti-sigma factor (antagonist of SpoIIAB); In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition; Belongs to the anti-sigma-factor antagonist family. (117 aa)
gprSpore endopeptidase; Initiates the degradation of small, acid-soluble proteins during spore germination. (368 aa)
spoIIIDTranscriptional regulator; This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K). (93 aa)
spoIIRpro-sigma(E) endopeptidase (stage II sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (224 aa)
yyaCConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (205 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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