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yabG yabG cotP cotP ydgA ydgA ydgB ydgB cotA cotA yeeK yeeK yfnH yfnH yfnG yfnG yfnF yfnF yfnE yfnE yfnD yfnD yhcO yhcO gerPF gerPF gerPE gerPE gerPD gerPD gerPC gerPC gerPB gerPB gerPA gerPA yisZ yisZ yitA yitA yitB yitB slpH slpH slpS slpS yjzB yjzB cotZ cotZ cotY cotY cotX cotX cotW cotW cotV cotV yjcZ yjcZ spoVIF spoVIF cotT cotT ylbD ylbD ylbE ylbE spoVFA spoVFA spoVFB spoVFB ymaG ymaG cotU cotU cotC cotC cotM cotM gerT gerT yodI yodI cgeC cgeC cgeA cgeA cgeB cgeB ypqA ypqA yppG yppG spmB spmB spmA spmA yqcI yqcI ysnD ysnD ytlA ytlA ytlC ytlC ytlD ytlD ytcA ytcA ytcB ytcB ytcC ytcC ytxO ytxO cotS cotS cotSA cotSA cotI cotI yvdP yvdP cotR cotR cotB cotB cotH cotH cotG cotG spsL spsL spsK spsK spsJ spsJ spsI spsI spsG spsG spsF spsF spsE spsE spsD spsD spsC spsC spsB spsB spsA spsA yxeE yxeE cotF cotF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yabGSporulation-specific protease; Cleaves the spore coat proteins SpoIVA and SafA. May cooperate with tgl to mediate the temperature-dependent cross-linking of coat proteins like GerQ. (290 aa)
cotPSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (143 aa)
ydgAConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (80 aa)
ydgBConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (90 aa)
cotAOuter spore coat copper-dependent laccase; Involved in brown pigmentation during sporogenesis. (513 aa)
yeeKSpore associated protein; Part of the spore coat. (145 aa)
yfnHPutative glucose-1-phosphate cytidylyltransferase; Catalyzes the transfer of a CMP moiety from CTP to glucose 1- phosphate. (254 aa)
yfnGPutative CDP-sugar-dehydratase/epimerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (322 aa)
yfnFPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (303 aa)
yfnEPutative glycosyltransferase (complex carbohydrate synthase); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glycosyltransferase 2 family. (392 aa)
yfnDPutative glycosyltransferase (complex carbohydrate synthase); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (311 aa)
yhcOHypothetical protein; Evidence 5: No homology to any previously reported sequences. (322 aa)
gerPFSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (72 aa)
gerPESpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (133 aa)
gerPDSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (58 aa)
gerPCSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (205 aa)
gerPBSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (77 aa)
gerPASpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (73 aa)
yisZPutative adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
yitAPutative sulfate adenylyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the sulfate adenylyltransferase family. (389 aa)
yitBPutative phospho-adenylylsulfate sulfotransferase; Reduction of activated sulfate into sulfite; Belongs to the PAPS reductase family. CysH subfamily. (236 aa)
slpH2-phosphosulfolactate phosphatase; Evidence 2b: Function of strongly homologous gene; enzyme; Belongs to the ComB family. (228 aa)
slpSPhosphosulfolactate synthase; Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL) (By similarity). Is probably involved in the biosynthesis of L-sulfolactate, which is a major constituent of sporulating cells and mature spores. Belongs to the phosphosulfolactate synthase family. (252 aa)
yjzBConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16391061. (79 aa)
cotZSpore coat protein (insoluble fraction, outermost layer); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (148 aa)
cotYOuter spore coat protein (insoluble fraction); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (162 aa)
cotXSpore coat protein (insoluble fraction); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (172 aa)
cotWSpore coat protein (insoluble fraction); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (105 aa)
cotVSpore coat protein (insoluble fraction); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (128 aa)
yjcZPutative type I toxin; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. (49 aa)
spoVIFSporulation-specific protein needed for heat resistance; Transcription factor involved in spore coat assembly and spore resistance. Regulates the transcription of at least cgeA, cotG and cotS. (84 aa)
cotTSpore coat protein (inner coat); Inner spore coat protein which seems to play a role in germination. (82 aa)
ylbDConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (132 aa)
ylbEConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (79 aa)
spoVFASpore dipicolinate synthase subunit A; Together with DpaB, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA), which constitutes up to 10% of the dry weight of the spore. (297 aa)
spoVFBSpore dipicolinate synthase subunit B; Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA), which constitutes up to 10% of the dry weight of the spore. (200 aa)
ymaGInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (91 aa)
cotUSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (86 aa)
cotCSpore coat protein (outer); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (66 aa)
cotMSpore coat protein (outer); Involved in spore outer coat assembly. May be part of a cross-linked insoluble skeleton that surrounds the spore, serves as a matrix for the assembly of additional outer coat material, and confers structural stability to the final structure. (130 aa)
gerTComponent of the spore coat; Involved in spore germination; probably required at the earliest stage of germination. (157 aa)
yodIConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (83 aa)
cgeCProtein involved in maturation of the outermost layer of the spore; May be involved in maturation of the outermost layer of the spore. (101 aa)
cgeASpore outermost layer component; May be involved in maturation of the outermost layer of the spore. (133 aa)
cgeBProtein involved in maturation of the outermost layer of the spore; May be involved in maturation of the outermost layer of the spore. (317 aa)
ypqAHypothetical protein; Evidence 5: No homology to any previously reported sequences; Belongs to the small heat shock protein (HSP20) family. (139 aa)
yppGConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (125 aa)
spmBSpore maturation protein; Involved in spore core dehydration; might be involved in the transport of something into or out of the forespore or could be required for some modification of the cortex peptidoglycan structure; Belongs to the SpmB family. (178 aa)
spmASpore maturation protein; Involved in spore core dehydration; might be involved in the transport of something into or out of the forespore or could be required for some modification of the cortex peptidoglycan structure. (196 aa)
yqcIConserved hypothetical protein; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin; Belongs to the DcsA family. (254 aa)
ysnDInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (111 aa)
ytlAPutative ABC transporter component; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (334 aa)
ytlCPutative ABC transporter component, ATP-binding; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily. (260 aa)
ytlDPutative permease of ABC transporter; Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity). (270 aa)
ytcAPutative UDP-glucose dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. (428 aa)
ytcBPutative UDP-glucose epimerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (316 aa)
ytcCPutative glucosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (407 aa)
ytxOOuter spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (143 aa)
cotSSpore coat protein; Seems to be required for the assembly of the CotSA protein in spores. (351 aa)
cotSASpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (377 aa)
cotISpore coat kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (357 aa)
yvdPSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the oxygen-dependent FAD-linked oxidoreductase family. (447 aa)
cotRSpore coat protein assembly factor CotR; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (320 aa)
cotBSpore coat protein (outer); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (380 aa)
cotHSpore coat protein (inner); Involved in the assembly of several proteins in the inner and outer layer of the spore coat. Stabilizes CotC and CotU in the mother cell compartment of sporulating cells and promotes the assembly of both early and late forms of CotC-related polypeptides on the spore surface. Belongs to the CotH family. (362 aa)
cotGSpore morphogenetic protein; May be a morphogenetic protein that is required for the incorporation of protein CotB into the spore coat. (195 aa)
spsLdTDP-4-deoxyrhamnose-3,5-epimerase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (151 aa)
spsKPutative dTDP-4-dehydrorhamnose reductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (283 aa)
spsJdTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. (315 aa)
spsIGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (246 aa)
spsGPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To M.jannaschii MJ1062. (339 aa)
spsFPutative glycosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (240 aa)
spsEPutative phosphoenolpyruvate-sugar pyruvyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (373 aa)
spsDPutative TDP-glycosamine N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (289 aa)
spsCPutative glutamine-dependent sugar transaminase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DegT/DnrJ/EryC1 family. (389 aa)
spsBPutative dTDP glycosyl/glycerophosphate transferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (474 aa)
spsASpore coat dTDP-glycosyltransferase; Glycosyltransferase implicated in the synthesis of the spore coat; Belongs to the glycosyltransferase 2 family. (256 aa)
yxeEInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (121 aa)
cotFSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (160 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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