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rapC rapC phrC phrC rapH rapH phrH phrH rapA rapA phrA phrA rapK rapK phrK phrK degR degR rapE rapE phrE phrE yqzI yqzI yuxO yuxO comA comA comP comP comX comX comQ comQ degQ degQ rapD rapD rapF rapF phrF phrF rapG rapG phrG phrG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rapCResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. (382 aa)
phrCPhosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. (40 aa)
rapHResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the RAP family. (376 aa)
phrHHexapeptide inhibitor of regulatory cascade; Inhibitor of the activity of phosphatase RapH. May inhibit the rapH promoter after import into the cytoplasm. (57 aa)
rapAResponse regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family. (378 aa)
phrASecreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. (44 aa)
rapKPutative phage holin (fragment); Evidence 7: Gene remnant; extrachromosomal origin; Belongs to the RAP family. (371 aa)
phrKSecreted regulator of the activity of phosphatase RapK; Inhibitor of the activity of phosphatase RapK. (40 aa)
degRActivation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. (60 aa)
rapEResponse regulator aspartate phosphatase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type r: regulator; Belongs to the RAP family. (375 aa)
phrERegulator of the activity of phosphatase RapE; Inhibitor of the activity of phosphatase RapE. (44 aa)
yqzIHypothetical protein; Evidence 5: No homology to any previously reported sequences. (52 aa)
yuxOPutative esterase; Is not required for competence. (126 aa)
comATwo-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. (214 aa)
comPTwo-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation. (769 aa)
comXCompetence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified); Part of a major quorum-sensing system that regulates the development of genetic competence. Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA, that regulates directly the transcription of over 20 genes. Transport through the membrane may involve Spo0K. Under certain conditions plays a role in sporulation. (55 aa)
comQIsoprenyl transferase (pre-ComX modification); Involved in the maturation of ComX, part of a major quorum- sensing system that regulates the development of genetic competence. (299 aa)
degQPleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. (46 aa)
rapDResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; Belongs to the RAP family. (354 aa)
rapFResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (381 aa)
phrFSecreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. (39 aa)
rapGResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (365 aa)
phrGSecreted regulator of the activity of phosphatase RapG; Inhibitor of the activity of phosphatase RapG. (38 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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