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ycbJ ycbJ tmrB tmrB lrpC lrpC ydeI ydeI ydgC ydgC ydgD ydgD ydgE ydgE vmlR vmlR ydgF ydgF ydgG ydgG ydgH ydgH ydhH ydhH ydhI ydhI yfmK yfmK yhgD yhgD yhgE yhgE ykkC ykkC ykkD ykkD ebrB ebrB ebrA ebrA yoeA yoeA penP penP cspD cspD hbs hbs aadK aadK yvaC yvaC yvaD yvaD yvaE yvaE yvaF yvaF yvaG yvaG yvdS yvdS yvdR yvdR yxeJ yxeJ yxeI yxeI yxeH yxeH yxeG yxeG yxeF yxeF yyaR yyaR tetB tetB tetL tetL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ycbJPutative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family. (306 aa)
tmrBATP-binding tunicamycin resistance protein; Involved in the resistance to tunicamycin. Binds ATP. (197 aa)
lrpCTranscriptional regulator (Lrp/AsnC family); Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition. (144 aa)
ydeIConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (197 aa)
ydgCPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (195 aa)
ydgDConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (114 aa)
ydgEPutative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (157 aa)
vmlRATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] (547 aa)
ydgFPutative amino acid permease; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (458 aa)
ydgGPutative transcriptional regulator (MarR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (152 aa)
ydgHPutative membrane component; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. (885 aa)
ydhHConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (165 aa)
ydhIPutative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (160 aa)
yfmKPutative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (148 aa)
yhgDPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (191 aa)
yhgEPutative methyl-accepting protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (775 aa)
ykkCEfflux transporter; Probably involved in guanidinium transport. In vitro, confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials. (112 aa)
ykkDEfflux transporter; Probably involved in guanidinium transport. In vitro, confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials. (105 aa)
ebrBSmall multidrug efflux transporter; Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O. The efflux is probably coupled to an influx of protons (By similarity). (117 aa)
ebrASmall multidrug resistance efflux transporter; Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O. The efflux is probably coupled to an influx of protons (By similarity). (105 aa)
yoeAPutative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa)
penPBeta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. (306 aa)
cspDCold-shock protein, molecular chaperone, RNA-helicase co-factor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (66 aa)
hbsNon-specific DNA-binding protein HBsu; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds evenly across chromosome, does not display a preference for AT content. (92 aa)
aadKAminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. (284 aa)
yvaCPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (631 aa)
yvaDPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (133 aa)
yvaEPutative metabolite-efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (119 aa)
yvaFPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (190 aa)
yvaGPutative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
yvdSPutative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (111 aa)
yvdRPutative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (106 aa)
yxeJHypothetical protein; Evidence 5: No homology to any previously reported sequences. (75 aa)
yxeIPenicillin V acylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase C59 family. (328 aa)
yxeHPutative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (270 aa)
yxeGPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (185 aa)
yxeFLipocalin-like protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (144 aa)
yyaRPutative acetyl-transferase; Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin; Belongs to the acetyltransferase family. GNAT subfamily. (173 aa)
tetBMultifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. (458 aa)
tetLTetracycline resistance leader peptide; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. (20 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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