STRINGSTRING
walR walR ybdJ ybdJ ycbL ycbL ycbM ycbM natR natR yclJ yclJ yclK yclK dctR dctR citT citT ykoG ykoG cheB cheB resE resE resD resD yrkP yrkP lytT lytT phoP phoP bceR bceR yufM yufM cssR cssR yvrH yvrH yvcP yvcP yxdJ yxdJ walK walK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
walRTwo-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. (235 aa)
ybdJTwo-component response regulator [YbdK]; Member of the two-component regulatory system YbdK/YbdJ. (223 aa)
ycbLTwo-component response regulator [YcbM]; Member of the two-component regulatory system YcbM/YcbL. (226 aa)
ycbMTwo-component sensor histidine kinase [YcbL]; Member of the two-component regulatory system YcbM/YcbL. Probably activates YcbL by phosphorylation. (311 aa)
natRTwo-component response regulator [NatK]; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB. (233 aa)
yclJTwo-component response regulator [YclK]; Could be member of the two-component regulatory system YclK/YclJ. (227 aa)
yclKTwo-component sensor histidine kinase [YclJ]; Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ. (473 aa)
dctRTwo-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP. (226 aa)
citTTwo-component response regulator; Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM- yflN operon. (226 aa)
ykoGTwo-component response regulator [YkoH]; Probable member of the two-component regulatory system YkoH/YkoG. (228 aa)
cheBMethyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase; Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. B.subtilis has an effective methylation-independent adaptation system but must utilize the methylation system for adaptation to high concentrations of attractant; Belongs to the CheB family. (357 aa)
resETwo-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. (589 aa)
resDTwo-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa)
yrkPTwo-component response regulator [YrkQ]; Member of the two-component regulatory system YrkQ/YrkP. (231 aa)
lytTTwo-component response regulator [LytS]; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. (241 aa)
phoPTwo-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. (240 aa)
bceRSensory transduction protein BceR; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up- regulates the expression of these two genes. (231 aa)
yufMTwo-component response regulator [YufL]; Member of a two-component regulatory system MalK/MalR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region. (235 aa)
cssRTwo-component response regulator; Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress. (225 aa)
yvrHTwo-component response regulator YvrH involved in cell wall processes [YvrG]; Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA-yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX-rsiX), and negatively regulates the lytABC operon. (237 aa)
yvcPTwo-component response regulator [YvcQ]; Member of the two-component regulatory system YvcQ/YvcP. (237 aa)
yxdJTwo-component response regulator [YxdK]; Probable member of the two-component regulatory system YxdK/YxdJ. Positively regulates the expression of the yxdLMyxeA operon by direct interaction with its promoter region. Could also indirectly regulate the expression of the dlt operon. (229 aa)
walKTwo-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. (611 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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