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ybdJ ybdJ degA degA yhjM yhjM yhgD yhgD citR citR perR perR yfiR yfiR yezE yezE ydeS ydeS ycnC ycnC yclJ yclJ natR natR ycbL ycbL ccpB ccpB walR walR yxdJ yxdJ yxjO yxjO cysL cysL ywqM ywqM rbsR rbsR yvkB yvkB yvcP yvcP mdxR mdxR ganR ganR araR araR yvaP yvaP yvaF yvaF csoR csoR yvrH yvrH cssR cssR yusT yusT bceR bceR msmR msmR ccpA ccpA refZ refZ phoP phoP lytT lytT fadR fadR cymR cymR bscR bscR yraN yraN gltR gltR yrdQ yrdQ yrkP yrkP zur zur fur fur resD resD kdgR kdgR arxR arxR ftsR ftsR pksA pksA codY codY mraZ mraZ ccpC ccpC ykvZ ykvZ tnrA tnrA ykoG ykoG ohrR ohrR exuR exuR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ybdJTwo-component response regulator [YbdK]; Member of the two-component regulatory system YbdK/YbdJ. (223 aa)
degATranscriptional regulator (LacI family); Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease. (337 aa)
yhjMTranscriptional regulator of the ntd operon; Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription. (329 aa)
yhgDPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (191 aa)
citRTranscriptional regulator CitR (LysR family); Negative regulatory protein for the citA gene for citrate synthase I; Belongs to the LysR transcriptional regulatory family. (291 aa)
perRTranscriptional regulator (Fur family); Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA; Belongs to the Fur family. (145 aa)
yfiRTranscriptional regulator (TetR/AcrR family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (205 aa)
yezEPutative transcriptional regulator (TetR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (194 aa)
ydeSPutative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (198 aa)
ycnCPutative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (292 aa)
yclJTwo-component response regulator [YclK]; Could be member of the two-component regulatory system YclK/YclJ. (227 aa)
natRTwo-component response regulator [NatK]; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB. (233 aa)
ycbLTwo-component response regulator [YcbM]; Member of the two-component regulatory system YcbM/YcbL. (226 aa)
ccpBTranscriptional repressor of carbon supply (LacI family); Transcriptional regulator involved in catabolite repression of several operons. (311 aa)
walRTwo-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. (235 aa)
yxdJTwo-component response regulator [YxdK]; Probable member of the two-component regulatory system YxdK/YxdJ. Positively regulates the expression of the yxdLMyxeA operon by direct interaction with its promoter region. Could also indirectly regulate the expression of the dlt operon. (229 aa)
yxjOPutative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family. (291 aa)
cysLRegulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. (299 aa)
ywqMPutative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (293 aa)
rbsRTranscriptional regulator (LacI family); Transcriptional repressor for the ribose rbsDACBK operon. (326 aa)
yvkBPutative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (189 aa)
yvcPTwo-component response regulator [YvcQ]; Member of the two-component regulatory system YvcQ/YvcP. (237 aa)
mdxRTranscriptional activator of the maltodextrin operon (LacI family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type pr: putative regulator. (316 aa)
ganRTranscriptional regulator (LacI family); Negatively regulates expression of ganA. (330 aa)
araRTranscriptional repressor of the ara regulon (LacI family); Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene, and to one sequence in the araR promoter. (362 aa)
yvaPPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (108 aa)
yvaFPutative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (190 aa)
csoRRepressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. (101 aa)
yvrHTwo-component response regulator YvrH involved in cell wall processes [YvrG]; Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA-yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX-rsiX), and negatively regulates the lytABC operon. (237 aa)
cssRTwo-component response regulator; Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress. (225 aa)
yusTPutative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the LysR transcriptional regulatory family. (295 aa)
bceRSensory transduction protein BceR; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up- regulates the expression of these two genes. (231 aa)
msmRTranscriptional regulator (LacI family); Represses the melibiose operon melREDCA in the absence of melibiose or raffinose. Binds to two binding sites at the promoter region of the operon. (344 aa)
ccpATranscriptional regulator (Lacl family); Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P- Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons. (334 aa)
refZRegulator of FtsZ; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (207 aa)
phoPTwo-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. (240 aa)
lytTTwo-component response regulator [LytS]; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. (241 aa)
fadRTranscriptional regulator of fatty acids degradation (TetR/AcrR family); Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length. (194 aa)
cymRTranscriptional regulator of cysteine biosynthesis; Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the Cy [...] (138 aa)
bscRTranscriptional regulator for cypB; Negatively regulates the transcription of the fatR-cypB operon. Is displaced from its operator by a range of fatty acids such as oleate, linoleate and phytanate, thereby allowing transcription of the fatR-cypB operon. (194 aa)
yraNPutative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the LysR transcriptional regulatory family. (289 aa)
gltRTranscriptional regulator (LysR family); Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression; Belongs to the LysR transcriptional regulatory family. (296 aa)
yrdQPutative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the LysR transcriptional regulatory family. (288 aa)
yrkPTwo-component response regulator [YrkQ]; Member of the two-component regulatory system YrkQ/YrkP. (231 aa)
zurTranscriptional regulator (Fur family); Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes. Required for the zinc-specific repression of two operons implicated in zinc uptake, yciC and ycdHIyceA. Also represses the expression of rpmE2, the gene for ribosomal protein L31B, which is expressed only after the end of exponential growth. (145 aa)
furTranscriptional regulator for iron transport and metabolism; Iron uptake repressor. Acts on the transcription of ferri- siderophore uptake genes. (149 aa)
resDTwo-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa)
kdgRKdg operon transcriptional regulator (LacI family); Transcriptional repressor of the kdgRKAT and kduID operons for pectin utilization. (339 aa)
arxRTranscriptional repressor; Negatively regulates yodC and azoR1 which may contribute to the degradation of aromatic compounds. Probably positively regulates the catechol-specific transcription of mhqNOP, mhqED, and mhqA. (112 aa)
ftsRTranscriptional regulator (LysR family); Regulates expression of the cell division protein ftsW, and is essential for cell viability during stationary phase. (285 aa)
pksAPutative transcriptional regulator; Transcriptional regulation of the polyketide synthase operon. (205 aa)
codYTranscriptional regulator, GTP and BCAA-dependent; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP- binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor. (259 aa)
mraZPutative protein involved in cell division or replication; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp: cell process; Belongs to the MraZ family. (143 aa)
ccpCTranscriptional repressor of citB and citZ; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; Belongs to the LysR transcriptional regulatory family. (293 aa)
ykvZPutative transcriptional regulator (LacI family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (321 aa)
tnrANitrogen sensing transcriptional regulator; Transcription regulator that actives the transcription of genes required for nitrogen assimilation such as nrgAB (ammonium transport), nasABCDEF (nitrate/nitrite assimilation), ureABC (urea degradation) and gabP (GABA transport), during nitrogen limitation. Also represses glnRA and gltAB in the absence of ammonium. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, TnrA requires a DNA sequence of 17 nucleotides as minimal binding site. (110 aa)
ykoGTwo-component response regulator [YkoH]; Probable member of the two-component regulatory system YkoH/YkoG. (228 aa)
ohrRTranscriptional regulator sensing organic peroxides; Organic peroxide sensor. Represses the expression of the peroxide-inducible gene ohrA by cooperative binding to two inverted repeat elements. (147 aa)
exuRTranscriptional regulator (LacI family); Transcriptional repressor for the exu locus which is required for galacturonate utilization. (333 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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