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yocS yocS natB natB putP putP gutP gutP opuE opuE yflA yflA nhaC nhaC glnT glnT exuM exuM xynP xynP alsT alsT natA natA mleN mleN yqeW yqeW yrbD yrbD maeN maeN mrpA mrpA mrpB mrpB mrpC mrpC mrpD mrpD mrpE mrpE mrpF mrpF mrpG mrpG nhaK nhaK ywcA ywcA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yocSPutative sodium-dependent transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (321 aa)
natBNa+ ABC efflux transporter (permease); Part of an ABC transporter that catalyzes ATP-dependent electrogenic sodium extrusion. (386 aa)
putPProline permease; Catalyzes the high-affinity uptake of extracellular proline. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (473 aa)
gutPH+-glucitol symporter; Probably involved in glucitol uptake; Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (463 aa)
opuEProline transporter; Catalyzes the uptake of extracellular proline under high- osmolarity growth conditions. Essential for the use of proline present in the environment as an osmoprotectant. (492 aa)
yflAPutative aminoacid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa)
nhaCNa+/H+ antiporter; Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system. (453 aa)
glnTGlutamine transporter; Probably functions as a sodium/glutamine symporter for glutamine uptake; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (478 aa)
exuMPutative Na+:altronate/mannonate symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t: transporter. (459 aa)
xynPPutative H+-xyloside symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa)
alsTAmino acid carrier protein; Evidence 2b: Function of strongly homologous gene; Product type t: transporter; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (465 aa)
natANa+ ABC efflux transporter (ATP-binding protein); Part of an ABC transporter that catalyzes ATP-dependent electrogenic sodium extrusion; Belongs to the ABC transporter superfamily. (246 aa)
mleNmalate-H+/Na+-lactate antiporter; Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force; Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter family. (468 aa)
yqeWPutative Na+/anion cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (307 aa)
yrbDSodium/proton-dependent alanine transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; transporter. (484 aa)
maeNNa+/malate symporter; Acts as a Na(+)-malate symporter, as it catalyzes malate- dependent uptake of Na(+) and Na(+)-dependent uptake of malate. (448 aa)
mrpASodium transporter component of a Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs [...] (801 aa)
mrpBNa+/H+ antiporter complex; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporters (T [...] (143 aa)
mrpCComponent of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporte [...] (113 aa)
mrpDProton transporter component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to [...] (493 aa)
mrpENon essential component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the [...] (158 aa)
mrpFEfflux transporter for Na+ and cholate; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). (94 aa)
mrpGNon essential component of Na+/H+ antiporter; May enhance MrpA stability, assembly, or function. May play chaperone or assembly roles for MrpA and perhaps for other mrp proteins. (124 aa)
nhaKNa+/H+ antiporter; Transporter involved in the efflux of sodium, potassium, lithium and rubidium. (670 aa)
ywcAPutative acetate Na+-dependent symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (513 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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