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yhjB yhjB ybaR ybaR ybeC ybeC glpT glpT gltP gltP glnT glnT tatCD tatCD lctP lctP putP putP mntH mntH dctP dctP tatCY tatCY gutP gutP iolT iolT opuE opuE citM citM yflA yflA yfkE yfkE yfiG yfiG tcyP tcyP yhdH yhdH nhaC nhaC yhaU yhaU gltT gltT yisQ yisQ yjbQ yjbQ manP manP yjkB yjkB exuM exuM pit pit fruA fruA cysP cysP xynP xynP yncC yncC alsT alsT yoeA yoeA yocR yocR yocS yocS norM norM dinF dinF kdgT kdgT mleN mleN pstBB pstBB pstBA pstBA pstA pstA pstC pstC yqeW yqeW arsB arsB yraO yraO yrbD yrbD ktrB ktrB maeN maeN mrpA mrpA mrpB mrpB mrpC mrpC mrpD mrpD mrpE mrpE mrpF mrpF mrpG mrpG yutK yutK lysP lysP nhaK nhaK araE araE yvfH yvfH yveA yveA yvdB yvdB ywtG ywtG ywcA ywcA ywbF ywbF cimH cimH nupG nupG citH citH nupC nupC csbC csbC tetB tetB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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yhjBPutative Na+/metabolite cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (489 aa)
ybaRPutative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m: membrane component. (478 aa)
ybeCPutative H+/amino acid transporter; Uptake of an yet unknown amino-acid with the concomitant import of a proton; Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family. (539 aa)
glpTGlycerol-3-phosphate permease; Responsible for glycerol-3-phosphate uptake; Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. (444 aa)
gltPProton/glutamate symport protein; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (414 aa)
glnTGlutamine transporter; Probably functions as a sodium/glutamine symporter for glutamine uptake; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (478 aa)
tatCDComponent of the twin-arginine pre-protein translocation pathway; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Required for PhoD secretion. TatCd promotes membrane localization of TatAd via domain specific interactions. TatCd is required for stabile production of TatAd as well as for its maintenance; Belongs to the TatC family. (242 aa)
lctPL-lactate permease; May play a role in L-lactate transport. (541 aa)
putPProline permease; Catalyzes the high-affinity uptake of extracellular proline. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (473 aa)
mntHManganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. (425 aa)
dctPC4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. (421 aa)
tatCYComponent of the twin-arginine pre-protein translocation pathway; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Required for YwbN secretion; Belongs to the TatC family. (254 aa)
gutPH+-glucitol symporter; Probably involved in glucitol uptake; Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (463 aa)
iolTMyo-inositol transporter; Major myo-inositol uptake transporter. (473 aa)
opuEProline transporter; Catalyzes the uptake of extracellular proline under high- osmolarity growth conditions. Essential for the use of proline present in the environment as an osmoprotectant. (492 aa)
citMTransporter of divalent metal ions/citrate complexes; Proton motive force-driven secondary transporter that mediates the transport of citrate complexed to Mg(2+). Cotransports at least two protons per Mg(2+)-citrate complex. Can also transport citrate in complex with Ni(2+), Mn(2+), Co(2+), and Zn(2+); Belongs to the CitM (TC 2.A.11) transporter family. (433 aa)
yflAPutative aminoacid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa)
yfkEPutative H+/Ca2+ antiporter; Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons. Does not transport sodium or potassium. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily. (351 aa)
yfiGPutative sugar transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (482 aa)
tcyPSodium-cystine symporter; Mediates uptake of L-cystine, the oxidized form of L- cysteine. Although it is more specific for L-cystine, it could also transport a much broader range of amino acids and sulfur compounds including S-methylcysteine; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
yhdHPutative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (451 aa)
nhaCNa+/H+ antiporter; Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system. (453 aa)
yhaUTransporter involved in K+ efflux; Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Can also mediate rubidium/proton antiport, but has no permeability for sodium or lithium ions. In the absence of KhtT, does not have antiport activity, but can catalyze potassium efflux. Involved in protection of the cell from methylglyoxal, a toxic by-product of glycolysis, via activation by S-lactoyl-BSH of the antiporter activity, leading to cytoplasmic acidification and methylglyoxal resistance ; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transpo [...] (405 aa)
gltTProton/sodium-glutamate symport protein; This carrier protein is part of the Na(+)-dependent, binding- protein-independent glutamate-aspartate transport system. (429 aa)
yisQPutative Na+driven efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (455 aa)
yjbQPutative Na+/H+ antiporter; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (614 aa)
manPPhosphotransferase system (PTS) mannose-specific enzyme IIBCA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. (650 aa)
yjkBPutative phosphate ABC transporter (ATP-binding protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily. (250 aa)
exuMPutative Na+:altronate/mannonate symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t: transporter. (459 aa)
pitLow-affinity inorganic phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. (333 aa)
fruAPhosphotransferase system (PTS) fructose-specific enzyme IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. (635 aa)
cysPSulfate permease; Involved in the import of sulfate. (354 aa)
xynPPutative H+-xyloside symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa)
yncCPutative sugar transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa)
alsTAmino acid carrier protein; Evidence 2b: Function of strongly homologous gene; Product type t: transporter; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (465 aa)
yoeAPutative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa)
yocRPutative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (445 aa)
yocSPutative sodium-dependent transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (321 aa)
norMMatE Na+-driven efflux family protein; Multidrug efflux pump; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (452 aa)
dinFDamage inducible, Na+ driven multidrug efflux pump; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; transporter. (445 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity). (330 aa)
mleNmalate-H+/Na+-lactate antiporter; Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force; Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter family. (468 aa)
pstBBPhosphate ABC transporter (ATP-binding protein); Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (260 aa)
pstBAPhosphate ABC transporter (ATP-binding protein); Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (269 aa)
pstAPhosphate ABC transporter (permease); Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (294 aa)
pstCPhosphate ABC transporter (permease); Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (309 aa)
yqeWPutative Na+/anion cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (307 aa)
arsBArsenite efflux transporter; Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. (346 aa)
yraOPutative citrate transporter; Transports the free citrate anion; Belongs to the CitM (TC 2.A.11) transporter family. (438 aa)
yrbDSodium/proton-dependent alanine transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; transporter. (484 aa)
ktrBPotassium transporter ATPase; Integral membrane subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress. (445 aa)
maeNNa+/malate symporter; Acts as a Na(+)-malate symporter, as it catalyzes malate- dependent uptake of Na(+) and Na(+)-dependent uptake of malate. (448 aa)
mrpASodium transporter component of a Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs [...] (801 aa)
mrpBNa+/H+ antiporter complex; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporters (T [...] (143 aa)
mrpCComponent of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the CPA3 antiporte [...] (113 aa)
mrpDProton transporter component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to [...] (493 aa)
mrpENon essential component of Na+/H+ antiporter; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). Belongs to the [...] (158 aa)
mrpFEfflux transporter for Na+ and cholate; Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+). (94 aa)
mrpGNon essential component of Na+/H+ antiporter; May enhance MrpA stability, assembly, or function. May play chaperone or assembly roles for MrpA and perhaps for other mrp proteins. (124 aa)
yutKPutative Na+(H+)/nucleoside cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (404 aa)
lysPLysine permease; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (469 aa)
nhaKNa+/H+ antiporter; Transporter involved in the efflux of sodium, potassium, lithium and rubidium. (670 aa)
araEArabinose-related compounds permease; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). (464 aa)
yvfHPutative lactate permease; Is the principal permease for the uptake of L-lactate in B.subtilis. (563 aa)
yveAL-aspartate/L-glutamate permease; Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency. (520 aa)
yvdBPutative anion transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (530 aa)
ywtGPutative carbohydrate transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (457 aa)
ywcAPutative acetate Na+-dependent symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (513 aa)
ywbFPutative sugar permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (399 aa)
cimHcitrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. (450 aa)
nupGPurine nucleoside transporter; Involved in the uptake of the purine ribonucleosides inosine and guanosine. (397 aa)
citHSecondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. (426 aa)
nupCPyrimidine-nucleoside Na+(H+) cotransporter; Transport of the pyrimidine nucleoside uridine. (393 aa)
csbCPutative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (461 aa)
tetBMultifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. (458 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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