STRINGSTRING
ybeC ybeC gltP gltP glnT glnT lctP lctP putP putP mntH mntH dctP dctP gutP gutP iolT iolT opuE opuE citM citM yflA yflA yfiG yfiG tcyP tcyP yhdH yhdH gltT gltT yhjB yhjB manP manP exuM exuM fruA fruA xynP xynP yncC yncC alsT alsT yocR yocR yocS yocS kdgT kdgT yqeW yqeW yraO yraO yrbD yrbD ktrB ktrB maeN maeN yutK yutK araE araE yvfH yvfH yveA yveA ywtG ywtG ywcA ywcA ywbF ywbF cimH cimH nupG nupG citH citH nupC nupC csbC csbC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ybeCPutative H+/amino acid transporter; Uptake of an yet unknown amino-acid with the concomitant import of a proton; Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family. (539 aa)
gltPProton/glutamate symport protein; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (414 aa)
glnTGlutamine transporter; Probably functions as a sodium/glutamine symporter for glutamine uptake; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (478 aa)
lctPL-lactate permease; May play a role in L-lactate transport. (541 aa)
putPProline permease; Catalyzes the high-affinity uptake of extracellular proline. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source. (473 aa)
mntHManganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth. (425 aa)
dctPC4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. (421 aa)
gutPH+-glucitol symporter; Probably involved in glucitol uptake; Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (463 aa)
iolTMyo-inositol transporter; Major myo-inositol uptake transporter. (473 aa)
opuEProline transporter; Catalyzes the uptake of extracellular proline under high- osmolarity growth conditions. Essential for the use of proline present in the environment as an osmoprotectant. (492 aa)
citMTransporter of divalent metal ions/citrate complexes; Proton motive force-driven secondary transporter that mediates the transport of citrate complexed to Mg(2+). Cotransports at least two protons per Mg(2+)-citrate complex. Can also transport citrate in complex with Ni(2+), Mn(2+), Co(2+), and Zn(2+); Belongs to the CitM (TC 2.A.11) transporter family. (433 aa)
yflAPutative aminoacid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa)
yfiGPutative sugar transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (482 aa)
tcyPSodium-cystine symporter; Mediates uptake of L-cystine, the oxidized form of L- cysteine. Although it is more specific for L-cystine, it could also transport a much broader range of amino acids and sulfur compounds including S-methylcysteine; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
yhdHPutative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (451 aa)
gltTProton/sodium-glutamate symport protein; This carrier protein is part of the Na(+)-dependent, binding- protein-independent glutamate-aspartate transport system. (429 aa)
yhjBPutative Na+/metabolite cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (489 aa)
manPPhosphotransferase system (PTS) mannose-specific enzyme IIBCA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. (650 aa)
exuMPutative Na+:altronate/mannonate symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t: transporter. (459 aa)
fruAPhosphotransferase system (PTS) fructose-specific enzyme IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. (635 aa)
xynPPutative H+-xyloside symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (463 aa)
yncCPutative sugar transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa)
alsTAmino acid carrier protein; Evidence 2b: Function of strongly homologous gene; Product type t: transporter; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (465 aa)
yocRPutative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (445 aa)
yocSPutative sodium-dependent transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (321 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity). (330 aa)
yqeWPutative Na+/anion cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (307 aa)
yraOPutative citrate transporter; Transports the free citrate anion; Belongs to the CitM (TC 2.A.11) transporter family. (438 aa)
yrbDSodium/proton-dependent alanine transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; transporter. (484 aa)
ktrBPotassium transporter ATPase; Integral membrane subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress. (445 aa)
maeNNa+/malate symporter; Acts as a Na(+)-malate symporter, as it catalyzes malate- dependent uptake of Na(+) and Na(+)-dependent uptake of malate. (448 aa)
yutKPutative Na+(H+)/nucleoside cotransporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (404 aa)
araEArabinose-related compounds permease; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). (464 aa)
yvfHPutative lactate permease; Is the principal permease for the uptake of L-lactate in B.subtilis. (563 aa)
yveAL-aspartate/L-glutamate permease; Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency. (520 aa)
ywtGPutative carbohydrate transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (457 aa)
ywcAPutative acetate Na+-dependent symporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (513 aa)
ywbFPutative sugar permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (399 aa)
cimHcitrate/malate/H+ symporter; Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate. (450 aa)
nupGPurine nucleoside transporter; Involved in the uptake of the purine ribonucleosides inosine and guanosine. (397 aa)
citHSecondary transporter of divalent metal ions/citrate complexes; Transports the free citrate anion. Probably cotransports citrate and at least three or four protons. The citrate uptake is inhibited by the presence of magnesium ions; Belongs to the CitM (TC 2.A.11) transporter family. (426 aa)
nupCPyrimidine-nucleoside Na+(H+) cotransporter; Transport of the pyrimidine nucleoside uridine. (393 aa)
csbCPutative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (461 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.