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| | ribC | Bifunctional riboflavin kinase FAD synthase; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. (316 aa) |
| | dnaN | DNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] (378 aa) |
| | recF | DNA repair and genetic recombination factor; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. Is recruited to repair centers, foci that are the site of double- strand DNA break(s) after RecN and RecO; recruitment may depend on RecO. (370 aa) |
| | guaB | Inosine-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (488 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | dck | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] (217 aa) |
| | dgk | Deoxyguanosine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as phosphate donor than CTP, ATP and GTP. (207 aa) |
| | dnaX | DNA polymerase III (gamma and tau subunits); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. (563 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | holB | DNA polymerase III delta' subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. (329 aa) |
| | gcaD | Bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belon [...] (456 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (317 aa) |
| | hprT | Hypoxanthine-guanine phosphoribosyltransferase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (180 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Cannot utilize a phosphoryl donor other than ATP; Belongs to the type III pantothenate kinase family. (258 aa) |
| | sigH | RNA polymerase sigma-30 factor (sigma(H)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in the transition to post- exponential phase in the beginning of sporulation. It is also required for transcription of several stationary phase genes. (218 aa) |
| | nusG | Transcription antitermination factor; Participates in transcription elongation, termination and antitermination. Stimulates RNA polymerase pausing at U107 and U144 in the trp leader. NusG-stimulated pausing is sequence specific. Does not affect trp leader termination. (177 aa) |
| | rpoB | RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1193 aa) |
| | rpoC | RNA polymerase (beta' subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | rpoA | RNA polymerase (alpha subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa) |
| | sigW | RNA polymerase ECF(extracytoplasmic function)-type sigma factor W; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-W controls genes involved in response to cell envelope stress such as antimicrobial peptides , alkaline pH , transport processes and detoxification. (187 aa) |
| | ybbP | Putative enzyme with DAC domain protein; One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di- AMP synthesis. Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis. In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess. (273 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity). Glucosamine-1-phosphate is used for cell wall biosynthesis (Probable); Belongs to the phosphohexose mutase family. (448 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP. (384 aa) |
| | nadE | Ammonium-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (272 aa) |
| | sigB | RNA polymerase sigma-37 factor (sigma(B)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation. May play a role in the ability of the bacterium to adapt to various stresses but is not essential for its survival under these conditions. Positively regulates expression of its own operon; Belongs to the sigma-70 fac [...] (262 aa) |
| | guaA | GMP synthetase; Catalyzes the synthesis of GMP from XMP. (513 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (380 aa) |
| | purB | Adenylosuccinate lyase; Influences the affinity of glutamyl--tRNA ligase for its substrates and increases its thermostability; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purC | Phosphoribosylaminoimidazole succinocarboxamide synthetase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the SAICAR synthetase family. (241 aa) |
| | purS | Factor required for phosphoribosylformylglycinamidine synthetase activity; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and Pu [...] (84 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (227 aa) |
| | purL | Phosphoribosylformylglycinamidine synthetase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assis [...] (742 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (476 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; enzyme. (346 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (195 aa) |
| | purH | Fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; enzyme. (512 aa) |
| | purD | Phosphoribosylglycinamide synthetase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (422 aa) |
| | acoA | Acetoin dehydrogenase E1 component (TPP-dependent alpha subunit); Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme (By similarity). (333 aa) |
| | acoC | Acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (398 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (386 aa) |
| | pgcA | Alpha-phosphoglucomutase; Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required fo [...] (581 aa) |
| | sigM | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (YhdL) until released. This sigma factor is involved in the maintenance of membrane and cell wall integrity in response to environmental stresses including salt, acid, ethanol and antibiotics stress. Partially regulates transcription from a number of genes including disA. (163 aa) |
| | yitI | Putative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (149 aa) |
| | carA | Arginine-specific carbamoyl-phosphate synthetase (small subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (353 aa) |
| | carB | Arginine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. (1030 aa) |
| | relP | (p)ppGpp synthetase; Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The enzyme binds ATP, then GDP or GTP and catalysis is highly cooperative. In eubacteria ppGpp (guanosine 3'- diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Probably has a minor role in the stringent response ; Belongs to the RelA/SpoT family. (211 aa) |
| | ppnKA | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (GTP, UTP) as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. (266 aa) |
| | yjcF | Putative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family. (140 aa) |
| | xpf | Putative RNA polymerase PBSX sigma factor-like; Positive regulatory protein that acts at the late promoter PL. (169 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (300 aa) |
| | ykoU | ATP-dependent DNA ligase subunit; With Ku forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity (Probable). Probably involved in DNA repair during spore germination. In the N-terminal section; belongs to the LigD polymerase family. (611 aa) |
| | sigI | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of cell wall metabolism in response to heat stress. Acts by regulating the expression of genes such as bcrC, mreBH and lytE. Also plays a role in survival at low temperatures. Belongs to the sigma-70 factor family. SigI subfamily. (251 aa) |
| | queC | Pre-queuosine 0 synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Uses ammonia as nitrogen donor. (219 aa) |
| | queD | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Belongs to the PTPS family. QueD subfamily. (149 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (243 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway; Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (165 aa) |
| | rnpZA | Omega 1 subunit of RNA polymerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the UPF0356 family. (69 aa) |
| | pdhA | Pyruvate dehydrogenase (E1 alpha subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa) |
| | ylaC | RNA polymerase ECF-type sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor contributes to oxidative stress resistance. (173 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | sigE | RNA polymerase sporulation-specific sigma-29 factor (sigma-E); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. (239 aa) |
| | sigG | RNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes in the forespore. (260 aa) |
| | pyrR | Transcriptional attenuator and uracil phosphoribosyltransferase activity; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (181 aa) |
| | pyrB | Aspartate carbamoyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (304 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (428 aa) |
| | pyrAA | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Evidence 2b: Function of strongly homologous gene; enzyme. (364 aa) |
| | pyrAB | Pyrimidine-specific carbamoyl-phosphate synthetase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the CarB family. (1071 aa) |
| | pyrK | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD subunit to the ultimate electron acceptor NAD(+); Belongs to the PyrK family. (256 aa) |
| | pyrD | Dihydroorotate dehydrogenase (catalytic subunit); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. (311 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | rpoZ | Omega subunit of RNA polymerase; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (67 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | priA | Primosomal replication factor Y (primosomal protein N'); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (805 aa) |
| | fliI | Flagellar-specific ATPase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. (438 aa) |
| | sigD | RNA polymerase sigma-28 factor (sigma-D); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This alternative sigma factor is required for the transcription of the flagellin and motility genes as well as for wild- type chemotaxis. (254 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP, with ATP or dATP as the most efficient phosphate donors. Is also able to phosphorylate 5-fluoro-UMP and 6-aza-UMP. (240 aa) |
| | polC | DNA polymerase III (alpha subunit); Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity; Belongs to the DNA polymerase type-C family. PolC subfamily. (1437 aa) |
| | nusA | Transcription translation coupling factor involved in Rho-dependent transcription termination; Participates in both transcription termination and antitermination. (371 aa) |
| | nrdE | Ribonucleoside-diphosphate reductase (major subunit); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (700 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase (minor subunit); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (329 aa) |
| | yncF | Deoxyuridine 5'-triphosphate pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (144 aa) |
| | thyA | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa) |
| | yngHA | Biotin carboxylase/methylcrotonoyl-CoA carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (444 aa) |
| | yobH | Putative DNA repair protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the DNA polymerase type-Y family. (217 aa) |
| | yozK | Putative DNA repair protein fragment; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. (115 aa) |
| | yojJ | Putative enzyme with DAC domain; One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di- AMP synthesis. Overexpression of the hyperactive mutant (L44F) in the absence of c-di-AMP phosphodiesterase GdpP leads to growth defects in log phase (long curly cell filaments) that disappear upon sporulation; spore formation is normal, showing sporulation is insensitive to the excess c-di-AMP. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...] (207 aa) |
| | yosS | SPbeta phage deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (142 aa) |
| | yosP | Ribonucleoside-diphosphate reductase 2, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity); Belongs to the ribonucleoside diphosphate reductase small chain family. (329 aa) |
| | nrdEB | SPbeta phage ribonucleoside reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity); Belongs to the ribonucleoside diphosphate reductase large chain family. (1084 aa) |
| | yorL | Putative DNA polymerase; Probable DNA polymerase; Belongs to the DNA polymerase type-C family. (1305 aa) |
| | yonO | Conserved hypothetical protein; A single subunit DNA-dependent RNA polymerase (RNAP) that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates (rNTPs) as substrates. The enzyme is more highly processive than the multisubunit RNAP from E.coli but is considerably more error-prone. It has no detectable proof-reading function but can perform pyrophosphorolysis. Transcribes the late genes of the SPbeta prophage starting from yonK (approximately 35 genes are encoded in the prophage downstream from yonK). (839 aa) |
| | uvrX | Lesion bypass phage DNA polymerase; Evidence 2b: Function of strongly homologous gene; enzyme. (416 aa) |
| | thyB | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | ypdP | Putative integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (229 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. (194 aa) |
| | dnaD | DNA-remodelling primosomal protein; Probable component of primosome involved in the initiation of DNA replication. (232 aa) |
| | dinG | Damage inducible ATP-dependent 3'->5' nuclease; 3'-5' exonuclease. (931 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | mtrB | Tryptophan operon RNA-binding attenuation protein (TRAP); Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. (75 aa) |
| | cmk | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. (224 aa) |
| | sigX | RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. May be involved in the regulation of iron metabolism; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | sigF | RNA polymerase sporulation-specific sigma factor (sigma-F); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. Interaction with SpoIIAB inhibits sigma-F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. Responsible for expression of csfB (the anti-sigma-G factor Gin). (255 aa) |
| | polYB | Y family DNA polymerase V bypassing lesions during replication; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). (412 aa) |
| | coaA | Pantothenate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type pe: putative enzyme. (319 aa) |
| | polYA | DNA-damage lesion bypass DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). (414 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | nusB | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (131 aa) |
| | accC | acetyl-CoA carboxylase subunit (biotin carboxylase subunit); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | sigA | RNA polymerase major sigma-43 factor (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth; Belongs to the sigma-70 factor family. RpoD/SigA subfamily. (371 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (603 aa) |
| | holA | DNA polymerase delta subunit; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (347 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD); Belongs to the NadD family. (189 aa) |
| | spoIVCA | RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half); Putative site-specific recombinase having a very important role in sporulation. It probably plays a role in the recombination of SpoIIIC and SpoIVCB to form sigma K factor. (500 aa) |
| | yrkS | RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (54 aa) |
| | sigZ | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (176 aa) |
| | sigV | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. (166 aa) |
| | greA | Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity); Belongs to the GreA/GreB family. (157 aa) |
| | udk | Uridine kinase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (211 aa) |
| | rsh | GTP pyrophosphokinase (RelA/SpoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp, it is probably the hydrolysis activity that is required for optimal growth (Probable); Belongs to the RelA/SpoT family. (734 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (381 aa) |
| | queA | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (368 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). (289 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa) |
| | polX | DNA polymerase/3'-5' exonuclease X; Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a single-nucleotide gap, allowing further sealing of the resulting nick by a DNA ligase, points to a putative role in base excision repair (BER) during the B.subtilis life cycle. Moreover, also possesses a 3'-5' exonuclease activity able to edit unpaired 3'-termini in a gapped DNA substrate and likely invo [...] (570 aa) |
| | dnaI | Helicase loader; Probably involved in DNA replication. (311 aa) |
| | dnaB | Helicase loading protein; Probable component of primosome involved in the initiation of DNA replication. It is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110. (472 aa) |
| | coaE | Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. (880 aa) |
| | accA | acetyl-CoA carboxylase (carboxyltransferase alpha subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. Belongs to the AccA family. (325 aa) |
| | accD | acetyl-CoA carboxylase (carboxyltransferase beta subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (290 aa) |
| | dnaE | DNA polymerase III (alpha subunit); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. (1115 aa) |
| | rbfK | RNA-binding cryptic riboflavin kinase regulatory protein; May be directly involved in the regulation of the rib genes. C-terminal part of RibR specifically binds to RFN of the rib leader of the riboflavin biosynthetic operon. The RFN element is a sequence within the rib-leader mRNA reported to serve as a receptor for an FMN- dependent riboswitch. Possibly, RibR produces the comodulator FMN through its own N-terminal flavokinase activity. FMN-activated RibR may stabilize the anti-anti terminator structure of RFN mRNA, causing transcription termination of the rib genes in trans. (230 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Appears to favor the formation of acetate. Involved in the secretion of excess carbohydrate. (395 aa) |
| | ppnKB | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (267 aa) |
| | acsA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity). Has a role in growth and sporulation on acetate. (572 aa) |
| | ytcA | Putative UDP-glucose dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. (428 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (490 aa) |
| | yukF | Putative transcriptional regulator; Mediates ald expression in response to alanine availability and is important for normal sporulation in B.subtilis. Belongs to the CdaR family. (422 aa) |
| | sigO | Alternative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Together with its coactivator RsoA, positively regulates the expression of at least three operons, including oxdC-yvrL, sigO-rsoA and yvrJ. Required for the acid stress-dependent induction of the oxalate decarboxylase oxdC. (176 aa) |
| | sigL | RNA polymerase sigma-54 factor (sigma-L); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the levanase operon. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein LevR for the expression of the levanase operon. (436 aa) |
| | tuaD | UDP-glucose 6-dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (461 aa) |
| | ywqF | UDP-glucose dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (440 aa) |
| | murAA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Essential for cell growth; Belongs to the EPSP synthase family. MurA subfamily. (436 aa) |
| | atpC | ATP synthase (subunit epsilon, F1 subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. (132 aa) |
| | atpD | ATP synthase (subunit beta, component F1); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (473 aa) |
| | atpG | ATP synthase (subunit gamma, component F1); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | ATP synthase (subunit alpha, component F1); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit; Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase (subunit delta, component F1); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (181 aa) |
| | atpF | ATP synthase (subunit b, component F0); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa) |
| | atpE | ATP synthase (subunit c, component F0); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (70 aa) |
| | atpB | ATP synthase (subunit a, component F0); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (244 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | tdk | Thymidine kinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (195 aa) |
| | rho | Transcriptional terminator Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (427 aa) |
| | murAB | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | rpoE | RNA polymerase (delta subunit); Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling. May function in sigma factor switching. It displaces RNA bound to RNA polymerase in a binary complex; Belongs to the RpoE family. (173 aa) |
| | pta | Phosphotransacetylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (323 aa) |
| | spsL | dTDP-4-deoxyrhamnose-3,5-epimerase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (151 aa) |
| | spsK | Putative dTDP-4-dehydrorhamnose reductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (283 aa) |
| | relQ | (p)ppGpp synthetase; Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. Overexpression in relA mutants (triple relA-yjbM-ywaC deletions and single relA deletions) leads to growth arrest; GTP levels fall drastically, various guanine-related nucleotides are synthesized (ppGp or pGpp), the cellular transcriptional profile changes dramatically and 70S ribosome dimerization occurs. Overexpression in the presence of a wild-type relA gene does not have these effects. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) i [...] (210 aa) |
| | sigY | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB. (178 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | dnaC | Replicative DNA helicase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the helicase family. DnaB subfamily. (454 aa) |
| | yybD | Putative acetyltransferase; Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. (147 aa) |
| | yyaT | Putative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (148 aa) |
