STRINGSTRING
lgt lgt yaaH yaaH gerD gerD cwlJ cwlJ gerKA gerKA gerKC gerKC gerKB gerKB yfkT yfkT yfkR yfkR yhcN yhcN sscA sscA gerPF gerPF gerPE gerPE gerPD gerPD gerPC gerPC gerPB gerPB gerPA gerPA prpE prpE ylaJ ylaJ prkC prkC yndE yndE yndF yndF gerT gerT ypeB ypeB sleB sleB gerM gerM gerE gerE gerAA gerAA gerAB gerAB gerAC gerAC gerBA gerBA gerBB gerBB gerBC gerBC gerQ gerQ ywcE ywcE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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lgtPrelipoprotein diacylglycerol transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. Required for spore germination; Belongs to the Lgt family. (269 aa)
yaaHSpore peptidoglycan hydrolase; N-acetylglucosaminidase involved in cortex peptidoglycan degradation during germination. Cleaves only partially degraded spore peptidoglycans. Recognizes muramic acid delta-lactam residues specific to spore peptidoglycans. (427 aa)
gerDLipoprotein with a role in spores' rapid response to nutrient germinants; May be involved in fructose recognition during germination. (185 aa)
cwlJCell wall hydrolase; Probable spore cortex-lytic enzyme involved in the depolymerization of cortex peptidoglycan during germination. (142 aa)
gerKASpore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the GerABKA family. (544 aa)
gerKCSpore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the GerABKC lipoprotein family. (407 aa)
gerKBSpore germination receptor subunit; Involved in the germination response to the combination of glucose, fructose, L-asparagine, and KCl; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (373 aa)
yfkTPutative spore germination integral inner membrane protein; May be involved in spore germination. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (358 aa)
yfkRPutative spore germination protein; May be involved in spore germination. Belongs to the GerABKC lipoprotein family. (384 aa)
yhcNPutative lipoprotein; Probably contributes, directly or indirectly, to early events in germination. May play a role in spore outgrowth. (189 aa)
sscASpore assembly and germination protein; Spore protein involved in the assembly of several components of the spore coat, including CotB, CotG and CotH, and in spore germination. (28 aa)
gerPFSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (72 aa)
gerPESpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (133 aa)
gerPDSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (58 aa)
gerPCSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (205 aa)
gerPBSpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (77 aa)
gerPASpore germination protein; Required for the formation of functionally normal spores. Could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor. (73 aa)
prpEPhosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase; Asymmetrically hydrolyzes Ap4p to yield AMP and ATP. Does not hydrolyze Ap2a or Ap6A. Also has an ATPase activity. Was shown to dephosphorylate phosphotyrosine but not phosphoserine or phosphothreonine from phosphorylated peptides. Involved in spore germination by controlling expression of genes coding for GerA and GerK receptors. (244 aa)
ylaJPutative lipoprotein; Probably contributes, directly or indirectly, to early events in germination. (209 aa)
prkCProtein kinase; Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act as spore germinants. Autophosphorylates and phosphorylates EF-G (elongation factor G, fusA); the latter modification is likely necessary for germination in response to peptidoglycan. Another group did not detect phosphorylation of EF-G. PrkC is a substrate in vitro of the cotranscribed phosphatase PrpC, which suggests [...] (648 aa)
yndEPutative spore germination integral inner membrane protein; Involved in the germinative response to L-alanine. Could be an amino acid transporter (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. (363 aa)
yndFPutative spore germination lipoprotein; May be involved in spore germination. Belongs to the GerABKC lipoprotein family. (404 aa)
gerTComponent of the spore coat; Involved in spore germination; probably required at the earliest stage of germination. (157 aa)
ypeBSpore membrane component; Required for spore cortex hydrolysis during germination. Appears to be required for either expression, localization, activation or function of SleB. (450 aa)
sleBSpore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components. (305 aa)
gerMGermination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme; Unknown. Affects both sporulation and germination. (366 aa)
gerETranscriptional regulator; Involved in the regulation of spore formation. Directs the transcription of several genes that encode structural components of the protein coat that encases the mature spore (CotB, CotC, CotG, CotS, CotV, CotW, CotX, CotY and CotZ). Controls also the cgeAB and cgeCDE operons. (74 aa)
gerAAComponent of the GerA germination receptor; Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of GerD and GerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (482 aa)
gerABComponent of the germination receptor GerA; Involved in the germinative response to L-alanine. Could be an amino acid transporter. Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (365 aa)
gerACComponent of the germination receptor GerA; Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of GerD and GerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence. (373 aa)
gerBAComponent of germinant receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors respectively). (483 aa)
gerBBComponent of germinant receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Could be an amino acid transporter. Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors, respectively). (368 aa)
gerBCLipoprotein component of the germination receptor B; Involved in the response to the germinative mixture of L- asparagine, glucose, fructose and potassium ions (AGFK). Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors respectively). (374 aa)
gerQInner spore coat protein; Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA. (181 aa)
ywcEProtein required for proper spore morphogenesis and germination; Required for proper spore morphogenesis. Important for spore germination; Belongs to the YwcE family. (87 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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