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alrA alrA gyrB gyrB gyrA gyrA yacD yacD truA truA glmM glmM hxlB hxlB ydaE ydaE topB topB gmuF gmuF purE purE yfhB yfhB gsaB gsaB yhcT yhcT pgcA pgcA prsA prsA yitF yitF yjbO yjbO tenI tenI manA manA uxaC uxaC ykfB ykfB mtnA mtnA mtnW mtnW rluD rluD rpe rpe topA topA truB truB xylA xylA alrB alrB parE parE parC parC galM galM yodA yodA kamA kamA kduI kduI trpF trpF aroH aroH fni fni rluB rluB ppiB ppiB drm drm yrdN yrdN yrpC yrpC yraM yraM hemL hemL tig tig racE racE araD araD araA araA aroX aroX ytzG ytzG menF menF rhaA rhaA rhaU rhaU pgi pgi dhbC dhbC dapF dapF yusQ yusQ pgm pgm tpiA tpiA racX racX mdxM mdxM hisA hisA mnaA mnaA yvyI yvyI rbsD rbsD ywlF ywlF ywhB ywhB bacB bacB galE galE iolI iolI iolB iolB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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alrAD-alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (389 aa)
gyrBDNA gyrase (subunit B); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (638 aa)
gyrADNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (821 aa)
yacDPutative protein secretion PrsA homolog; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. (297 aa)
truAPseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (247 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity). Glucosamine-1-phosphate is used for cell wall biosynthesis (Probable); Belongs to the phosphohexose mutase family. (448 aa)
hxlB6-phospho-3-hexuloisomerase (PHI); Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate. Together with HxlA, may act as a formaldehyde detoxification system. (185 aa)
ydaEConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 10220166; Belongs to the D-lyxose ketol-isomerase family. (167 aa)
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (727 aa)
gmuFPhosphohexomutase; Seems to be involved in the degradation of glucomannan. Belongs to the mannose-6-phosphate isomerase type 1 family. (315 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
yfhBPutative isomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the PhzF family. (293 aa)
gsaBGlutamate-1-semialdehyde aminotransferase, class III aminotransferase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (429 aa)
yhcTPutative RNA pseudouridine synthase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (302 aa)
pgcAAlpha-phosphoglucomutase; Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required fo [...] (581 aa)
prsAMolecular chaperone lipoprotein; Essential protein that plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Has PPIase activity but it is not essential for its function in vivo; Belongs to the PrsA family. (292 aa)
yitFPutative enolase superfamily enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (371 aa)
yjbOPseudouridylate synthase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (283 aa)
tenIThiazole tautomerase; Catalyzes the irreversible aromatization of 2-((2R,5Z)-2- carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate (cThz*-P) to 2- (2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (cThz-P), a step in the biosynthesis of the thiazole phosphate moiety of thiamine. Cannot use cThz* as substrate, indicating that the phosphate group is essential. Has no thiamine phosphate synthase activity, despite a high sequence similarity with ThiE. (205 aa)
manAMannose-6 phosphate isomerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the mannose-6-phosphate isomerase type 1 family. (315 aa)
uxaCGalacturonate isomerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (473 aa)
ykfBL-Ala-D/L-Glu epimerase; Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of the other Ala-X dipeptides L-Ala-L- Asp, L-Ala-L-Leu, L-Ala-L-Met, and L-Ala-L-Ser. Is not able to epimerize other L-Ala-X dipeptides. Is also active with L-Ser-L-Glu and, oddly, L-Pro-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Lys- L-Ala, or D-Ala-D-Ala. (366 aa)
mtnAMethylthioribose-1-phosphate isomerase (methionine salvage pathway); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (353 aa)
mtnW2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase); Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P); Belongs to the RuBisCO large chain family. Type IV subfamily. (405 aa)
rluDPseudouridylate synthase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (303 aa)
rpeRibulose-5-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (691 aa)
truBtRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (309 aa)
xylAXylose isomerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the xylose isomerase family. (445 aa)
alrBAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (394 aa)
parESubunit B of DNA topoisomerase IV; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (655 aa)
parCSubunit A of DNA topoisomerase IV; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (806 aa)
galMAldose 1-epimerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the aldose epimerase family. (325 aa)
yodAPutative tautomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the 4-oxalocrotonate tautomerase family. (129 aa)
kamALysine 2,3-aminomutase; Catalyzes the interconversion of L-alpha-lysine and L-beta- lysine; Belongs to the radical SAM superfamily. KamA family. (471 aa)
kduI4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. (275 aa)
trpFPhosphoribosyl anthranilate isomerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the TrpF family. (215 aa)
aroHChorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (127 aa)
fniIsopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
rluBPseudouridine synthase; Responsible for synthesis of pseudouridine from uracil-2633 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (244 aa)
ppiBPeptidyl-prolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa)
drmPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (394 aa)
yrdNPutative tautomerase; Putative target of GltR. (129 aa)
yrpCGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa)
yraMConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the PrpF family. (367 aa)
hemLGlutamate-1-semialdehyde 2,1-aminotransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (430 aa)
tigProlyl isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily. (424 aa)
racEGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (272 aa)
araDL-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (229 aa)
araAL-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (496 aa)
aroX3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the class-I DAHP synthase family. (358 aa)
ytzGPutative 16S pseudouridylate synthase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (239 aa)
menFMenaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (471 aa)
rhaAL-rhamnose isomerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the rhamnose isomerase family. (424 aa)
rhaUL-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. (104 aa)
pgiGlucose-6-phosphate isomerase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the GPI family. (450 aa)
dhbCIsochorismate synthase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the isochorismate synthase family. (398 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (284 aa)
yusQPutative tautomerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the 4-oxalocrotonate tautomerase family. (127 aa)
pgmPhosphoglycerate mutase; Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. (511 aa)
tpiATriose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
racXAmino acid racemase; Amino-acid racemase able to utilize a broad range of substrates. Preferentially catalyzes the epimerization of LL- diaminopimelate, as well as the racemization of D-lysine, L-arginine, L-ornithine, L-lysine and D-arginine. Has lower activity against D- ornithine, L-histidine, L-alanine, L-tyrosine, L-phenylalanine, L- serine, L-glutamine, L-methionine, L-asparagine and L-homoserine. Has weak activity against L-norleucine, L-aminobutyric acid and L- norvaline. Has no activity toward nine L-amino acids (Thr, Glu, Asp, Val, Leu, Ile, Trp, Cit and Aad). D-amino acids m [...] (227 aa)
mdxMBeta-phosphoglucomutase; Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose (By similarity). (226 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. (245 aa)
mnaAUDP-N-acetylmannosamine 2-epimerase; Catalyzes the conversion of UDP-N-acetylglucosamine into UDP- N-acetylmannosamine, a precursor of the teichoic acid linkage unit. (380 aa)
yvyIPutative phosphohexomutase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e: enzyme; Belongs to the mannose-6-phosphate isomerase type 1 family. (316 aa)
rbsDRibose ABC transporter (membrane bound ribose binding); Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (131 aa)
ywlFRibose 5-phosphate epimerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (149 aa)
ywhB1,3-keto-enol tautomerase; Catalyzes both 1,3- and 1,5-keto-enol tautomerization of the diacid 2-hydroxymuconate (2-hydroxy-2,4-hexadienedioate) to produce 2- oxo-4-hexenedioate. This reaction is highly stereoselective and produces a mixture of stereoisomers, where the (3S)-isomer of 2-oxo-4- hexenedioate predominates. Also catalyzes the tautomerization of 2- hydroxymuconate to 2-oxo-3-hexenedioate, however this reaction is slower and occurs after the tautomerization of 2-hydroxymuconate to 2- oxo-4-hexenedioate. Using 2-hydroxy-2,4-pentadienoate, phenylenolpyruvate, (p-hydroxyphenyl)- [...] (62 aa)
bacBIsomerase component of bacilysin (l-alanine-[2,3-epoxycyclohexano-4]-l-alanine) synthetase; Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins (E/Z ration of 3/1) of the exocyclic-delta(3),delta(5)- dihydro-h [...] (235 aa)
galEUDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). (339 aa)
iolIInosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. (278 aa)
iolB5-deoxy-D-glucuronic acid isomerase; Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate). (271 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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