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yjzB yjzB yaaH yaaH amyE amyE lipC lipC cotP cotP yeeK yeeK yheD yheD yhaX yhaX yhjR yhjR yisY yisY cotZ cotZ cotW cotW cotT cotT yjqC yjqC yknT yknT ylbD ylbD spoVM spoVM spoIIIE spoIIIE cotE cotE ymaG ymaG alrB alrB cotU cotU cotM cotM yoaN yoaN cotD cotD yppG yppG spoIVA spoIVA safA safA spoVID spoVID ysnD ysnD ytxO ytxO cotS cotS tgl tgl yuzC yuzC cotB cotB cotG cotG yxeE yxeE yybI yybI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yjzBConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16391061. (79 aa)
yaaHSpore peptidoglycan hydrolase; N-acetylglucosaminidase involved in cortex peptidoglycan degradation during germination. Cleaves only partially degraded spore peptidoglycans. Recognizes muramic acid delta-lactam residues specific to spore peptidoglycans. (427 aa)
amyEAlpha-amylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 13 family. (659 aa)
lipCSpore coat phospholipase B; Lipase involved in spore germination. Belongs to the 'GDSL' lipolytic enzyme family. (213 aa)
cotPSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (143 aa)
yeeKSpore associated protein; Part of the spore coat. (145 aa)
yheDSpore coat associated protein; Involved in sporulation. (453 aa)
yhaXPutative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (288 aa)
yhjRPutative electron carrier protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc: putative carrier. (145 aa)
yisYPutative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the AB hydrolase superfamily. (268 aa)
cotZSpore coat protein (insoluble fraction, outermost layer); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (148 aa)
cotWSpore coat protein (insoluble fraction); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (105 aa)
cotTSpore coat protein (inner coat); Inner spore coat protein which seems to play a role in germination. (82 aa)
yjqCPutative PBSX phage manganese-containing catalase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin; Belongs to the manganese catalase family. (278 aa)
yknTHypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 15383836, 15743949. (321 aa)
ylbDConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (132 aa)
spoVMFactor required for normal spore cortex and coat synthesis (stage V sporulation); Coordinates cortex and coat assembly during sporulation. Associates with the spore coat protein SpoIVA and with the outer forespore membrane, thereby serving as a membrane anchor that tethers SpoIVA and the entire spore coat to the forespore surface. May also serve as a competitive inhibitor of FtsH activity during sporulation. (26 aa)
spoIIIESpore DNA translocase; Plays an essential role during sporulation. Required for the translocation of the chromosomal DNA from mother cell into the forespore during polar septation, for the final steps of compartmentalization in the presence of trapped DNA, and for the final steps of engulfment. The N-terminus mediates localization to the division septum and is required for both septal membrane fusion and engulfment membrane fusion. May form DNA-conducting channels across the two lipid bilayers of the septum after cell division. The C-terminus functions as a DNA motor that exports DNA i [...] (787 aa)
cotEMorphogenic spore protein; Morphogenic protein required for the assembly of the outer coat of the endospore. Is also a regulatory protein for the expression of cotA, cotB, cotC, cotH and other genes encoding spore outer coat proteins. (181 aa)
ymaGInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (91 aa)
alrBAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (394 aa)
cotUSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (86 aa)
cotMSpore coat protein (outer); Involved in spore outer coat assembly. May be part of a cross-linked insoluble skeleton that surrounds the spore, serves as a matrix for the assembly of additional outer coat material, and confers structural stability to the final structure. (130 aa)
yoaNOxalate decarboxylase; Converts oxalate to formate and CO(2); To B.subtilis OxdC. (392 aa)
cotDSpore coat protein (inner); Evidence 1a: Function experimentally demonstrated in the studied strain; cell process. (75 aa)
yppGConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (125 aa)
spoIVAMorphogenetic stage IV sporulation protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM. (492 aa)
safAMorphogenetic protein associated with SpoVID; Probably involved in the assembly of some coat protein components implicated in both lysozyme resistance and germination. Could be required for the assembly of CotG. Associates with SpoIVD during the early stage of coat assembly. (387 aa)
spoVIDMorphogenetic spore protein (stage VI sporulation); Required for assembly of a normal spore coat. May be a component of the innermost layer of the spore coat that aids in its adherence to the prespore. (575 aa)
ysnDInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (111 aa)
ytxOOuter spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (143 aa)
cotSSpore coat protein; Seems to be required for the assembly of the CotSA protein in spores. (351 aa)
tglProtein-glutamine gamma-glutamyltransferase (transglutaminase); Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links. In wild-type spores at 37 degrees Celsius, tgl mediates the cross-linking of GerQ in higher molecular mass forms, probably in cooperation with YabG; Belongs to the bacillus TGase family. (245 aa)
yuzCInner spore coat protein; Evidence 2b: Function of strongly homologous gene; Product type cp: cell process. (122 aa)
cotBSpore coat protein (outer); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (380 aa)
cotGSpore morphogenetic protein; May be a morphogenetic protein that is required for the incorporation of protein CotB into the spore coat. (195 aa)
yxeEInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (121 aa)
yybIInner spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (262 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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