STRINGSTRING
polC polC yddF yddF yddG yddG rapI rapI phrI phrI yddM yddM pcrB pcrB pcrA pcrA ligA ligA yerH yerH yddD yddD recA recA dnaI dnaI dnaB dnaB thrC thrC ganA ganA ssbB ssbB dnaC dnaC yybS yybS cotF cotF ssbA ssbA rpsF rpsF immR immR ydbT ydbT amyE amyE recF recF dnaN dnaN sacV sacV ydcQ ydcQ ydcR ydcR ydcS ydcS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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polCDNA polymerase III (alpha subunit); Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity; Belongs to the DNA polymerase type-C family. PolC subfamily. (1437 aa)
yddFConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (108 aa)
yddGConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (815 aa)
rapIResponse regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator; Belongs to the RAP family. (391 aa)
phrISecreted regulator of the activity of phosphatase RapI; Inhibitor of the activity of phosphatase RapI. (39 aa)
yddMPutative helicase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (313 aa)
pcrBHeptaprenylglyceryl-phosphate synthase; Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond- formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Ca [...] (228 aa)
pcrAATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. (739 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (668 aa)
yerHPutative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. (396 aa)
yddDHypothetical protein; Evidence 5: No homology to any previously reported sequences. (174 aa)
recAMultifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] (348 aa)
dnaIHelicase loader; Probably involved in DNA replication. (311 aa)
dnaBHelicase loading protein; Probable component of primosome involved in the initiation of DNA replication. It is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110. (472 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
ganAArabinogalactan type I oligomer exo-hydrolase (beta-galactosidase, lactase); Hydrolyzes oligosaccharides released by the endo-1,4-beta- galactosidase GalA from arabinogalactan type I, a pectic plant polysaccharide. It is unable to use lactose as a sole carbon source. Maximal activity with o-nitrophenyl-beta-D-galactopyranoside (ONPG) and p-nitrophenyl-beta-D-galactopyranoside (PNPG) as substrates, trace activity with p-nitrophenyl-alpha-L-arabinopyranoside and o- nitrophenyl-beta-D-fucopyranoside as substrates, but no activity with p-nitrophenyl-alpha-D-galactopyranoside, p-nitrophenyl [...] (687 aa)
ssbBSingle-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange. (113 aa)
dnaCReplicative DNA helicase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the helicase family. DnaB subfamily. (454 aa)
yybSPutative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (309 aa)
cotFSpore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type s: structure. (160 aa)
ssbASingle-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Has a 20-fold higher affinity for ssDNA than SsbB; SsbA and DprA activate the homologuos DNA strand exchange function of RecA-ATP. (172 aa)
rpsFRibosomal protein S6 (BS9); Binds together with S18 to 16S ribosomal RNA. (95 aa)
immRPhage element (ICEBs1)transcriptional regulator (Xre family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type h: extrachromosomal origin. (127 aa)
ydbTConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (493 aa)
amyEAlpha-amylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 13 family. (659 aa)
recFDNA repair and genetic recombination factor; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. Is recruited to repair centers, foci that are the site of double- strand DNA break(s) after RecN and RecO; recruitment may depend on RecO. (370 aa)
dnaNDNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] (378 aa)
sacVTranscriptional regulator; Required for the excision of the integrative and conjugative element ICEBs1. Excision of ICEBs1 requires two sites, attL and attR, at the left and right ends of the integrated ICEBs1. (64 aa)
ydcQPutative DNA wielding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (480 aa)
ydcRPutative replication protein; Probable DNA relaxase involved in the transfer of the integrative and conjugative element ICEBs1. Required for the transfer of ICEBs1. Probably mediates conjugation of ICEBs1 by nicking at oriT on the conjugative element and facilitates the translocation of a single strand of ICEBs1 DNA through a transmembrane conjugation pore into the recipient cell; Belongs to the plasmid replication initiation factor family. (352 aa)
ydcSConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (89 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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