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yjbI yjbI mhqA mhqA mhqR mhqR clpE clpE ykvZ ykvZ ykuU ykuU panE-2 panE-2 bshC bshC ymaD ymaD yndB yndB bshBB bshBB arxR arxR ypiA ypiA resD resD yqkF yqkF yqiG yqiG mgsR mgsR arsC arsC yrhC yrhC mtnN mtnN cymR cymR clpX clpX trxA trxA ytsP ytsP rpsD rpsD ccpA ccpA mrgA mrgA yvgN yvgN pnbA pnbA clpP clpP trxB trxB nagR nagR hemQ hemQ nfrAA nfrAA cysK cysK yraA yraA ctsR ctsR mcsA mcsA mcsB mcsB clpC clpC rpoB rpoB rpoA rpoA ycbG ycbG yceK yceK hxlR hxlR yczG yczG ydhJ ydhJ yerO yerO yezD yezD treR treR perR perR citR citR cueR cueR yizD yizD yjbH yjbH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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yjbIPutative thiol management oxidoreductase component; Hemoglobin-like protein that exhibits a low peroxidase activity. Its very high oxygen affinity may rule out the possibility that it is involved in oxygen transport. (132 aa)
mhqAPutative hydroquinone-specific extradiol dioxygenase; Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds. (316 aa)
mhqRTranscriptional regulator (MarR family); Negatively regulates mhqA, mhqED, mhqNOP, and azoR2 which may contribute to the degradation of aromatic compounds. (145 aa)
clpEATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. (699 aa)
ykvZPutative transcriptional regulator (LacI family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (321 aa)
ykuUPutative 2-cys peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (180 aa)
panE-22-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (298 aa)
bshCMalate glucosamine cysteine ligase; Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH. (539 aa)
ymaDPutative peroxiredoxin-related protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the OsmC/Ohr family. (150 aa)
yndBPutative stress-related ATPase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the AHA1 family. (144 aa)
bshBBMalate N-acetylglucosamine deacetylase (second enzyme); Involved in bacillithiol (BSH) biosynthesis. Catalyzes the second step of the pathway, the deacetylation of N- acetylglucosaminylmalate (GlcNAc-Mal) to glucosamine malate (GlcN-Mal). Belongs to the PIGL family. (221 aa)
arxRTranscriptional repressor; Negatively regulates yodC and azoR1 which may contribute to the degradation of aromatic compounds. Probably positively regulates the catechol-specific transcription of mhqNOP, mhqED, and mhqA. (112 aa)
ypiAConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (423 aa)
resDTwo-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa)
yqkFNADPH-dependent aldo-keto reductase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. (306 aa)
yqiGPutative NADH-dependent flavin oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. (372 aa)
mgsRTranscriptional regulator of stress; Regulates transcription of a subregulon within the general stress response. Exerts positive and negative effects in response to ethanol stress. (126 aa)
arsCThioredoxin-coupled arsenate reductase; Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. In vitro, can dephosphorylate para- nitrophenyl phosphate (pNPP). Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily. (139 aa)
yrhCConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 17056751. (76 aa)
mtnNMethylthioadenosine / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
cymRTranscriptional regulator of cysteine biosynthesis; Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the Cy [...] (138 aa)
clpXProtein unfolding ATPase required for presentation of proteins to proteases; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Probably the major protease that degrades proteins tagged by trans-translation. (420 aa)
trxAThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (104 aa)
ytsPConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the free Met sulfoxide reductase family. (163 aa)
rpsDRibosomal protein S4 (BS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. S4 represses its own expression; it is not know if this is at the level of translation or of mRNA stability; Belongs to the universal ribosomal protein uS4 family. (200 aa)
ccpATranscriptional regulator (Lacl family); Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P- Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons. (334 aa)
mrgAMetalloregulation DNA-binding stress protein; Forms highly stable, multimeric protein-DNA complexes which accumulate in stationary-phase cells and protect against oxidative killing; Belongs to the Dps family. (153 aa)
yvgNGlyoxal/methylglyoxal reductase; Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis; Belongs to the aldo/keto reductase family. (276 aa)
pnbAPara-nitrobenzyl esterase (intracellular esterase B); Catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol; Belongs to the type-B carboxylesterase/lipase family. (489 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a limited peptidase activity in the absence of ATP-binding subunits ClpC, ClpE or ClpX. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcriptional activation of genes under the control of the sigma-W factor. Probably the major protease that degrades prot [...] (197 aa)
trxBThioredoxin reductase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (316 aa)
nagRTranscriptional regulator (GntR family); Main transcriptional repressor of genes involved in N- acetylglucosamine (GlcNAc) transport and utilization. Represses the expression of the nagAB and nagP operons by binding directly within their upstream regions. Binds to the DNA consensus sequence 5'-ATTGGTATAGACAACT-3'. Also acts as a weak repressor of mapB expression. (243 aa)
hemQEssential component of heme biosynthesis; May function as heme-dependent peroxidase. (254 aa)
nfrAAFMN-containing NADPH-linked nitro/flavin reductase; Reduces FMNH(2) to FMN, with NADPH as reductant. It also reduces nitroaromatic compounds, quinones and azo dyes. (249 aa)
cysKCysteine synthase; Catalyzes the conversion of O-acetylserine to cysteine. Also acts as a sensor of cysteine availability in the signal transduction pathway modulating CymR activity. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR- CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression. (308 aa)
yraAGeneral stress protein; Functions in the protection against aldehyde-stress, possibly by degrading damaged proteins. (169 aa)
ctsRTranscriptional regulator; Controls the expression of the cellular protein quality control genes clpC, clpE and clpP, as well as mcsA and mcsB. Acts as a repressor of these class III stress genes by binding to a directly repeated heptanucleotide operator sequence (A/GGTCAAA NAN A/GGTCAAA). After heat shock, CtsR is degraded by the ClpCP and ClpEP proteolytic systems, ensuring the derepression of clpE, clpP and the clpC operon. CtsR negatively autoregulates its own synthesis. (154 aa)
mcsAActivator of protein kinase McsB; Activates the phosphorylation activity of the protein- arginine kinase McsB. Is required for the delocalization of competence proteins from the cell poles. (185 aa)
mcsBProtein tyrosine kinase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system, where it is involved in regulating the global heat shock repressor CtsR; phosphorylates arginine residues in the winged helix- turn-helix domain of CtsR, thereby preventing its binding to DNA and consequently inducing the expression of repressed genes. The transcriptional repressor HrcA, the chaperone GroEL, the unfoldase ClpC, together with several ribosomal subunits, represent other physiological targets of McsB under str [...] (363 aa)
clpCClass III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. (810 aa)
rpoBRNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1193 aa)
rpoARNA polymerase (alpha subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa)
ycbGTranscriptional regulator (GntR family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator. (233 aa)
yceKPutative transcriptional regulator (ArsR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (100 aa)
hxlRPositive regulator of hxlAB expression; Positive regulator of hxlAB expression. (120 aa)
yczGPutative transcriptional regulator (ArsR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (104 aa)
ydhJPutative metal-dependent phosphohydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (325 aa)
yerOPutative transcriptional regulator (TetR/AcrR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (289 aa)
yezDPutative paralog of RsbR; Evidence 7: Gene remnant; Product type pr: putative regulator. (55 aa)
treRTranscriptional regulator (GntR family); Repressor for the trePA operon. It is able to bind trehalose- 6-phosphate. (238 aa)
perRTranscriptional regulator (Fur family); Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA; Belongs to the Fur family. (145 aa)
citRTranscriptional regulator CitR (LysR family); Negative regulatory protein for the citA gene for citrate synthase I; Belongs to the LysR transcriptional regulatory family. (291 aa)
cueRCopper efflux transcriptional regulator; Transcriptional activator of the copZA operon. (143 aa)
yizDConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (55 aa)
yjbHPutative thiol management oxidoreductase component; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (299 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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