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yebD yebD aprE aprE comK comK yjlC yjlC ctaD ctaD hfq hfq bsrG bsrG resE resE resD resD resA resA txpA txpA gerE gerE ywcJ ywcJ yxiE yxiE ldh ldh lctP lctP nasE nasE nasD nasD ydbL ydbL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yebDHypothetical protein; Evidence 5: No homology to any previously reported sequences. (55 aa)
aprESerine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. (381 aa)
comKCompetence transcription factor (CTF); A master regulator required for the expression of late competence genes including comC, comE, comG and the bdbDC operon. Receives signals from SrfA, and possibly other regulatory COM genes, and transduces these signals to the late COM genes. Represses transcription of rok. May repress expression of a few genes. (192 aa)
yjlCConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 17015645. (140 aa)
ctaDCytochrome caa3 oxidase (subunit I); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. (622 aa)
hfqHfq RNA chaperone; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (73 aa)
bsrGPhage toxin; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. (38 aa)
resETwo-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. (589 aa)
resDTwo-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. (240 aa)
resAExtracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein); Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation. Belongs to the thioredoxin family. ResA subfamily. (179 aa)
txpAConserved unknown protein (fragment); Toxic component of a type I toxin-antitoxin (TA) system. Overexpression of txpA causes cell lysis; the TxpA protein has been suggested to act on the cell membrane or might possibly block cell wall synthesis. Overexpression in E.coli is not toxic. (59 aa)
gerETranscriptional regulator; Involved in the regulation of spore formation. Directs the transcription of several genes that encode structural components of the protein coat that encases the mature spore (CotB, CotC, CotG, CotS, CotV, CotW, CotX, CotY and CotZ). Controls also the cgeAB and cgeCDE operons. (74 aa)
ywcJFormate/nitrite transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type t: transporter. (256 aa)
yxiEPhosphate starvation protein (universal stress protein A family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor; Belongs to the universal stress protein A family. (148 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (321 aa)
lctPL-lactate permease; May play a role in L-lactate transport. (541 aa)
nasEAssimilatory nitrite reductase subunit; Required for nitrite assimilation. Required for activity of the reductase (By similarity). (106 aa)
nasDAssimilatory nitrite reductase subunit; Required for nitrite assimilation. (805 aa)
ydbLConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (111 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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