| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bslA | epsA | BSU31080 | BSU34370 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | 0.925 |
| bslA | kinB | BSU31080 | BSU31450 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | 0.561 |
| bslA | kinC | BSU31080 | BSU14490 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A. | 0.690 |
| bslA | kinD | BSU31080 | BSU13660 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | 0.681 |
| bslA | spo0A | BSU31080 | BSU24220 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box). | 0.850 |
| bslA | tapA | BSU31080 | BSU24640 | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. | 0.987 |
| epsA | bslA | BSU34370 | BSU31080 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | 0.925 |
| epsA | kinB | BSU34370 | BSU31450 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | 0.688 |
| epsA | kinC | BSU34370 | BSU14490 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A. | 0.848 |
| epsA | kinD | BSU34370 | BSU13660 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | 0.845 |
| epsA | kinE | BSU34370 | BSU13530 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. | 0.488 |
| epsA | spo0A | BSU34370 | BSU24220 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box). | 0.919 |
| epsA | tapA | BSU34370 | BSU24640 | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. | 0.994 |
| kinB | bslA | BSU31450 | BSU31080 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Biofilm hydrophobic layer component; Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. | 0.561 |
| kinB | epsA | BSU31450 | BSU34370 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. | 0.688 |
| kinB | kinC | BSU31450 | BSU14490 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A. | 0.722 |
| kinB | kinD | BSU31450 | BSU13660 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Histidine kinase phosphorylating Spo0A; Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions. | 0.738 |
| kinB | kinE | BSU31450 | BSU13530 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory protein spo0A under biofilm growth conditions. Also able to weakly phosphorylate spo0F. | 0.699 |
| kinB | spo0A | BSU31450 | BSU24220 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box). | 0.976 |
| kinB | tapA | BSU31450 | BSU24640 | Two-component sensor histidine kinase; Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity. | Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. | 0.759 |