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ytrP ytrP comP comP comQ comQ araE araE ykoW ykoW yjcA yjcA relP relP yhcK yhcK yfiZ yfiZ rpoB rpoB fliI fliI fliY fliY cheY cheY cinA cinA uvrX uvrX spoIIP spoIIP icd icd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ytrPPutative diguanylate cyclase-related enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (579 aa)
comPTwo-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation. (769 aa)
comQIsoprenyl transferase (pre-ComX modification); Involved in the maturation of ComX, part of a major quorum- sensing system that regulates the development of genetic competence. (299 aa)
araEArabinose-related compounds permease; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). (464 aa)
ykoWPutative sensor diguanylate cyclase; Probable signaling protein whose physiological role is not yet known. (800 aa)
yjcASporulation-specific protein; Involved in sporulation. (118 aa)
relP(p)ppGpp synthetase; Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The enzyme binds ATP, then GDP or GTP and catalysis is highly cooperative. In eubacteria ppGpp (guanosine 3'- diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Probably has a minor role in the stringent response ; Belongs to the RelA/SpoT family. (211 aa)
yhcKPutative diguanylate cyclase or phosphodiesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (359 aa)
yfiZiron(III) siderophore transport permease; Part of the ABC transporter complex YfiYZ/YfhA/YusV involved in import of the iron-hydroxamate siderophores schizokinen, arthrobactin and corprogen. (333 aa)
rpoBRNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1193 aa)
fliIFlagellar-specific ATPase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. (438 aa)
fliYFlagellar motor switching and energizing phosphatase; Component of the flagellar switch. Binds CheY-P and increases its hydrolysis rate in vitro. May function constitutively to remove CheY-P around the flagellar switch to maintain an optimal level of CheY-P whereas CheC may function after addition of an attractant to cope with increased levels of CheY-P; Belongs to the FliN/MopA/SpaO family. (378 aa)
cheYRegulator of chemotaxis and motility; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. (120 aa)
cinACompetence-damage inducible regulator; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CinA family. (416 aa)
uvrXLesion bypass phage DNA polymerase; Evidence 2b: Function of strongly homologous gene; enzyme. (416 aa)
spoIIPSpore autolysin (stage II sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process. (401 aa)
icdIsocitrate dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (423 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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