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capA capA feuC feuC feuB feuB feuA feuA ybgA ybgA acpA acpA yngB yngB bceB bceB bceA bceA ytdA ytdA epsD epsD epsC epsC gtaB gtaB pgdS pgdS capE capE capC capC capB capB ywrD ywrD ywqF ywqF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
capACapsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. (380 aa)
feuCIron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. (336 aa)
feuBIron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. (334 aa)
feuAIron hydroxamate-binding lipoprotein; Involved in the uptake of iron. Belongs to the bacterial solute-binding protein 8 family. (317 aa)
ybgAPutative transcriptional regulator (GntR family); Transcriptional repressor of genes involved in glucosamine transport and utilization. Represses the expression of the gamAP operon by binding to the gamA-gamR intergenic region. (235 aa)
acpAAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa)
yngBPutative UTP-glucose-1-phosphate uridylyltransferase; Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG) (By similarity). (297 aa)
bceBABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family. (646 aa)
bceABacitracin ABC efflux transporter (ATP-binding protein); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export. Responsible for energy coupling to the transport system. (253 aa)
ytdAPutative UTP-glucose-1-phosphate uridylyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (272 aa)
epsDPutative extracellular matrix biosynthesis enzyme; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (381 aa)
epsCPutative UDP-sugar epimerase; Involved in biofilm formation; Belongs to the polysaccharide synthase family. (598 aa)
gtaBUTP-glucose-1-phosphate uridylyltransferase; Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since UDP-glucose serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely d [...] (292 aa)
pgdSgamma-DD-glutamyl hydrolase (PGA depolymerase); Cleaves, in an endo-type manner, the gamma-glutamyl bond between D-glutamate and L-glutamate of poly-gamma-glutamate (PGA). (413 aa)
capEFactor required for polyglutamate synthesis; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (55 aa)
capCCapsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. (149 aa)
capBCapsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. (393 aa)
ywrDPutative enzyme; Overexpressed protein with an N-terminal His tag has been reported not to hydrolyze glutathione; it is not clear if the construct is processed to 2 subunits. (525 aa)
ywqFUDP-glucose dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (440 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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