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gltT gltT ykbA ykbA yloU yloU yloV yloV sdaAB sdaAB sdaAA sdaAA dapG dapG alsT alsT yodF yodF ilvA ilvA thyB thyB aapA aapA lysC lysC ysaA ysaA yuiF yuiF thrB thrB thrC thrC glpQA glpQA yutH yutH lysP lysP yvbW yvbW ybeC ybeC yabJ yabJ hom hom ybgF ybgF amyE amyE yclM yclM ydaO ydaO ydgF ydgF yecA yecA bcaP bcaP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gltTProton/sodium-glutamate symport protein; This carrier protein is part of the Na(+)-dependent, binding- protein-independent glutamate-aspartate transport system. (429 aa)
ykbAPutative amino acid permease; Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids. (438 aa)
yloUConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16014871, 17114254; Belongs to the asp23 family. (120 aa)
yloVPutative dihydroxyacetone/glyceraldehyde kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (553 aa)
sdaABL-serine dehydratase (beta chain); Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa)
sdaAAL-serine dehydratase (alpha chain); Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (300 aa)
dapGAspartokinase I (alpha and beta subunits); Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. Belongs to the aspartokinase family. (404 aa)
alsTAmino acid carrier protein; Evidence 2b: Function of strongly homologous gene; Product type t: transporter; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. (465 aa)
yodFPutative Na+/metabolite permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (422 aa)
thyBThymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
aapAd-Serine/d-alanine/glycine permease; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (462 aa)
lysCAspartokinase II alpha subunit (aa 1->408) and beta subunit (aa 246->408); Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. (408 aa)
ysaAPutative phosphatase; Catalyzes the last step of the phosphorylated serine biosynthetic pathway, i.e. dephosphorylation of O-phospho-L-serine to form L-serine. To a lesser extent, is also able to dephosphorylate phosphothreonine, phosphoethanolamine, and histidinol phosphate in vitro; Belongs to the HAD-like hydrolase superfamily. (260 aa)
yuiFAmino acid transporter; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. (442 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
glpQAGlycerophosphoryl diester phosphodiesterase; Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. (293 aa)
yutHSpore coat-associated protein; Involved in sporulation; Belongs to the CotS family. (339 aa)
lysPLysine permease; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (469 aa)
yvbWPutative leucine permease; May participate in leucine metabolism. May transport leucine or a compound related to leucine metabolism; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (447 aa)
ybeCPutative H+/amino acid transporter; Uptake of an yet unknown amino-acid with the concomitant import of a proton; Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family. (539 aa)
yabJAminoacrylate/iminopropionate hydrolase/deaminase; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis. May have a role in the purine metabolism; Belongs to the RutC family. (125 aa)
homHomoserine dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (433 aa)
ybgFPutative aminoacid permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (470 aa)
amyEAlpha-amylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 13 family. (659 aa)
yclMAspartate kinase III; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. (454 aa)
ydaOPutative metabolite transporter; High-affinity potassium transporter. (607 aa)
ydgFPutative amino acid permease; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (458 aa)
yecAPutative amino acid/polyamine permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (424 aa)
bcaPBranched-chain amino acid transporter; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (465 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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