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| | ykgA | Putative aminohydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the DDAH family. (286 aa) |
| | yaaI | Putative isochorismatase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the isochorismatase family. (181 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | purR | Transcriptional regulator of the purine biosynthesis operon; Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (285 aa) |
| | ctc | Ribosomal protein Ctc, binding 5S RNA; Not required for exponential growth; probably functions in vegetatively growing cells, maybe required for accurate translation under stress conditions. (204 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (188 aa) |
| | ctsR | Transcriptional regulator; Controls the expression of the cellular protein quality control genes clpC, clpE and clpP, as well as mcsA and mcsB. Acts as a repressor of these class III stress genes by binding to a directly repeated heptanucleotide operator sequence (A/GGTCAAA NAN A/GGTCAAA). After heat shock, CtsR is degraded by the ClpCP and ClpEP proteolytic systems, ensuring the derepression of clpE, clpP and the clpC operon. CtsR negatively autoregulates its own synthesis. (154 aa) |
| | mcsA | Activator of protein kinase McsB; Activates the phosphorylation activity of the protein- arginine kinase McsB. Is required for the delocalization of competence proteins from the cell poles. (185 aa) |
| | mcsB | Protein tyrosine kinase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system, where it is involved in regulating the global heat shock repressor CtsR; phosphorylates arginine residues in the winged helix- turn-helix domain of CtsR, thereby preventing its binding to DNA and consequently inducing the expression of repressed genes. The transcriptional repressor HrcA, the chaperone GroEL, the unfoldase ClpC, together with several ribosomal subunits, represent other physiological targets of McsB under str [...] (363 aa) |
| | clpC | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. (810 aa) |
| | radA | DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (458 aa) |
| | sigH | RNA polymerase sigma-30 factor (sigma(H)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in the transition to post- exponential phase in the beginning of sporulation. It is also required for transcription of several stationary phase genes. (218 aa) |
| | sigW | RNA polymerase ECF(extracytoplasmic function)-type sigma factor W; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-W controls genes involved in response to cell envelope stress such as antimicrobial peptides , alkaline pH , transport processes and detoxification. (187 aa) |
| | cypC | Fatty acid beta-hydroxylating cytochrome P450; Catalyzes the alpha- and beta-hydroxylation of myristic acid in the presence of hydrogen peroxide; Belongs to the cytochrome P450 family. (417 aa) |
| | ybyB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (86 aa) |
| | ycbP | Putative inner integral membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (128 aa) |
| | ycdF | Putative glucose 1-dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa) |
| | ycdG | Putative oligo-carbohydrate hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (561 aa) |
| | nadE | Ammonium-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (272 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase; Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate. (462 aa) |
| | yczO | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (54 aa) |
| | ydaC | Putative methyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the methyltransferase superfamily. (181 aa) |
| | ydaD | Putative dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (286 aa) |
| | ydaE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 10220166; Belongs to the D-lyxose ketol-isomerase family. (167 aa) |
| | ydaG | Putative general stress protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (140 aa) |
| | ydaJ | Putative glycosyl hydrolase lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein. (362 aa) |
| | ydaK | Putative membrane protein with diguanylate cyclase domain; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (283 aa) |
| | ydaL | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (569 aa) |
| | ydaM | Putative glycosyltransferase associated to biofilm formation; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (420 aa) |
| | ydaN | Putative regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator. (703 aa) |
| | ydaP | Putative enzyme with pyruvate as substrate; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (574 aa) |
| | ydaS | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (85 aa) |
| | ydaT | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (150 aa) |
| | ydbD | Putative manganese-containing catalase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the manganese catalase family. (273 aa) |
| | rsbU | Serine phosphatase; Positive regulator of sigma-B activity. Dephosphorylates RsbV in response to environmental stress conveyed from the RsbXST module. (335 aa) |
| | rsbV | Anti-anti-sigma factor (antagonist of RsbW); Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B. (109 aa) |
| | rsbW | Switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein); Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (160 aa) |
| | sigB | RNA polymerase sigma-37 factor (sigma(B)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation. May play a role in the ability of the bacterium to adapt to various stresses but is not essential for its survival under these conditions. Positively regulates expression of its own operon; Belongs to the sigma-70 fac [...] (262 aa) |
| | rsbX | Serine phosphatase; Negative regulator of sigma-B activity. Dephosphorylates RsbS. Plays a role both in maintaining low sigma-B activity during growth and in reestablishing prestress sigma-B activity after induction. Could have a negative feedback role by indirectly communicating sigma-B protein levels. (199 aa) |
| | ydfO | Putative dioxygenase; Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds. (312 aa) |
| | ydjJ | Putative membrane associated potassium channel; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (341 aa) |
| | yebE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (184 aa) |
| | yebG | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (65 aa) |
| | yerD | Putative flavoenzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (525 aa) |
| | opuE | Proline transporter; Catalyzes the uptake of extracellular proline under high- osmolarity growth conditions. Essential for the use of proline present in the environment as an osmoprotectant. (492 aa) |
| | cypD | Putative bifunctional P-450/NADPH-P450 reductase 1; Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of a range of long-chain fatty acids, with a preference for long-chain unsaturated and branched-chain fatty acids over saturated fatty acids. Hydroxylation of myristic acid occurs mainly at the omega-2 position. Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain. Is also able to catalyze efficient oxidation of sodium dodecyl sulfate (SDS). (1061 aa) |
| | yflT | Heat stress induced protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (115 aa) |
| | yflD | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (45 aa) |
| | yflA | Putative aminoacid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (471 aa) |
| | yfkM | General stress protein 18; Functions in the protection against aldehyde-stress, possibly by degrading damaged proteins. (172 aa) |
| | yfhD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (63 aa) |
| | yfhE | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (36 aa) |
| | yfhF | Putative nucleotide binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. (303 aa) |
| | yfhK | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (172 aa) |
| | csbB | Putative glycosyl transferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glycosyltransferase 2 family. GtrB subfamily. (329 aa) |
| | yfhO | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (861 aa) |
| | yhbJ | Putative integral membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (221 aa) |
| | yhcA | Putative exporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (532 aa) |
| | yhcC | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (124 aa) |
| | yhcM | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (151 aa) |
| | pgcA | Alpha-phosphoglucomutase; Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required fo [...] (581 aa) |
| | yhdF | Putative NAD(P)-dependent dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (289 aa) |
| | yhdH | Putative sodium-dependent transporter; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (451 aa) |
| | sigM | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (YhdL) until released. This sigma factor is involved in the maintenance of membrane and cell wall integrity in response to environmental stresses including salt, acid, ethanol and antibiotics stress. Partially regulates transcription from a number of genes including disA. (163 aa) |
| | yhdN | Aldo/keto reductase specific for NADPH; Aldo-keto reductase (AKR) that displays broad substrate specificity in vitro. Is able to reduce the standard AKR substrates DL- glyceraldehyde, D-erythrose, methylglyoxal, p-nitrobenzaldehyde, benzaldehyde and butyraldehyde, in the presence of NADPH. Cannot use NADH as a cosubstrate. Does not act on glucose, 2-pyridine carboxyaldehyde, fructose and xylose. The physiological function of this enzyme is not clear. May play a role in bacterial stress response and/or in detoxification of reactive aldehydes. Belongs to the aldo/keto reductase family. A [...] (331 aa) |
| | nhaC | Na+/H+ antiporter; Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system. (453 aa) |
| | nhaX | Stress response protein, UspA family; Evidence 2b: Function of strongly homologous gene; factor. (166 aa) |
| | yhgE | Putative methyl-accepting protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (775 aa) |
| | yhfI | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (244 aa) |
| | yhxD | Putative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (299 aa) |
| | yitT | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (280 aa) |
| | yjzE | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11976315. (84 aa) |
| | yjgB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 1580552. (191 aa) |
| | yjgC | Putative formate dehydrogenase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (985 aa) |
| | yjgD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (186 aa) |
| | yjlB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 10704478. (165 aa) |
| | ohrB | Organic hydroperoxide resistance reductase B; Involved in organic hydroperoxide resistance. Belongs to the OsmC/Ohr family. (136 aa) |
| | ykzN | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (56 aa) |
| | sigI | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of cell wall metabolism in response to heat stress. Acts by regulating the expression of genes such as bcrC, mreBH and lytE. Also plays a role in survival at low temperatures. Belongs to the sigma-70 factor family. SigI subfamily. (251 aa) |
| | spo0E | Negative regulatory phosphatase acting on Spo0A-P (sporulation); Aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation. Belongs to the spo0E family. (85 aa) |
| | ykuT | Putative small-conductance mechanosensitive channel; May play a role in resistance to osmotic downshock. Belongs to the MscS (TC 1.A.23) family. (267 aa) |
| | sigG | RNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes in the forespore. (260 aa) |
| | cpgA | GTPase involved in ribosome and sacculus morphogenesis; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase with a low level of activity and slow catalytic turnover, does not act on ATP. GTPase activity is stimulated by the presence of 30S or 70S ribosomes, phosphorylation increases stimulation. Depletion results in increased sensitivity to protein synthesis inhibitors that block the [...] (298 aa) |
| | rpe | Ribulose-5-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa) |
| | sigD | RNA polymerase sigma-28 factor (sigma-D); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This alternative sigma factor is required for the transcription of the flagellin and motility genes as well as for wild- type chemotaxis. (254 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (260 aa) |
| | infB | Initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (716 aa) |
| | ylxP | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (92 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (117 aa) |
| | truB | tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (309 aa) |
| | rpsO | Ribosomal protein S15 (BS18); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | pnpA | Polynucleotide phosphorylase (PNPase); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. Necessary for competence development in Bacillus subtilis. May be necessary for modification of the srfA transcript (stabilization or translation activation). (705 aa) |
| | ymaE | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (274 aa) |
| | yoxC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (101 aa) |
| | yoxB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (256 aa) |
| | yoaA | Putative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the acetyltransferase family. (177 aa) |
| | xynA | Endo-1,4-beta-xylanase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 11 (cellulase G) family. (213 aa) |
| | yozB | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (178 aa) |
| | yocB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (260 aa) |
| | rtbJ | Antitoxin of ribonuclease RttI; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. Confers resistance to catechol, 2- methylhydroquinone (2-MHQ), and diamide. Probably could also reduce benzoquinones produce by the auto-oxidation of catechol and 2- methylhydroquinone. (208 aa) |
| | yocK | Putative general stress protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (163 aa) |
| | yojJ | Putative enzyme with DAC domain; One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di- AMP synthesis. Overexpression of the hyperactive mutant (L44F) in the absence of c-di-AMP phosphodiesterase GdpP leads to growth defects in log phase (long curly cell filaments) that disappear upon sporulation; spore formation is normal, showing sporulation is insensitive to the excess c-di-AMP. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...] (207 aa) |
| | yorA | Putative capsid component; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps: putative structure. (586 aa) |
| | sigX | RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. May be involved in the regulation of iron metabolism; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | ypuD | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (114 aa) |
| | ypuB | Hypothetical protein; Evidence 7: Gene remnant; PubMedId: 15849754, 16850406. (67 aa) |
| | sigF | RNA polymerase sporulation-specific sigma factor (sigma-F); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. Interaction with SpoIIAB inhibits sigma-F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. Responsible for expression of csfB (the anti-sigma-G factor Gin). (255 aa) |
| | yqjL | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (253 aa) |
| | yqjF | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (242 aa) |
| | bmrU | Putative lipid kinase BmrU; May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG). In fact, is not able to exhibit diacylglycerol kinase activity in vitro. (297 aa) |
| | yqhY | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16014871, 17114254; Belongs to the asp23 family. (135 aa) |
| | yqxL | Putative CorA-type Mg(2+) transporter; Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high. May also mediate uptake of Co(2+). (317 aa) |
| | yqhB | Putative membrane associated protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (442 aa) |
| | rsbRD | Component of the piezosome (stressosome); One of 4 functionally non-identical RsbR paralogs, it functions in the environmental signaling branch of the general stress response. (278 aa) |
| | mgsR | Transcriptional regulator of stress; Regulates transcription of a subregulon within the general stress response. Exerts positive and negative effects in response to ethanol stress. (126 aa) |
| | yqgC | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (160 aa) |
| | recO | DNA double strand break repair and homologous recombination factor; Plays a role in DNA double-stranded break repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecR. Is recruited to repair centers, foci that are the site of double-strand break(s) after RecN and before RecF; may actively recruit RecF. (255 aa) |
| | phoH | Phosphate starvation-induced protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type ph: phenotype. (319 aa) |
| | yqbM | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8760915, 8969508; To B.subtilis XkdM. (147 aa) |
| | yrhK | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (96 aa) |
| | yrvD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (107 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (381 aa) |
| | queA | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | csbX | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. (435 aa) |
| | hemX | Negative effector of the concentration of glutamyl-tRNA reductase HemA; Required for HemL synthesis; To M.leprae U1620K. (276 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (455 aa) |
| | ysnF | Putative stress response protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. (273 aa) |
| | uvrC | Excinuclease ABC (subunit C); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (590 aa) |
| | trxA | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (104 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub- subfamily. (319 aa) |
| | ccpA | Transcriptional regulator (Lacl family); Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P- Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons. (334 aa) |
| | ytxJ | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8733232. (108 aa) |
| | ytxH | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16291680, 8733232; To C.plantagineum desiccation-related protein clone PCC3- 06. (151 aa) |
| | ytxG | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8733232. (140 aa) |
| | malS | NAD-dependent malic enzyme (conversion of malate into pyruvate); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (566 aa) |
| | opuD | Glycine betaine transporter; High-affinity uptake of glycine betaine. Does not mediate either carnitine or choline uptake; Belongs to the BCCT transporter (TC 2.A.15) family. (512 aa) |
| | rpmEB | Ribosomal protein L31; While neither of the L31 paralogs is essential, this protein does not seem to function as the main L31 protein. Has a higher affinity for 70S ribosomes than the zinc-containing L31 paralog; is able to displace it to varying extents, even under zinc-replete conditions. (82 aa) |
| | menC | O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (371 aa) |
| | ytaB | Putative receptor; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc: putative receptor. (155 aa) |
| | yuzH | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (84 aa) |
| | yugU | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0047 family. (132 aa) |
| | yvrE | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the SMP-30/CGR1 family. (292 aa) |
| | rsoA | Regulator of sigma-O; Together with RNA polymerase sigma factor SigO, positively regulates the expression of at least three operons, including oxdC- yvrL, sigO-rsoA and yvrJ. Required for the acid stress-dependent induction of the oxalate decarboxylase oxdC. (79 aa) |
| | yvgN | Glyoxal/methylglyoxal reductase; Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis; Belongs to the aldo/keto reductase family. (276 aa) |
| | yvgO | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 11988534. (161 aa) |
| | copB | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. (702 aa) |
| | csoR | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. (101 aa) |
| | yvaA | Putative oxidoreductase; Catalyzes the reversible NADPH-dependent reduction of scyllo- inosose (SIS) to scyllo-inositol (SI). Cannot use NADH instead of NADPH. May be involved in reduction of not only SIS but also various oxidized compounds manifested upon stressful conditions. (358 aa) |
| | yvaG | Putative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa) |
| | smpB | tmRNA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches t [...] (156 aa) |
| | yvaK | Carboxylesterase; Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones (By similarity). (246 aa) |
| | yvbG | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (211 aa) |
| | nagBA | N-acetylglucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (242 aa) |
| | uvrA | Excinuclease ABC (subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (957 aa) |
| | uvrB | Excinuclease ABC (subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociat [...] (661 aa) |
| | csbA | Putative membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (76 aa) |
| | hpf | Ribosome-associated sigma 54 modulation protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. May not be the only factor implicated. Might negatively regulate the activity of the sigma-54 factor (SigL). (189 aa) |
| | gtaB | UTP-glucose-1-phosphate uridylyltransferase; Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since UDP-glucose serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely d [...] (292 aa) |
| | yvyI | Putative phosphohexomutase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e: enzyme; Belongs to the mannose-6-phosphate isomerase type 1 family. (316 aa) |
| | ywtG | Putative carbohydrate transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (457 aa) |
| | ywsB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 15187182. (178 aa) |
| | ywsA | Hypothetical protein; Evidence 5: No homology to any previously reported sequences; PubMedId: 11782522. (98 aa) |
| | csbD | Conserved hypothetical protein; Evidence 7: Gene remnant. (62 aa) |
| | ywmF | Putative integral membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (159 aa) |
| | atpC | ATP synthase (subunit epsilon, F1 subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. (132 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity); Belongs to the SHMT family. (415 aa) |
| | ywlB | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (147 aa) |
| | rpoE | RNA polymerase (delta subunit); Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling. May function in sigma factor switching. It displaces RNA bound to RNA polymerase in a binary complex; Belongs to the RpoE family. (173 aa) |
| | ywjC | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (90 aa) |
| | ywiE | Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity). May have a role in the heat shock response since the level of the transcript of ywiE increases after a heat shock; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (500 aa) |
| | ywzA | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (81 aa) |
| | galT | Galactose-1-phosphate uridyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (513 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa) |
| | gspA | Putative glycosyl transferase (general stress protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (286 aa) |
| | yxzF | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (52 aa) |
| | katX | Major catalase in spores; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (547 aa) |
| | nnrA | NAD(P)H dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (276 aa) |
| | aldY | Putative aldehyde dehydrogenase; May contribute to protect cells against stress due to ethanol and related compounds; Belongs to the aldehyde dehydrogenase family. (485 aa) |
| | yxkA | Putative bacteriophage protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. (168 aa) |
| | yxjI | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the LOR family. (162 aa) |
| | katE | Catalase 2; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Involved in sporulation. (686 aa) |
| | yxxB | Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. (275 aa) |
| | csbC | Putative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (461 aa) |
| | yxnA | Putative oxidoreductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (356 aa) |
| | yxaB | Putative exopolysaccharide pyruvyl transferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (343 aa) |
| | yyzG | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (56 aa) |
| | yycD | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (66 aa) |
| | cdnD | Phosphodiesterase acting on cyclic dinucleotides; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. Overexpression leads to increased sensitivity to methyl methanesulfonate (MMS) and H(2)O(2). Overexpression leads to extreme sensitivity to the beta-lactam antibiotic cefuroxime (CEF), probably dependent on PDE activity. May monitor cellular heme or NO levels. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...] (659 aa) |
| | yyzH | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. (49 aa) |
| | yybO | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (435 aa) |
