(7 nodes) (2021) Cloning and expression of Staphylococcus simulans lysostaphin enzyme gene in Bacillus subtilis WB600. network (Bacillus subtilis 168)

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Your Input:
	aprE	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. (381 aa)
	mpr	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family. (313 aa)
	nprB	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family. (538 aa)
	nprE	Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family. (521 aa)
	bpr	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (1433 aa)
	sacB	Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (473 aa)
	epr	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family. (645 aa)

Your Current Organism:

Bacillus subtilis 168

NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aprE	bpr	BSU10300	BSU15300	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	0.518
aprE	mpr	BSU10300	BSU02240	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	0.920
aprE	nprB	BSU10300	BSU11100	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.	0.940
aprE	nprE	BSU10300	BSU14700	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family.	0.986
aprE	sacB	BSU10300	BSU34450	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	0.754
bpr	aprE	BSU15300	BSU10300	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	0.518
bpr	epr	BSU15300	BSU38400	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	0.529
bpr	mpr	BSU15300	BSU02240	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	0.973
bpr	nprB	BSU15300	BSU11100	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.	0.943
bpr	nprE	BSU15300	BSU14700	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family.	0.935
epr	bpr	BSU38400	BSU15300	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	0.529
epr	mpr	BSU38400	BSU02240	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	0.914
epr	nprB	BSU38400	BSU11100	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.	0.926
epr	nprE	BSU38400	BSU14700	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family.	0.878
mpr	aprE	BSU02240	BSU10300	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	0.920
mpr	bpr	BSU02240	BSU15300	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.	0.973
mpr	epr	BSU02240	BSU38400	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	Extracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family.	0.914
mpr	nprB	BSU02240	BSU11100	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.	0.942
mpr	nprE	BSU02240	BSU14700	Extracellular glutamyl-endopeptidase; Evidence 1c: Function experimentally demonstrated in the studied genus; Product type e: enzyme; Belongs to the peptidase S1B family.	Extracellular neutral metalloprotease; Extracellular zinc metalloprotease; Belongs to the peptidase M4 family.	0.929
nprB	aprE	BSU11100	BSU10300	Extracellular neutral protease B; Protease able to cleave casein in vitro. Belongs to the peptidase M4 family.	Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family.	0.940

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