STRINGSTRING
sipW sipW tapA tapA yrpC yrpC accD accD perR perR comP comP comX comX yuxH yuxH araE araE araR araR epsA epsA murC murC lcfB lcfB fabF fabF fabI fabI fabD fabD fabG fabG codY codY pps pps bkdAB bkdAB bkdAA bkdAA lipM lipM sinI sinI phrC phrC ycxA ycxA srfAD srfAD srfAC srfAC srfAB srfAB srfAA srfAA rpsE rpsE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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sipWType I signal peptidase; Required for the cleavage of the signal sequence of TasA and TapA, which are involved in biofilm formation. Belongs to the peptidase S26B family. (190 aa)
tapALipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. (253 aa)
yrpCGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa)
accDacetyl-CoA carboxylase (carboxyltransferase beta subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (290 aa)
perRTranscriptional regulator (Fur family); Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA; Belongs to the Fur family. (145 aa)
comPTwo-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation. (769 aa)
comXCompetence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified); Part of a major quorum-sensing system that regulates the development of genetic competence. Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA, that regulates directly the transcription of over 20 genes. Transport through the membrane may involve Spo0K. Under certain conditions plays a role in sporulation. (55 aa)
yuxHPutative phosphodiesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (409 aa)
araEArabinose-related compounds permease; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). (464 aa)
araRTranscriptional repressor of the ara regulon (LacI family); Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene, and to one sequence in the araR promoter. (362 aa)
epsAModulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. (234 aa)
murCUDP-N-acetyl muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (432 aa)
lcfBLong-chain fatty-acid-CoA ligase (degradative); Involved in the degradation of long-chain fatty acids; Belongs to the ATP-dependent AMP-binding enzyme family. (513 aa)
fabFBeta-ketoacyl-acyl carrier protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (413 aa)
fabIEnoyl-acyl carrier protein reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism. (258 aa)
fabDMalonyl CoA:acyl carrier protein transacylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the FabD family. (317 aa)
fabGBeta-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
codYTranscriptional regulator, GTP and BCAA-dependent; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP- binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor. (259 aa)
ppsPutative PEP-dependent enzyme; Might catalyze the phosphorylation of pyruvate to phosphoenolpyruvate. (866 aa)
bkdABBranched-chain alpha-keto acid dehydrogenase E1 subunit; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (327 aa)
bkdAABranched-chain alpha-keto acid dehydrogenase E1 subunit; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3); Belongs to the BCKDHA family. (330 aa)
lipMProtein octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. Is also able to catalyze the reverse reaction. Octanoyl-CoA can also act as a substrate although very poorly. Does not display lipoate protein ligase activity, despite its sequence similarity to LplA; Belongs to the octanoyltransferase LipM family. (278 aa)
sinIAntagonist of SinR; Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE. (57 aa)
phrCPhosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. (40 aa)
ycxAPutative carboxylate permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. (408 aa)
srfADSurfactin synthetase; Probable thioesterase involved in the biosynthesis of surfactin; Belongs to the thioesterase family. (242 aa)
srfACSurfactin synthetase; Probably activates a leucine. (1275 aa)
srfABSurfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. (3583 aa)
srfAASurfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. (3587 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations); Belongs to the universal ribosomal protein uS5 family. (166 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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